Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
carbapenemase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaOXA-48-like | Reslit | 62 | carbapenems, meropenem +9 | Klebsiella pneumoniae +37 | Arabian Peninsula|Saudi Arabia|Kuwait|Oman|United Arab Emirates, Middle East|Afghanistan|Iraq|Egypt|Pakistan|Lebanon|Iran|Jordan|Persian Gulf Countries|United Arab Emirates|Kuwait|Qatar|Bahrain|Oman|Saudi Arabia|Turkey, Norway, Korea, Germany, Toronto|Canada, Lebanon, Philippines, Spain, Ecuador, Europe|EU|non-EU|non-Member State|China|Spain|USA|Finland|Germany|Norway|Switzerland|Netherlands, France, India, Europe, Egypt, Eastern Cape Province, Republic of South Africa|South Africa, Guangzhou, China, Europe|Israel, Taiwan, Eastern Europe|Western Europe, Thailand, United States, China, Europe|United States|Latin America|Asia-Pacific, Ghana, Mexico, Chonburi, Thailand|Thailand, Houston, Texas|United States, Singapore, Iran, Iraq, Peru, Western Province of Sri Lanka, Northern Pacific Ocean|Norway Sea|Europe, Ivory Coast|Ghana, New York City, Europe|Italy|Brazil|Czechia|Germany|Finland|Netherlands|Norway|Sweden, Kenya, Argentina, Europe|North America|Asia|Southern Europe|Western Asia, England, India|United States, Malaysia, UK|Ireland | 2015, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | PRJNA295003 | - |
| blaoxa-48-like | Reslit | 1 | carbapenems | Escherichia coli | Thailand | 2022 | - | - |
Characterization of Carbapenem-Resistant Enterobacteriaceae with High Rate of Autochthonous Transmission in the Arabian Peninsula.
The study identified bla NDM, bla OXA-48-like, and bla VIM as the primary carbapenemase genes in carbapenem-resistant Enterobacteriaceae in the Arabian Peninsula, highlighting the significance of autochthonous transmission.
Dissemination of carbapenemases producing Gram negative bacteria in the Middle East.
The study reviews the dissemination of carbapenemase-producing Gram-negative bacteria in the Middle East, highlighting the prevalence of KPC, VIM, IMP, NDM, and OXA-48 enzymes in various bacterial species such as Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa.
Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014.
The study identified various carbapenemase genes including bla KPC, bla NDM, bla OXA-48-like, bla VIM, bla IMI, and bla IMP in different Enterobacteriaceae species. These genes conferred resistance to carbapenems. Additionally, mutations in pmrA and pmrB were associated with colistin resistance in Klebsiella pneumoniae.
NDM-5 and OXA-48 Co-producing Uropathogenic Escherichia coli Isolate: First Case in Korea.
The study reports the first case of a uropathogenic Escherichia coli isolate producing both NDM-5 and OXA-48 carbapenemases in Korea.
Rapid detection of carbapenemases directly from positive blood cultures by the β-CARBA test.
The study presents a new method for the rapid detection of carbapenemases directly from positive blood cultures using the β-CARBA test, achieving 100% sensitivity and 94.3% specificity for various carbapenemase types including OXA-48-like, NDM, KPC, VIM, and GIM.
Rapid detection of resistance to carbapenems and cephalosporins in Enterobacteriaceae using liquid chromatography tandem mass spectrometry.
The study developed a rapid resistance testing (RRT) protocol using liquid chromatography tandem mass spectrometry (LC-MS/MS) to detect hydrolysis of beta-lactam antibiotics, particularly imipenem, in carbapenemase-producing Enterobacteriaceae (CPE). The RRT method showed high sensitivity and specificity for CPE detection, with 100% accuracy for imipenem hydrolysis cutoffs between 50% and 80%.
Molecular Characterization of Carbapenem Resistant Klebsiella pneumoniae and Klebsiella quasipneumoniae Isolated from Lebanon.
The study identified several carbapenemase genes, including bla OXA-48, bla NDM-1, bla NDM-7, and bla CTX-M-15, as well as the chromosomally-encoded beta-lactamase bla OKP-B-3, in carbapenem-resistant Klebsiella pneumoniae and Klebsiella quasipneumoniae isolates from Lebanon.
Environmental Presence and Genetic Characteristics of Carbapenemase-Producing Enterobacteriaceae from Hospital Sewage and River Water in the Philippines.
The study identified NDM, KPC, OXA-48-like, GES, and IMI carbapenemase genes in carbapenemase-producing Enterobacteriaceae (CPE) isolated from hospital sewage and river water in the Philippines. NDM was the most prevalent gene type, followed by KPC, OXA-48-like, GES, and IMI. Additionally, CTX-M-type ESBL and 16S rRNA methylase genes were also detected.
Rapid Detection of KPC-Producing Enterobacterales Susceptible to Imipenem/Relebactam by Using the MALDI-TOF MS MBT STAR-Carba IVD Assay.
The study presents a MALDI-TOF MS-based method for rapidly detecting KPC-producing Enterobacterales susceptible to imipenem/relebactam, showing high sensitivity and specificity.
OXA-48 Carbapenemase in Klebsiella pneumoniae Sequence Type 307 in Ecuador.
The study reports the first case of Klebsiella pneumoniae ST307 harboring the blaOXA-48-like gene in Ecuador, highlighting the potential for international spread of carbapenem-resistant strains.
The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2017.
The report highlights high levels of antimicrobial resistance in zoonotic bacteria such as Salmonella and Campylobacter, as well as in indicator bacteria like Escherichia coli. Key findings include resistance to multiple antibiotics, including extended-spectrum beta-lactamases (ESBLs), AmpC beta-lactamases, and carbapenemases. Colistin resistance was observed at low levels, and multidrug-resistant strains were prevalent in certain serovars.
Rapid Detection and Characterization of Carbapenemases in Enterobacterales with a New Modified Carbapenem Inactivation Method, mCIMplus.
The study evaluates the mCIMplus test for rapid detection and characterization of carbapenemases in Enterobacterales, demonstrating high sensitivity and specificity for various carbapenemase types including OXA-48-like, NDM, KPC, VIM, GES-5, and IMP-1.
Emergence of plasmid-borne bla (oxa-181) gene in Ochrobactrum intermedium: first report from India.
The study reports the first detection of the plasmid-borne bla OXA-181 gene in Ochrobactrum intermedium, highlighting its role in carbapenem resistance.
Evaluation of the FilmArray(®) Pneumonia Plus Panel for Rapid Diagnosis of Hospital-Acquired Pneumonia in Intensive Care Unit Patients.
The FilmArray Pneumonia Plus Panel detected resistance genes including mecA/C, MREJ, blaCTX-M, blaNDM, and blaOXA-48-like in clinical samples, demonstrating its utility in rapid detection of antibiotic resistance in hospital-acquired pneumonia.
Phenotypic and Genotypic Features of Klebsiella pneumoniae Harboring Carbapenemases in Egypt: OXA-48-Like Carbapenemases as an Investigated Model.
The study identified bla OXA-48-like genes as a significant contributor to carbapenem resistance in Klebsiella pneumoniae isolates from Egypt, highlighting their prevalence and coexistence with other carbapenemase genes.
Occurrence, identification, and antibiogram signatures of selected Enterobacteriaceae from Tsomo and Tyhume rivers in the Eastern Cape Province, Republic of South Africa.
The study identified various beta-lactamase genes (bla TEM, bla CTX-M, bla SHV, bla OXA-1-like, bla PER, bla VIM, bla IMP, bla KPC, bla GES, bla OXA-48-like), plasmid-mediated AmpC beta-lactamase genes (bla EBC, bla ACC, bla FOX, bla CIT), tetracycline resistance genes (tetA, tetB, tetD, tetM), chloramphenicol resistance gene (catII), and sulfonamide resistance gene (sulII) in Enterobacteriaceae isolates from Tsomo and Tyhume rivers.
Clinical and microbiological characteristics of nosocomial, healthcare-associated, and community-acquired Klebsiella pneumoniae infections in Guangzhou, China.
The study identified bla KPC, bla NDM, and bla OXA-48-like as carbapenemase genes, and bla SHV, bla TEM, bla CTX-M-9-group, and bla CTX-M-1-group as ESBL genes in Klebsiella pneumoniae isolates. CRKP and ESBL-producing strains were predominantly found in healthcare-associated and nosocomial infections.
Multinational evaluation of the BioFire® FilmArray® Pneumonia plus Panel as compared to standard of care testing.
The BioFire® FilmArray® Pneumonia plus Panel outperformed standard of care testing in detecting pathogens and antibiotic resistance markers, including bla CTX-M, bla KPC, bla VIM, bla OXA-48-like, and bla IMP genes.
In vitro activity of imipenem/relebactam, meropenem/vaborbactam, ceftazidime/avibactam, cefepime/zidebactam and other novel antibiotics against imipenem-non-susceptible Gram-negative bacilli from Taiwan.
The study evaluated the in vitro activity of several novel antibiotics against imipenem-non-susceptible Gram-negative bacilli, highlighting the effectiveness of β-lactam/BLI-BLE combinations against isolates with various carbapenemase genes.
Usefulness of BioFire FilmArray BCID2 for Blood Culture Processing in Clinical Practice.
The BCID2 assay effectively detects resistance genes such as bla CTX-M, bla OXA-48-like, and bla VIM in blood culture specimens, aiding in the rapid identification of resistant pathogens.
Activity of meropenem/vaborbactam and comparators against Gram-negative isolates from Eastern and Western European patients hospitalized with pneumonia including ventilator-associated pneumonia (2014-19).
The study characterizes various carbapenemase genes, including bla KPC-3, bla KPC-2, bla KPC-12, bla VIM-like, bla NDM-1, and bla OXA-48-like, which confer resistance to carbapenems in Enterobacterales and Pseudomonas aeruginosa isolates from European hospitals.
Multiplex lateral flow immunochromatographic assay is an effective method to detect carbapenemases without risk of OXA-48-like cross reactivity.
The study evaluates the NG-Test® CARBA 5 assay for detecting carbapenemases in Enterobacterales, showing high sensitivity and specificity. It identifies bla KPC, bla OXA-48-like, bla NDM, bla VIM, bla IMP, bla IMI, and bla SME as the main carbapenemase genes detected.
Antibiotic Resistance Genes Among Carbapenem-resistant Enterobacterales (CRE) Isolates of Prapokklao Hospital, Chanthaburi Province, Thailand.
The study identified a high prevalence of carbapenem-resistant Enterobacterales (CRE) carrying multiple carbapenemase genes, including bla NDM, bla IMP, and bla OXA-48-like. These genes confer resistance to carbapenems, and their coexistence in many isolates highlights the complexity of resistance mechanisms.
Detection and Characterization of Targeted Carbapenem-Resistant Health Care-Associated Threats: Findings from the Antibiotic Resistance Laboratory Network, 2017 to 2019.
The study identified the prevalence of targeted carbapenemase genes (bla KPC, bla NDM, bla OXA-48-like, bla VIM, and bla IMP) in carbapenem-resistant Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii. bla KPC was the most common gene detected in CRE isolates, while bla VIM was prevalent in CP-CRPA isolates. Regional variations in the frequency of these genes were observed.
Rapid Detection and Differentiation of KPC and MBL Carbapenemases among Enterobacterales Isolates by a Modified Combined-Disk Test.
The study developed a modified combined-disk test (mCDT) to rapidly detect and differentiate KPC and MBL carbapenemases among Enterobacterales isolates, demonstrating high sensitivity and specificity for identifying carbapenem-resistant strains.
In vitro activity of the orally bioavailable ceftibuten/VNRX-7145 (VNRX-5236 etzadroxil) combination against a challenge set of Enterobacterales pathogens carrying molecularly characterized beta-lactamase genes.
The study evaluated the in vitro activity of ceftibuten combined with VNRX-5236 against Enterobacterales pathogens carrying various beta-lactamase genes, including bla OXA-48, bla OXA-232, bla KPC-3, and bla KPC-2. VNRX-5236 significantly reduced the MIC of ceftibuten against these isolates, demonstrating effective restoration of ceftibuten activity against beta-lactamase-producing Enterobacterales.
Rapid Detection of bla(KPC), bla(NDM), bla(OXA-48-like) and bla(IMP) Carbapenemases in Enterobacterales Using Recombinase Polymerase Amplification Combined With Lateral Flow Strip.
The study developed a rapid RPA-LFS assay for detecting four major carbapenemase genes (blaKPC, blaNDM, blaOXA-48-like, and blaIMP) in Enterobacterales, demonstrating high specificity and sensitivity.
High Prevalence of Klebsiella pneumoniae in Greek Meat Products: Detection of Virulence and Antimicrobial Resistance Genes by Molecular Techniques.
The study found a high prevalence of Klebsiella pneumoniae in Greek meat products, with most isolates carrying carbapenemase resistance genes such as blaNDM-like and blaOXA-48-like, along with virulence genes like ecpA, fimH-1, and mrkA.
Environmental surveillance of ESBL and carbapenemase-producing gram-negative bacteria in a Ghanaian Tertiary Hospital.
The study identified various ESBL and carbapenemase genes, including bla NDM-1, bla OXA-48-like, bla CTX-M-15, bla SHV, bla OXA-1, and tet(X3), in environmental samples from a Ghanaian hospital, highlighting the presence of multidrug-resistant gram-negative bacteria.
Surveillance of Antimicrobial Resistance in Hospital Wastewater: Identification of Carbapenemase-Producing Klebsiella spp.
The study identified bla KPC and bla OXA-48-like genes in carbapenem-resistant Klebsiella spp. isolates from hospital wastewater, highlighting the presence of carbapenemase-producing bacteria in wastewater treatment plants.
Molecular characterization of multidrug-resistant ESKAPEE pathogens from clinical samples in Chonburi, Thailand (2017-2018).
The study identified multiple AMR genes in ESKAPEE pathogens, including bla OXA-23, bla NDM, bla OXA-48-like, bla CTX-M group 1, bla CTX-M group 9, mcr-1, mcr-3, mecA, and vanA. These genes conferred resistance to various antibiotics such as carbapenems, beta-lactams, colistin, methicillin, and vancomycin.
Systematic Analysis of Mobile Genetic Elements Mediating β-Lactamase Gene Amplification in Noncarbapenemase-Producing Carbapenem-Resistant Enterobacterales Bloodstream Infections.
The study identifies bla CTX-M-15, bla OXA-1, bla CTX-M-1, bla TEM-1, and bla CMY as key β-lactamase genes contributing to carbapenem resistance in noncarbapenemase-producing Enterobacterales (non-CP-CRE) bloodstream infections, with gene amplification mediated by IS 26 and IS Ecp1 elements.
Genomic Surveillance of Carbapenem-Resistant Klebsiella pneumoniae from a Major Public Health Hospital in Singapore.
The study identified multiple carbapenemase genes, including blaKPC-2, blaOXA-48-like, and blaNDM, along with 16S rRNA methyltransferases (armA, rmtF, rmtB) and extended-spectrum beta-lactamase blaCTX-M-15, contributing to carbapenem and aminoglycoside resistance in Klebsiella pneumoniae isolates from Singapore.
Beta-lactamase determinants and molecular typing of carbapenem-resistant classic and hypervirulent Klebsiella pneumoniae clinical isolates from southwest of Iran.
The study identified several beta-lactamase genes, including bla NDM, bla IMP, bla VIM, bla GES, bla OXA-48-like, bla CTX-M, bla SHV, bla TEM, bla FOX, bla DHA, bla CMY, bla LAT, and bla ACT, which are responsible for carbapenem resistance in Klebsiella pneumoniae isolates from southwest Iran.
Occurrence of virulence factors and carbapenemase genes in Salmonella enterica serovar Enteritidis isolated from chicken meat and egg samples in Iraq.
The study identified carbapenemase genes blaIMP, blaOXA-48-like, and blaNDM, along with tetracycline resistance genes tetA and tetB, and trimethoprim-sulfamethoxazole resistance genes dfrA1 and sul1 in Salmonella enterica serovar Enteritidis isolates from chicken meat and eggs in Iraq.
Clinical Risk Factors and Microbiological and Intestinal Characteristics of Carbapenemase-Producing Enterobacteriaceae Colonization and Subsequent Infection.
The study identifies bla OXA-48-like, bla KPC-2, and bla NDM-1 as the primary carbapenemase genes associated with CRE colonization and subsequent infection, highlighting their role in carbapenem resistance.
The Distribution of Mobile Colistin-Resistant Genes, Carbapenemase-Encoding Genes, and Fluoroquinolone-Resistant Genes in Escherichia coli Isolated from Natural Water Sources in Upper Northeast Thailand.
The study identified various antimicrobial resistance genes in E. coli isolates from natural water sources in upper northeast Thailand, including mcr-1, mcr-8, mcr-9, bla oxa-48-like, aac(6')-bl-cr, qepA, and oqxAB, which confer resistance to polymyxin, carbapenem, aminoglycoside, and fluoroquinolone antibiotics.
First Isolates of OXA-48-Like Carbapenemase-Producing Enterobacteriaceae in A Specialized Cancer Center.
The study identifies the first isolates of OXA-48-like CPE in a cancer center, highlighting the importance of specific screening methods for detection.
Carbapenem-resistant hypermucoviscous Klebsiella pneumoniae clinical isolates from a tertiary hospital in China: Antimicrobial susceptibility, resistance phenotype, epidemiological characteristics, microbial virulence, and risk factors.
The study identified bla KPC-2, bla NDM, bla IMP, and bla OXA-48-like as the main carbapenemase genes in carbapenem-resistant K. pneumoniae (CRKP) isolates. These genes conferred resistance to carbapenems, cephalosporins, and fluoroquinolones. The study also highlighted the importance of CZA in treating CRKP infections.
Performance of Phenotypic Tests to Detect beta-lactamases in a Population of beta-lactamase Coproducing Enterobacteriaceae Isolates.
The study identified various beta-lactamase genes including CTX-M, CMY, DHA, ACT, NDM, and OXA-48-like in Enterobacteriaceae isolates. These genes were associated with resistance to multiple β-lactam antibiotics. The performance of phenotypic tests for detecting these resistance mechanisms was evaluated.
Antibiotic Resistance Profiles and ARG Detection from Isolated Bacteria in a Culture-Dependent Study at the Codfish Industry Level.
The study identified various antibiotic resistance genes in bacteria isolated from codfish products and environmental samples, highlighting the presence of tetracycline, clindamycin, and oxacillin resistance genes in Staphylococcus spp., as well as beta-lactam and carbapenem resistance genes in Gram-negative bacteria.
Screening for Resistant Bacteria, Antimicrobial Resistance Genes, Sexually Transmitted Infections and Schistosoma spp. in Tissue Samples from Predominantly Vaginally Delivered Placentae in Ivory Coast and Ghana.
The study identified multiple beta-lactamase genes, including bla CTX-M, bla IMP, bla GES, bla VIM, bla OXA-58-like, bla NDM, bla OXA-23-like, bla OXA-48-like, and bla KPC, in placental tissue samples from Ivory Coast and Ghana. These genes confer resistance to various beta-lactam antibiotics, indicating a high prevalence of antimicrobial resistance in the studied region.
Clinical, microbiological and genomic characterization of Gram-negative bacteria with dual carbapenemases as identified by rapid molecular testing.
The study characterizes dual carbapenemase-producing organisms (DCPOs) and identifies various carbapenemase genes including bla NDM, bla OXA-48-like, and bla KPC. These genes were found to confer resistance to carbapenems and were located on distinct plasmids, except for one case where both bla NDM and bla KPC were on a single plasmid.
A growing battlefield in the war against biofilm-induced antimicrobial resistance: insights from reviews on antibiotic resistance.
The review discusses various mechanisms of biofilm-induced antimicrobial resistance, including the role of efflux pumps such as AcrAB-TolC, MexAB-OprM, AdeFGH, and AcrD in conferring resistance to multiple classes of antibiotics.
Antimicrobial Resistance in Salmonella spp. from Food-Producing Animals and Human Cases in the EU
The study identifies several AMR genes, including bla CTX-M-1, bla CTX-M-14b, bla SHV-12, tet(X3), and tet(X4), in Salmonella isolates from food-producing animals and human cases in the EU. These genes confer resistance to various antibiotics, highlighting the spread of multidrug-resistant Salmonella strains.
In vitro activity of meropenem-vaborbactam plus aztreonam against metallo-β-lactamase-producing Klebsiella pneumoniae.
The study evaluates the in vitro activity of meropenem-vaborbactam plus aztreonam (MEV-ATM) against metallo-β-lactamase (MBL)-producing Klebsiella pneumoniae isolates, identifying OmpK36 134-135GD-insertion and increased copy numbers of bla NDM-1 and bla OXA-48-like as key factors in MEV-ATM non-susceptibility.
Emergence of carbapenem resistant gram-negative pathogens with high rate of colistin resistance in Egypt: A cross sectional study to assess resistance trends during the COVID-19 pandemic.
The study identified high prevalence of carbapenem resistance in Gram-negative pathogens in Egypt, with bla NDM and bla OXA-48-like being the most prevalent carbapenemase genes. Plasmid-mediated quinolone resistance genes qnrS and qnrB were also detected. Additionally, several aminoglycoside resistance genes and integron-associated gene cassettes were characterized.
Carbapenem-Resistant and Extended-Spectrum β-Lactamase-Producing Enterobacterales in Children, United States, 2016-2020.
The study identified bla NDM, bla OXA-48-like, and bla KPC genes as the primary carbapenemase producers in carbapenem-resistant Enterobacterales (CRE) cases among children in the United States from 2016 to 2020.
Molecular characterization of NDM and OXA-48-like-producing Klebsiella pneumoniae ST16 and hypervirulent ST337 clone among two patients; a case report.
The study identifies carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates carrying bla NDM, bla OXA-48-like, bla CTX-M, bla TEM, and bla SHV genes, along with virulence genes iucA, rmpA2, and rmpA in a hypervirulent ST337 clone. These isolates exhibited resistance to multiple antibiotics, including meropenem and colistin.
Plasmid-Mediated Spread of Carbapenem Resistance in Enterobacterales: A Three-Year Genome-Based Survey.
The study identified various carbapenemase genes, including KPC-2, KPC-3, OXA-48, NDM-1, NDM-5, VIM-1, OXA-23, and OXA-72, which contribute to carbapenem resistance in Enterobacterales. These genes were found in multiple species and were associated with plasmid-mediated resistance.
Biofilm Formation and Antibiotic Resistance Profiles in Carbapenemase-Producing Gram-Negative Rods-A Comparative Analysis between Screening and Pathological Isolates.
The study identified carbapenemase genes bla OXA-48-like, bla NDM, and bla VIM in clinical isolates of Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa. These genes were associated with carbapenem resistance but were not the main determinants of resistance in screening isolates.
Evaluation of an expanded antibiotic resistance gene panel on prediction of antimicrobial susceptibility results for Gram-negative bacteria in blood cultures.
The study evaluated the QIAstat-Dx BCID panel for detecting antibiotic resistance genes in Gram-negative bacteria from blood cultures. It found that the panel effectively identified several resistance genes, including bla CTX-M, bla KPC, bla NDM, and others, which are crucial for predicting antimicrobial susceptibility. The panel showed high sensitivity and specificity for identifying resistance genes and predicting susceptibility, especially for beta-lactam antibiotics.
Carbapenemase-producing bacteria recovered from Nairobi River, Kenya surface water and from nearby anthropogenic and zoonotic sources.
The study identified multiple carbapenemase-encoding genes, including bla NDM, bla KPC, bla VIM, bla OXA-48-like, bla IMP, and bla GES, in various bacterial species from Nairobi River and surrounding environments.
National Multicenter Study on the Prevalence of Carbapenemase-Producing Enterobacteriaceae in the Post-COVID-19 Era in Argentina: The RECAPT-AR Study.
The study identified bla NDM, bla KPC, and bla OXA-163 as the main carbapenemase genes in Enterobacterales isolates from Argentina, with NDM and KPC being the most prevalent.
Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone.
The study identifies the intricate interplay between CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multidrug-resistant Klebsiella pneumoniae clone, highlighting the prevalence of carbapenemase genes such as blaNDM, blaOXA-48-like, blaKPC, and extended-spectrum beta-lactamase CTX-M-15.
Assessment of the Diagnostic Accuracy of the Modified Hodge Test and Modified Carbapenem Inactivation Method for Identifying Carbapenem Resistance Mechanisms in Klebsiella pneumoniae: A Whole Genome Sequencing-Based Exploratory Study.
The study identified bla OXA-48-like, bla NDM-1, bla NDM-5, and bla KPC genes as the main carbapenem resistance mechanisms in Klebsiella pneumoniae isolates, with bla OXA-48-like being the most prevalent.
The importance of monitoring a new antibiotic: ceftazidime/avibactam usage and resistance experience from England, 2016 to 2020.
The study identified the presence of ceftazidime/avibactam resistance in Enterobacterales in England, with nearly 90% of resistance cases associated with metallo-beta-lactamase (MBL) genes such as bla KPC, bla OXA-48-like, bla NDM, bla VIM, and bla IMP. These genes were experimentally validated as conferring resistance to ceftazidime/avibactam.
Evaluation of the rapid lateral flow assay (LFA) for detection of five major carbapenemase enzyme families in genotypically characterised bacterial isolates.
The study evaluates a rapid lateral flow assay (LFA) for the detection of five major carbapenemase enzyme families (KPC, NDM, VIM, IMP, and OXA-48-like) in genotypically characterized bacterial isolates. The LFA showed high sensitivity and specificity for detecting these carbapenemases, with some limitations noted for NDM detection.
Molecular characterization of carbapenem-resistant Enterobacterales (CRE) and in vitro activity of novel beta lactams against CRE isolates from Malaysia.
The study identified bla NDM, bla OXA-48-like, and bla VIM as the主要 carbapenemase genes in CRE isolates from Malaysia. Cefiderocol showed the highest in vitro activity against CRE isolates, particularly those harboring bla NDM.
Antimicrobial resistance among agents of hospital-acquired lower respiratory tract infection in the UK and Ireland: trends from 2008/2009 to 2018/2019.
The study identifies bla OXA-23 and bla OXA-58 as key carbapenem resistance genes in Acinetobacter baumannii and related species, highlighting their role in multidrug resistance.
Polyphenols as Potential beta-lactamase Inhibitors: An Integrated Computational and Experimental Study.
This study identifies quercetin, kaempferol, caffeic acid, and 3,4-dihydroxybenzoic acid as potential beta-lactamase inhibitors, demonstrating their ability to inhibit beta-lactamase activity and enhance the efficacy of β-lactam antibiotics against carbapenem-resistant bacteria.
Prevalence and characterization of carbapenem-resistant gram-negative bacteria from poultry in Tamil Nadu, India.
The study identified bla NDM-1, bla KPC-3, and bla OXA-48-like carbapenemase genes in various carbapenem-resistant gram-negative bacteria isolated from chicken meat samples in Tamil Nadu, India. These genes were found to confer resistance to meropenem.
Cross-regional dynamics of antibiotic resistance (AR): Genomic evidence of transmission for Escherichia coli carrying last-resort AR gene between food animals and humans in China.
The study identifies the transmission of LARG-harboring E. coli between food animals and humans in China, highlighting the role of cross-regional transmission in the spread of antibiotic resistance.
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