Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaOXA-50-like | Reslit | 2 | ceftazidime avibactam, imipenem | Pseudomonas aeruginosa | Colombia|Chile|Argentina|Mexico|Brazil, China | 2023 | PRJNA729968 | - |
| blaOXA-50-Like | Reslit | 1 | ceftazidime, cefepime +3 | Pseudomonas aeruginosa | Guangdong, China | 2023 | - | - |
Molecular Mechanisms of Resistance to Ceftazidime/Avibactam in Clinical Isolates of Enterobacterales and Pseudomonas aeruginosa in Latin American Hospitals.
The study identifies multiple AMR genes and mutations contributing to CZA resistance in Enterobacterales and P. aeruginosa, including MBLs, blaKPC, blaVIM, blaIMP, blaNDM, blaSPM-1, and various mutations in genes related to efflux pumps, porins, and beta-lactamases.
Whole-genome sequencing reveals high-risk clones of Pseudomonas aeruginosa in Guangdong, China.
The study identified multiple AMR genes, including aac(6')-IIa, aac(6')-Ib4, aac(6')-Ib7, aac(6')-Ib9, aac(6')-Ib10, aac(3)-IId, aadA, aadA2, aadA3, aadA7, aadA13, bla OXA-50-Like, bla OXA-1-Like, bla OXA-10-Like, bla OXA-21-Like, bla VIM-2, bla IMP-9, bla IMP-45, bla KPC-2, bla CTX-M-13, bla CARB-1, bla CARB-3, qnrVC1, qnrVC6, bla PDC-3, and bla PDC-5, in Pseudomonas aeruginosa isolates from Guangdong, China, highlighting the high prevalence of multidrug-resistant and carbapenem-resistant strains.
Emergence of ST463 exoU-Positive, Imipenem-Nonsusceptible Pseudomonas aeruginosa Isolates in China.
The study identified bla PDC, bla OXA-50, bla OXA-50-like, bla KPC-2, and bla OXA-486 as key resistance genes in imipenem-nonsusceptible Pseudomonas aeruginosa isolates. Additionally, mutations in PBP3 (F533L) and disruptions in oprD were associated with resistance. The ST463 lineage was highlighted as a multidrug-resistant and hypervirulent strain.
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