blaoxa24/40

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ß-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to blaoxa24/40

AMR Rules

Browse AMR rules for blaoxa24/40

Validation StatusCandidate

Overview

Mechanism: hydrolysis of β-lactam antibiotics
Validation Method: plasmid analysis and PCR detection
Drug Classes: carbapenems
Organisms: Acinetobacter baumannii
Geographic Location: Spain
Papers: 2
Databases: Reslit

Papers2

Evolution of the Quorum network and the mobilome (plasmids and bacteriophages) in clinical strains of Acinetobacter baumannii during a decade.

PMID 29410443 · 2018

The study identified the presence of a plasmid harbouring blaOXA24/40 ß-lactamase and abKA/abkB genes in Acinetobacter baumannii strains, along with two temperate bacteriophages, Ab105-1ϕ and Ab105-2ϕ, which contain important viral defence proteins. Additionally, a new QQ enzyme, AidA, was characterised.

Gene Information

Gene Name: blaoxa24/40
Allele: blaOXA24/40
Encodes: ß-lactamase
Source Database: Reslit
Mechanism: hydrolysis of β-lactam antibiotics
Confers Resistance To: carbapenems
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Spain
Validation Method: plasmid analysis and PCR detection
Sequence Accession: KT588074|KT588075

Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System.

PMID 29463538 · 2018

The study identified the blaOXA24/40 beta-lactamase gene as a key factor in carbapenem resistance in Acinetobacter baumannii ST-2 clinical isolates, along with the AbkAB toxin-antitoxin system contributing to tolerance and persistence mechanisms under chlorhexidine and imipenem pressure.