blapdc−575

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beta-lactamase

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to blapdc−575

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Validation StatusCandidate

Overview

Mechanism: beta-lactamase
Validation Method: cloning and MIC testing
Drug Classes: ceftazidime avibactam
Organisms: Pseudomonas aeruginosa
Papers: 1
Databases: Reslit

Papers1

In vivo divergent evolution of cross-resistance to new β-lactam/β-lactamase inhibitor combinations in Pseudomonas aeruginosa following ceftazidime/avibactam treatment.

PMID 39514175 · 2025

The study identifies bla PDC−575, a novel beta-lactamase, and ampC overexpression as critical mechanisms for resistance to ceftazidime/avibactam and ceftolozane/tazobactam in Pseudomonas aeruginosa. Additionally, dacB mutation contributes to resistance.

Gene Information

Gene Name: blapdc−575
Allele: blaPDC−575
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: beta-lactamase
Confers Resistance To: ceftazidime avibactam
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: cloning and MIC testing
Sequence Accession: NG_231575|PRJNA826241

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blapdc−575

Gene Information

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blapdc−575

Gene Information