blar164s

View on PubMed

beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to blar164s

AMR Rules

Browse AMR rules for blar164s

Validation StatusCandidate

Overview

Mechanism: hydrolysis
Validation Method: mutagenesis + MIC testing
Drug Classes: cefotaxime
Organisms: Escherichia coli DH5α, Escherichia coli K-12
Papers: 1
Databases: Reslit

Papers1

Bacterial strain type and TEM-1 enzyme allele impact antibiotic susceptibility distribution in monoclonal populations: a single-cell droplet approach.

PMID 40740715 · 2025

The study characterizes the impact of TEM-1 beta-lactamase alleles (R164S and G238S) on antibiotic susceptibility in E. coli strains, demonstrating that increased catalytic activity correlates with higher resistance to cefotaxime.

Gene Information

Gene Name: blar164s
Allele: blaR164S
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: cefotaxime
Organisms Tested In: • Escherichia coli DH5α
• Escherichia coli K-12
Validation Method: mutagenesis + MIC testing

Comments (0)

No comments yet. Be the first to comment!

blar164s

Gene Information

Browse AMR Genes

blar164s

Gene Information