Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Beta-lactamase
Overview
The Complete Sequence and Comparative Analysis of a Multidrug-Resistance and Virulence Multireplicon IncFII Plasmid pEC302/04 from an Extraintestinal Pathogenic Escherichia coli EC302/04 Indicate Extensive Diversity of IncFII Plasmids.
The study characterizes the multidrug-resistant plasmid pEC302/04 from an extraintestinal pathogenic E. coli strain, identifying several AMR genes including blaTEM-1, aadA1, aadB, cmlA, and sul1, which confer resistance to various antibiotics.
Carriage of Extended-Spectrum Beta-Lactamase-Plasmids Does Not Reduce Fitness but Enhances Virulence in Some Strains of Pandemic E. coli Lineages.
The study found that ESBL-plasmid carriage does not reduce fitness but enhances virulence in some strains of pandemic E. coli lineages. It identified several AMR genes on the ESBL-plasmids, including beta-lactamases (blaCTX-M-15, blaCTX-M-27, blaCTX-M-14), tetracycline resistance genes (tetA, tetR), aminoglycoside resistance genes (aadA, aac(6')-Ib-cr), chloramphenicol resistance gene (catB4), sulfonamide resistance gene (sul2), streptomycin resistance genes (strA, strB), dihydrofolate reductase genes (dhfrVII, dfrA17), and aminoglycoside phosphotransferase gene (aph(3')-Ia). Non-antibiotic resistance genes such as finO, traT, icc, yfaX, yihA, and hha were also identified.
Genetic Diversity, Multidrug Resistance, and Virulence of Citrobacter freundii From Diarrheal Patients and Healthy Individuals.
The study identified several AMR genes in Citrobacter freundii isolates, including bla TEM−1, bla CTX−M−9, aac(6')-Ib-cr, qnrS1, and various qnrB alleles such as qnrB9, qnrB13, qnrB16, qnrB17, qnrB76, qnrB77, and a newly discovered qnrB92. These genes were associated with resistance to multiple antibiotics, including beta-lactams, aminoglycosides, and quinolones.
S. Enteritidis and S. Typhimurium Harboring SPI-1 and SPI-2 Are the Predominant Serotypes Associated With Human Salmonellosis in Saudi Arabia.
The study identified the presence of bla TEM−1, bla OXA−1, bla CTX−M−1 group, bla CTX−M−9 group, and bla OXA−48 genes in Salmonella isolates, which confer resistance to various antibiotics. Additionally, mutations in gyrA and parC genes were associated with ciprofloxacin resistance.
An Outbreak of Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae in an Intensive Care Unit of a Major Teaching Hospital in Wenzhou, China.
The study identified carbapenem-resistant and hypervirulent Klebsiella pneumoniae isolates carrying bla KPC−2, aac(3')-Ia, aac(6')-Ib, ANT(3')-Ia, rmtB, rmtC, qnrB, qnrS, oqxA, bla SHV−11, bla CTX−M−2 group, bla CTX−M−9 group, bla TEM−1, bla CMY−2, and bla DHA genes, contributing to multidrug resistance.
Prevalence and mechanisms of antibiotic resistance in Escherichia coli isolated from mastitic dairy cattle in Canada.
The study identified several AMR genes in E. coli isolates from bovine mastitis, including beta-lactamases (blaTEM-1, blaCARB-3, blaCMY-59), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aadA2), and multidrug efflux pump genes (acrA, acrB, acrD, tolC, baeR, emrA, emrB).
Genetic Configuration of Genomic Resistance Islands in Acinetobacter baumannii Clinical Isolates From Egypt.
The study identified a variety of AMR genes in Acinetobacter baumannii clinical isolates from Egypt, including novel variants such as blaADC-258 and resistance islands like RI-PER-7. Key findings include the prevalence of blaOXA-23, blaTEM-1, and armA, along with multiple resistance determinants associated with mobile genetic elements.
Serotype Diversity and Antimicrobial Resistance Profile of Salmonella enterica Isolates From Freshwater Turtles Sold for Human Consumption in Wet Markets in Hong Kong.
The study identifies the multidrug-resistance gene cfr for the first time in Salmonella, highlighting the expansion of the cfr reservoir and potential horizontal spread to other bacteria. It also detects various AMR genes such as floR, sul2, aph(3')-Ia, aph(3”)-Ib, aph(6)-Id, aac(6')-Ib-cr, bla CMY−2, bla TEM−1, qnrS1, erm(B), mph(E), msr(E), qepA8, arr-3, sul1, dfrA12, dfrA27, tet(A), tet(D), catB3, aadA16, aac(3)-IV, aph(4)-Ia, aadA2, and fosA7.
Genetic characterization of third- or fourth-generation cephalosporin-resistant avian pathogenic Escherichia coli isolated from broilers.
The study identified various beta-lactamase genes, including bla CTX-M-15, bla TEM-1, bla CTX-M-1, bla CTX-M-14, bla SHV-12, bla CTX-M-27, bla OXA-1, bla TEM-135, and bla CMY-2, in third- or fourth-generation cephalosporin-resistant avian pathogenic E. coli isolates from Korean broiler operations.
Pathogenomics analysis of high-risk clone ST147 multidrug-resistant Klebsiella pneumoniae isolated from a patient in Egypt.
The study identifies multiple AMR genes in the MDR-KP isolate WSF99, including various beta-lactamases, carbapenemase, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and others, highlighting the complex resistance profile of this high-risk clone.
Genomic and molecular characterization of a ceftazidime-avibactam resistant Klebsiella pneumoniae strain isolated from a Chinese tertiary hospital.
The study identifies a ceftazidime-avibactam resistant Klebsiella pneumoniae strain carrying the bla NDM−5 gene, which confers resistance to carbapenems and other beta-lactam antibiotics. The strain also possesses other resistance genes including bla CTX−M−65, bla SHV−103, and bla TEM−1, contributing to multidrug resistance.
High prevalence and emerging cephalosporin resistance of penicillinase-producing Neisseria gonorrhoeae in Meizhou, China (2022-2024).
The study identified bla TEM−1 and bla TEM−135 as the main beta-lactamase genes in penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates in Meizhou, China. bla TEM−135 was associated with reduced susceptibility to cephalosporins.
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