blatem−116

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beta-lactamase

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UniProt

Protein entries specific to blatem−116

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Validation StatusCandidate

Overview

Mechanism: inhibition of beta-lactam antibiotics by blocking their activity
Validation Method: repression of gene expression via CRISPRi leading to increased susceptibility
Drug Classes: ampicillin
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics.

PMID 39747289 · 2025

The study demonstrates that CRISPR interference (CRISPRi) can re-sensitize laboratory strains and clinical isolates to last-resort antibiotics by repressing the expression of specific antibiotic resistance genes (ARGs).

Gene Information

Gene Name: blatem−116
Allele: blaTEM−116
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: inhibition of beta-lactam antibiotics by blocking their activity
Confers Resistance To: ampicillin
Organisms Tested In: • Escherichia coli
Validation Method: repression of gene expression via CRISPRi leading to increased susceptibility

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blatem−116

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blatem−116

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