blatem−135

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beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to blatem−135

AMR Rules

Browse AMR rules for blatem−135

Validation StatusCandidate

Overview

Validation Method: PCR and sequencing
Drug Classes: ampicillin, cephalothin, penicillin, ceftriaxone
Organisms: Avian pathogenic Escherichia coli, Neisseria gonorrhoeae
Geographic Location: China, South Korea
Papers: 2
Databases: Reslit

Papers2

Genetic characterization of third- or fourth-generation cephalosporin-resistant avian pathogenic Escherichia coli isolated from broilers.

PMID 36504870 · 2022

The study identified various beta-lactamase genes, including bla CTX-M-15, bla TEM-1, bla CTX-M-1, bla CTX-M-14, bla SHV-12, bla CTX-M-27, bla OXA-1, bla TEM-135, and bla CMY-2, in third- or fourth-generation cephalosporin-resistant avian pathogenic E. coli isolates from Korean broiler operations.

Gene Information

Gene Name: blatem−135
Allele: blaTEM−135
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: ampicillincephalothin
Organisms Tested In: • Avian pathogenic Escherichia coli
Geographic Location: South Korea
Validation Method: PCR and sequencing

High prevalence and emerging cephalosporin resistance of penicillinase-producing Neisseria gonorrhoeae in Meizhou, China (2022-2024).

PMID 41239259 · 2025

The study identified bla TEM−1 and bla TEM−135 as the main beta-lactamase genes in penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates in Meizhou, China. bla TEM−135 was associated with reduced susceptibility to cephalosporins.