bpeA

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Subunit of the drug efflux transporter RND4

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to bpeA

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Validation StatusCandidate

Overview

Mechanism: Efflux pump
Validation Method: Microarray analysis and qRT-PCR
Drug Classes: aminoglycosides, fluoroquinolones
Organisms: Burkholderia cenocepacia
Geographic Location: Europe
Papers: 1
Databases: Reslit

Papers1

Genomic expression analysis reveals strategies of Burkholderia cenocepacia to adapt to cystic fibrosis patients' airways and antimicrobial therapy.

PMID 22216120 · 2011

The study identifies several efflux pump genes (mdtABC, bpeA, BCAM0201, BCAM2188, BCAM0791) that are up-regulated in the more antibiotic-resistant B. cenocepacia isolate IST4113, contributing to its increased resistance to various antimicrobial classes.

Gene Information

Gene Name: bpeA
Allele: bpeA
Encodes: Subunit of the drug efflux transporter RND4
Source Database: Reslit
Mechanism: Efflux pump
Confers Resistance To: aminoglycosidesfluoroquinolones
Organisms Tested In: • Burkholderia cenocepacia
Geographic Location: Europe
Validation Method: Microarray analysis and qRT-PCR
Sequence Accession: E-MTAB-809

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bpeA

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bpeA

Gene Information