Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
RND efflux pump permease component
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S132A | - | - | Escherichia coli | erythromycin|clindamycin | Reslit | Candidate |
| S133A | - | - | Escherichia coli | erythromycin|clindamycin | Reslit | Candidate |
| S134D | - | - | Escherichia coli | erythromycin|clindamycin | Reslit | Candidate |
| T176V | - | - | Escherichia coli | clindamycin | Reslit | Candidate |
| T176E | - | - | Escherichia coli | clindamycin | Reslit | Candidate |
| L137Q | - | - | Escherichia coli | erythromycin|clindamycin | Reslit | Candidate |
Genomic and RT-qPCR analysis of trimethoprim-sulfamethoxazole and meropenem resistance in Burkholderia pseudomallei clinical isolates.
The study identifies a mutation in the amrR gene, a regulator of the AmrAB-OprA efflux pump, which leads to meropenem resistance in Burkholderia pseudomallei. This mutation was experimentally validated through genomic analysis and RT-qPCR.
Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate-binding pocket.
The hydrophilic patch in the substrate-binding pocket of BpeB and BpeF influences their substrate specificity, with mutations in this region altering resistance profiles to various antibiotics.
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