bpsA

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polysaccharide

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to bpsA

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: resists antimicrobial peptides by functioning as a dual surface shield and decoy
Validation Method: genetic deletion and complementation studies, MIC testing, ELISA, flow cytometry
Drug Classes: polymyxin b
Organisms: Bordetella pertussis, Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Bps polysaccharide of Bordetella pertussis resists antimicrobial peptides by functioning as a dual surface shield and decoy and converts Escherichia coli into a respiratory pathogen.

PMID 35969621 · 2022

The bpsA-D locus in Bordetella pertussis encodes a polysaccharide (Bps) that confers resistance to antimicrobial peptides (AMPs) such as polymyxin B and LL-37. Bps acts as a dual surface shield and decoy, reducing AMP binding and enhancing bacterial survival. Expression of Bps in E. coli also conferred resistance to these AMPs.

Gene Information

Gene Name: bpsA
Allele: bpsA-D
Encodes: polysaccharide
Source Database: Reslit
Mechanism: resists antimicrobial peptides by functioning as a dual surface shield and decoy
Confers Resistance To: polymyxin b
Organisms Tested In: • Bordetella pertussis
• Escherichia coli
Validation Method: genetic deletion and complementation studies, MIC testing, ELISA, flow cytometry

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bpsA

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bpsA

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