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carD

protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to carD

Browse AMR rules for carD

Overview

Mechanism: weakens interaction with RNAP
Drug Classes: rifampicin
Organisms: Mycobacterium smegmatis, Mycobacterium tuberculosis
Papers: 1
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R25E	-	weakens interaction with RNAP	Mycobacterium smegmatis, Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
R47E	-	weakens interaction with RNAP	Mycobacterium smegmatis, Mycobacterium tuberculosis	rifampicin	Reslit	Candidate

Papers1

1

Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesis.

PMID 22904282 · 2012

Mutations in CarD that weaken its interaction with RNAP β1 increase sensitivity to rifampin.

Mutation Information

carD: p.R25E carD: p.R47E

Protein Change: R25E, R47E
Organisms: Mycobacterium smegmatis, Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: weakens interaction with RNAP
Validation Method: transient rifampin treatment
Source Database: Reslit