cat

chloramphenicol acetyltransferase (CAT)

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to cat

Browse AMR rules for cat

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Drug Classes: CHLORAMPHENICOL, phenicols
Organisms: Agrobacterium fabrum str. C58, Campylobacter coli, Escherichia coli K-12, Enterococcus faecalis, Limosilactobacillus reuteri, Photobacterium damselae subsp. piscicida, Staphylococcus intermedius, Streptococcus suis, Vibrio anguillarum, Shouchella clausii, Geobacillus kaustophilus, Staphylococcus aureus, E. coli, Riemerella anatipestifer, Escherichia coli
Alleles: 10
Papers: 5
Databases: Card DatabaseResFinder Database
Mutations: 4

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A138T	-	enhanced thermostability	Geobacillus kaustophilus, Staphylococcus aureus	phenicols	Reslit	Candidate
T172A	C516G	-	E. coli, Escherichia coli	phenicols	Reslit	Candidate
H193A	-	-	E. coli	phenicols	Reslit	Candidate
H79A	C235G	significantly reduces CAT activity and chloramphenicol resistance	Riemerella anatipestifer, Escherichia coli	phenicols	Reslit	Candidate

Allele Variants10

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Afab_ACT_CHL	Card Database	1	-	Agrobacterium fabrum str. C58	-	-	M58472.1	AAA22081.1
Ccol_ACT	Card Database	1	-	Campylobacter coli	-	-	M35190.1	AAA23018.1
Ecol_catII	Card Database	1	-	Escherichia coli K-12	-	-	X53796.1	CAA37805.1
Efae_ACT_CHL	Card Database	1	-	Enterococcus faecalis	-	-	X92945.2	CAA63498.2
Lreu_cat-TC	Card Database	1	-	Limosilactobacillus reuteri	-	-	U75299.1	AAB53259.1
pp_cat	Card Database	1	-	Photobacterium damselae subsp. piscicida	-	-	D16171.1	BAA03718.1
Sint_ACT_CHL	Card Database	1	-	Staphylococcus intermedius	-	-	M64281.1	AAA26615.1
Ssui_ACT_CHL	Card Database	1	-	Streptococcus suis	-	-	AB080798.1	BAC11901.1
Vang_ACT_CHL	Card Database	1	-	Vibrio anguillarum	-	-	S48276.1	AAB23649.1
Acla_ACT_CHL	Card DatabaseResFinder Database	2	CHLORAMPHENICOL	Shouchella clausii	-	2009	AY238971.1	AAQ63644.1

Papers5

1

Gene Information

Gene Name: cat
Allele: Afab_ACT_CHL
Encodes: chloramphenicol acetyltransferase (CAT)
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Agrobacterium fabrum str. C58
Sequence Accession: M58472.1
Protein Accession: AAA22081.1
Notes: ARO:3004451

2

Gene Information

Gene Name: cat
Allele: Ccol_ACT
Encodes: chloramphenicol acetyltransferase (CAT)
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Campylobacter coli
Sequence Accession: M35190.1
Protein Accession: AAA23018.1
Notes: ARO:3004454

3

Gene Information

Gene Name: cat
Allele: Ecol_catII
Encodes: chloramphenicol acetyltransferase (CAT)
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Escherichia coli K-12
Sequence Accession: X53796.1
Protein Accession: CAA37805.1
Notes: ARO:3004656

4

Gene Information

Gene Name: cat
Allele: Efae_ACT_CHL
Encodes: chloramphenicol acetyltransferase (CAT)
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: X92945.2
Protein Accession: CAA63498.2
Notes: ARO:3004458

5

Gene Information

Gene Name: cat
Allele: Lreu_cat-TC
Encodes: chloramphenicol acetyltransferase (CAT)
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Limosilactobacillus reuteri
Sequence Accession: U75299.1
Protein Accession: AAB53259.1
Notes: ARO:3002671

6

Gene Information

Gene Name: cat
Allele: pp_cat
Encodes: chloramphenicol acetyltransferase (CAT)
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Photobacterium damselae subsp. piscicida
Sequence Accession: D16171.1
Protein Accession: BAA03718.1
Notes: ARO:3002689

7

Gene Information

Gene Name: cat
Allele: Sint_ACT_CHL
Encodes: chloramphenicol acetyltransferase (CAT)
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Staphylococcus intermedius
Sequence Accession: M64281.1
Protein Accession: AAA26615.1
Notes: ARO:3004457

8

Gene Information

Gene Name: cat
Allele: Ssui_ACT_CHL
Encodes: chloramphenicol acetyltransferase (CAT)
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Streptococcus suis
Sequence Accession: AB080798.1
Protein Accession: BAC11901.1
Notes: ARO:3004455

9

Gene Information

Gene Name: cat
Allele: Vang_ACT_CHL
Encodes: chloramphenicol acetyltransferase (CAT)
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Vibrio anguillarum
Sequence Accession: S48276.1
Protein Accession: AAB23649.1
Notes: ARO:3004460

10

A chromosomal chloramphenicol acetyltransferase determinant from a probiotic strain of Bacillus clausii.

PMID 19459958 · 2009

Gene Information

Gene Name: cat
Allele: Acla_ACT_CHL
Encodes: chloramphenicol acetyltransferase (CAT)
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CHLORAMPHENICOL
Organisms Tested In: • Shouchella clausii
Sequence Accession: AY238971.1
Protein Accession: AAQ63644.1
Notes: ARO:3004452

11

A chromosomal chloramphenicol acetyltransferase determinant from a probiotic strain of Bacillus clausii.

PMID 19459958 · 2009

Gene Information

Gene Name: cat
Allele: Acla_ACT_CHL
Encodes: chloramphenicol acetyltransferase (CAT)
Source Database: ResFinder Database
Mechanism: antibiotic inactivation
Confers Resistance To: CHLORAMPHENICOL
Organisms Tested In: • Shouchella clausii
Sequence Accession: AY238971.1
Protein Accession: AAQ63644.1
Notes: ARO:3004452

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