Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
type A-1 chloramphenicol O-acetyltransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| catA1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 203 | CHLORAMPHENICOL, phenicols | Aeromonas hydrophila +72 | Australia, Germany, Europe|United States|Australia, India, Global, Taiwan|India|Morocco|Hong Kong, East Sea of Korea, Japan, Zambia, South West London, UK, Nepal, Netherlands, Europe|Italy, Europe|Portugal, Nepal|Japan, Norway, San Francisco|Seattle|Minnesota|Minneapolis|Sacramento|Dallas|Jackson, China, North Carolina, Cambodia, Pakistan|China, Ghana, global, Global|global, Bangladesh|Pakistan|Nepal, Africa|Ghana|Kenya|Tanzania, Denmark|France|Poland|Italy|Hungary|Germany|Estonia|United States, Tanzania|Thailand|human|swine, Egypt|Africa|Europe|Asia|Middle East|Indonesia|India|USA, Ecuador, Pakistan|Denmark, UK, Brazil, South Africa, United States, Greece, Korea, Italy|Far East countries, Lake Victoria, Tanzania, Belgium, H1 Hospital, Czech Republic, Shanghai, China, Europe, Eastern Cape, South Africa, Malawi, Bangladesh, Guadeloupe|French West Indies, Jakarta, Egypt, Sweden, Nigeria, Kenya, Europe|Spain|Hungary|Germany|France|Belgium|Poland|United Kingdom|Denmark, Romania|Spain, sub-Saharan Africa|Burkina Faso|Ghana|Guinea-Bissau|Kenya|Senegal, England, Iran, United Kingdom|England|Australia, Europe|broiler production pyramid, East Coast Peninsular Malaysia, Thailand, Spain, Africa|Gambia, North Carolina|USA, China|Bangladesh|USA|England|India, United Kingdom, southern Ontario, Canada, Sierra Leone, South Australia|Australia, New Zealand, Abuja, Nigeria, North Sea|Baltic Sea, South America|Chile, Italy, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Europe|Asia|North America|Western and South-Eastern Asia, Pakistan, Czech Republic|location A|location B|location C, Russia|Switzerland|Italy|USA|Norway|Spain|Ghana, Pakistan|Karachi, Pakistan, Alexandria, Egypt, Mozambique, Croatia, Salish Sea, Uganda, Lahore, Pakistan, Lebanon, Peruvian Amazon, Bangkok, Thailand, Zanzibar, Accra, Ghana|Ghana, Ethiopia, South Asia|India|Bangladesh|Pakistan|Kenya, United States|Pakistan|Bangladesh|Nigeria|Iraq|India, Portugal|various regions, Fujian Province, Southeast China|China, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, Armenia, Taiwan, Central Zone of Mexico|Mexico, Ibadan, Nigeria, Western Balkans|Hungary, Shandong Province|adjacent regions in China, Paraguay|Northern Spain, China|North America|Asia|Europe|Africa|Other, Northern Nigeria|Nigeria, southwestern Nigeria, East Africa|Tanzania|Uganda, Egypt|Northern Egyptian governorates of Kafr El-Sheikh and Dakahlia, United Arab Emirates | 1979, 1993, 2001, 2002, 2003, 2004, 2009, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AJ973195.1 | CAJ00344.1 |
| cat | ResFinder DatabaseReslit | 181 | phenicols, CHLORAMPHENICOL | Spirochaeta aurantia +128 | Europe|North America|Asia, Europe, France, Taiwan, China|Vietnam, Argentina, Germany|United Kingdom|Ireland|France|Malta|Abu Dhabi|Hong Kong|Australia|Trinidad & Tobago|United States|Italy|Spain|Portugal|Switzerland|Canada|Middle East|USA|Asia|UK, Asia|Africa|Europe|South America|Global, Ireland, Russia, Iraq, United States|U.S.|France|Korea, Denmark|USA|Australia|PNG, Uganda, Democratic Republic of the Congo, United States, Belgium, Brazil|China|Hong Kong|Indonesia|Israel|Nigeria|Peru|Singapore|Thailand|Vietnam, USA, Minnesota, Russia|Siberian Russia, Israel, Europe|Italy, China, Turkey, Kuwait, Thailand|Fiji|Kenya, Africa|Asia|Europe|South America|Oceania, pig|duck, Niger, Germany, Zambia|United States, Italy, Poland, Denmark|France|Germany|United Kingdom|Spain|The Netherlands|Norway|Sweden|Sudan|Egypt|Philippines|Vietnam|Japan|Australia|USA, Bangladesh, South-Kivu Province, Democratic Republic of Congo, Egypt, Jordan, East London|West London, wastewater treatment plants|Canada, Denmark, global, Portugal|Spain|The Netherlands, Spain, Estonia|swine, South Korea, University Hospital Tübingen, Rwanda, India|Malaysia|South China, Russia|permafrost, Quebec|Ontario|France|Switzerland, Poland|Ukraine, Detroit, Czech Republic, Korea, Saudi Arabia, Europe|North America|Netherlands|Denmark|Pennsylvania|United States|France, Cambodia, Europe|United States|Asia, Japan, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Ghana, Shanxi Province, Europe|Taiwan|USA, Malaysia, Peru, Mozambique|Manhiça, Mozambique, Swiss Canton Tessin|various herds|Switzerland, Moscow, Russia, Mexico, International Space Station, China|UK|Canada|Thailand|Netherlands|USA|Denmark|Spain|other nations, Switzerland, Israel|Germany|Kuwait|Syria, Switzerland|Europe, India, Shenzhen|Dapeng, Portugal, Europe|USA, Europe|Croatia, Mayurbhanj, Odisha, India|India, Southeast Nigeria|Nigeria, Asia|China, Netherlands, Bulgaria | 1970, 1976, 1977, 1982, 1985, 1986, 1991, 1993, 1995, 1999, 2000, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | U74080 | - |
| catA1/cat4 | Reslit | 1 | phenicols | Klebsiella pneumoniae | Kenya | 2017 | NCBI Accession no. KX377894|KX377894 | - |
| catA1-like | Reslit | 1 | phenicols | Klebsiella pneumoniae +1 | West Africa|Conakry, Guinea | 2018 | PRJNA421654|PJMH00000000|PJMI00000000|PJMJ00000000|PJMK00000000|PJML00000000|PJMM00000000 | - |
| cat A1 | Reslit | 8 | phenicols | Klebsiella pneumoniae +7 | Cameroon, South Africa, India, Southeast Nigeria, Italy, Germany, Shenzhen, China, Egypt|Northern Egyptian governorates of Kafr El-Sheikh and Dakahlia | 2018, 2019, 2022, 2023, 2024, 2025 | PDVM00000000|PDVF00000000|PDVG00000000|PDVC00000000|PDVE00000000|PDVU00000000|PDVD00000000 | - |
Spirochaeta aurantia has diacetyl chloramphenicol esterase activity.
Spirochaeta aurantia possesses a cell-associated diacetyl chloramphenicol esterase that converts diacetyl chloramphenicol to chloramphenicol, reducing its effectiveness as an antibiotic.
Ferric dicitrate transport system (Fec) of Shigella flexneri 2a YSH6000 is encoded on a novel pathogenicity island carrying multiple antibiotic resistance genes.
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
A multiresistant clone of Shiga toxin-producing Escherichia coli O118:[H16] is spread in cattle and humans over different European countries.
In34, a complex In5 family class 1 integron containing orf513 and dfrA10.
The study identifies and characterizes the class 1 integron In34, which contains multiple antibiotic resistance genes including aadB, dfrA10, aphA1, catA1, blaTEM, and sul1. These genes confer resistance to various antibiotics such as gentamicin, kanamycin, tobramycin, trimethoprim, chloramphenicol, ampicillin, and sulfamethoxazole.
The complete nucleotide sequence of the resistance plasmid R478: defining the backbone components of incompatibility group H conjugative plasmids through comparative genomics.
Selection and characterization of a promoter for expression of single-copy recombinant genes in Gram-positive bacteria.
The study identifies and characterizes a strong chromosomal promoter (PP) from Streptococcus gordonii that enables stable expression of single-copy recombinant genes in various Gram-positive bacteria.
Cats as a risk for transmission of antimicrobial drug-resistant Salmonella.
The study identified several antimicrobial resistance genes in Salmonella isolates from cats, including blaTEM, cat, sul2, tet(A), and dfrA1, which confer resistance to ampicillin, chloramphenicol, sulfonamides, tetracycline, and trimethoprim, respectively.
Recognition of individual genes in diverse microorganisms by cycling primed in situ amplification.
The study describes the development of CPRINS-FISH for detecting specific genes in bacterial cells, including the ampicillin resistance gene (ampR), chloramphenicol acetyltransferase gene (cat), and the rpoD gene. These genes were successfully detected in various bacterial species, demonstrating the effectiveness of the method for identifying individual genes in complex microbial communities.
Comparative genomics of multidrug resistance in Acinetobacter baumannii.
The study identifies numerous resistance genes in the multidrug-resistant Acinetobacter baumannii strain AYE, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others, highlighting the complexity of its resistance mechanisms.
Use of the lambda Red recombinase system to produce recombinant prophages carrying antibiotic resistance genes.
The study demonstrates the successful incorporation of the cat and tet genes into the stx2 gene of prophages using the lambda Red recombinase system, resulting in the production of recombinant prophages that confer resistance to chloramphenicol and tetracycline.
Cloning and sequence analysis of a plasmid-encoded chloramphenicol acetyltransferase gene from Staphylococcus intermedius.
The chloramphenicol acetyltransferase gene (cat) from a 3.9 kb chloramphenicol resistance plasmid of Staphylococcus intermedius was cloned and analyzed, showing similarities to cat genes from other Staphylococcus species.
Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
The study identified a multidrug-resistant PVL+ CA-MRSA ST59 strain in Taiwan with a novel SCC mec type VII, carrying resistance genes such as tetK, cat, aadE, aph(3')-IIIa, ermB, blaZ, and cadDX.
The complete genome sequence and analysis of the epsilonproteobacterium Arcobacter butzleri.
Arcobacter butzleri strain RM4018 exhibits resistance to multiple antibiotics, including chloramphenicol, beta-lactams, macrolides, sulfonamides, quinolones, and 5-fluorouracil. Resistance to chloramphenicol is likely due to the presence of a cat gene encoding a chloramphenicol O-acetyltransferase. Beta-lactam resistance is possibly due to the presence of three putative beta-lactamases and the lrgAB operon. The absence of the upp gene contributes to high 5-fluorouracil resistance.
Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis.
The study identifies various genes in Streptococcus suis strains that are associated with virulence and potential drug resistance, highlighting the genomic diversity and evolution of this pathogen.
Antimicrobial resistances do not affect colonization parameters of intestinal E. coli in a small piglet group.
The study identified various AMR genes in commensal E. coli from pigs, including blaTEM, catA1, aph(3')-Ia, aadA, strA/strB, tet(A), tet(B), sul1, sul2, and sul3. These genes conferred resistance to antibiotics such as ampicillin, chloramphenicol, kanamycin, neomycin, streptomycin, spectinomycin, tetracycline, and sulfamethoxazole. However, the presence of these resistance genes did not provide a significant colonization advantage or disadvantage in the pig intestine.
Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042.
The study identifies several antibiotic resistance genes in the enteroaggregative E. coli strain 042, including cat, tetA, aadA1, suI, and emrE, which contribute to resistance against chloramphenicol, tetracycline, streptomycin, spectinomycin, sulfonamide, and ethidium bromide.
Genomic analysis of Acinetobacter baumannii A118 by comparison of optical maps: identification of structures related to its susceptibility phenotype.
The study identifies the absence of the AbaR-type resistance island and the tet(A) gene in Acinetobacter baumannii A118, which may explain its susceptibility to various antibiotics. It also characterizes genes such as cat, bla_ADC, bla_OXA-51-like, carO, and pbp2, which are involved in resistance to chloramphenicol, cephalosporins, carbapenems, and other antibiotics.
A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus.
The study characterizes various methicillin-resistant Staphylococcus aureus (MRSA) clones, highlighting their antimicrobial resistance and virulence-associated markers, with a focus on SCC mec types and PVL status.
Diversity and evolution of AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I.
The study characterizes various AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I, identifying multiple AMR genes such as blaTEM-1, aacC1, aadA1, aacA4, dfrA1, catA1, sul1, and tetA, which confer resistance to beta-lactams, aminoglycosides, chloramphenicol, sulfonamides, and tetracyclines.
Emergence of a globally dominant IncHI1 plasmid type associated with multiple drug resistant typhoid.
The study identifies the emergence of a globally dominant IncHI1 plasmid type (PST6) associated with multiple drug-resistant typhoid. Key resistance genes include blaTEM-1, cat, dfrA7, sul1, sul2, strAB, tetA, tetD, and betU, which contribute to resistance against ampicillin, chloramphenicol, trimethoprim, sulfamethoxazole, streptomycin, tetracycline, and high salt environments.
Characterization of multidrug-resistant Escherichia coli isolates from animals presenting at a university veterinary hospital.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from animals, including bla TEM, bla CTX-M-2, bla CMY-2, strA-strB, aadA, aphA1, aadB, cat, floR, sul1, sul2, tet(A), and tet(B). These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, chloramphenicol, sulfonamides, and tetracyclines.
QRDR mutations, efflux system & antimicrobial resistance genes in enterotoxigenic Escherichia coli isolated from an outbreak of diarrhoea in Ahmedabad, India.
The study identified QRDR mutations in gyrA and parC, as well as the aac(6')-Ib-cr gene, class 1 and class 2 integrons, and various resistance genes including blaTEM-1, catA1, dfrA1, dfrA17, aadA1, aadA5, strA, tet, and aphA1-Ia in ETEC strains, contributing to multidrug resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Comparative genomics and drug resistance of a geographic variant of ST239 methicillin-resistant Staphylococcus aureus emerged in Russia.
The study characterizes a Russian variant of ST239 methicillin-resistant Staphylococcus aureus (MRSA) with unique genomic features and drug resistance mechanisms, including mutations in rpoB, grlA, and gyrA genes leading to resistance against rifampicin and levofloxacin, as well as the presence of the tetM gene for tetracycline resistance and the ccrC1 gene for chloramphenicol and rifampicin resistance.
Complete genome sequence of Enterococcus faecium strain TX16 and comparative genomic analysis of Enterococcus faecium genomes.
The study identified the pbp5-R allele, which confers ampicillin resistance in Enterococcus faecium strain TX16. This resistance determinant was found in most HA-clade isolates but not in CA-clade isolates.
Characteristics of plasmids in multi-drug-resistant Enterobacteriaceae isolated during prospective surveillance of a newly opened hospital in Iraq.
The study identified various plasmid-borne antimicrobial resistance genes in multi-drug-resistant Enterobacteriaceae isolates from a newly opened hospital in Iraq, including aminoglycoside, beta-lactam, sulfamethoxazole/trime-thoprim, tetracycline, and chloramphenicol resistance genes.
DNA microarray profiling of a diverse collection of nosocomial methicillin-resistant staphylococcus aureus isolates assigns the majority to the correct sequence type and staphylococcal cassette chromosome mec (SCCmec) type and results in the subsequent identification and characterization of novel SCCmec-SCCM1 composite islands.
The study identifies and characterizes novel SCCmec-SCCM1 composite islands in MRSA isolates, highlighting the presence of various AMR genes such as blaZ, erm(A), aadD, qacA, qacC, merA, merB, fosB, sdrM, aacA-aphD, far1 (fusB), Q6GD50 (fusC), and cat-pC194 (pMC524).
Development and Evaluation of a Microarray-Based Serogenotyping Assay for Salmonella
The study presents a microarray-based serogenotyping assay for Salmonella, demonstrating high correlation between genotypic and phenotypic characteristics. Several AMR genes were identified and validated, showing strong association with AMR phenotypes.
Copy Number Change of the NDM-1 sequence in a multidrug-resistant Klebsiella pneumoniae clinical isolate.
The study identifies the blaNDM-1 gene on plasmid pKPX-1 as a key factor in carbapenem resistance in a multidrug-resistant Klebsiella pneumoniae isolate. It also characterizes additional resistance genes such as aac(6')-Ib, aac(6')-Ib-cr, aph(3')-I, strB, qnrB, tetA, catA1, and catB4, which contribute to resistance against aminoglycosides, fluoroquinolones, tetracycline, and chloramphenicol.
Genetic mechanisms of antimicrobial resistance identified in Salmonella enterica, Escherichia coli, and Enteroccocus spp. isolated from U.S. food animals.
The study identifies various AMR genes in Salmonella enterica, Escherichia coli, and Enterococcus spp. isolated from U.S. food animals, including aac(3'), aac(6'), aadA, aadA1, aadA2, aadA12, aphAI, aph(3')-Ii-iv, strA, strB, bla CMY-2, bla TEM-1, bla PSE-1, floR, cmlA, cat1, cat2, sul1, sul2, dfr1, dfrA10, tet(A), tet(B), tet(C), tet(D), tet(G), and tetR.
Evidence of antimicrobial resistance-conferring genetic elements among pneumococci isolated prior to 1974.
The study identified two Tn 916-like, tet(M)-containing elements in pneumococci isolated in 1967 and 1968, and a novel composite ICE, ICE Sp PN1, in a pneumococcus isolated in 1972. These elements contained genes conferring resistance to tetracycline and chloramphenicol.
Antibiotic resistance of bacteria isolated from the internal organs of edible snow crabs.
The study identified the catA1 gene, which confers resistance to chloramphenicol, in various bacterial isolates from the internal organs of edible snow crabs. This gene was detected in Acinetobacter spp. and Pseudomonas spp., indicating the presence of antibiotic-resistant bacteria in these crustaceans.
Chloramphenicol acetyltransferase as a selection marker for chlamydial transformation.
The study demonstrates that the chloramphenicol acetyltransferase (CAT) gene can be used as a selection marker for chlamydial transformation, providing an alternative to β-lactamase-based markers.
Engineered short branched-chain acyl-CoA synthesis in E. coli and acylation of chloramphenicol to branched-chain derivatives.
The study reports the successful engineering of E. coli to synthesize short branched-chain acyl-CoAs and utilize the cat gene to acylate chloramphenicol to branched-chain derivatives.
The innate growth bistability and fitness landscapes of antibiotic-resistant bacteria.
The study identifies the cat gene encoding chloramphenicol acetyltransferase as a key factor in conferring resistance to chloramphenicol in E. coli, demonstrating growth bistability in antibiotic-resistant strains.
Title of the Paper
The study characterizes antibiotic-resistant Staphylococcus aureus strains (EryR, KanR, TetR) and demonstrates that sub-curative antibiotic doses can selectively expand resistant bacterial populations during infection.
Shifts in geographic distribution and antimicrobial resistance during a prolonged typhoid fever outbreak--Bundibugyo and Kasese Districts, Uganda, 2009-2011.
The study reports a high prevalence of multidrug-resistant (MDR) Salmonella Typhi isolates during a prolonged typhoid fever outbreak in Uganda, with 83% of 18 isolates being MDR. It also notes an increase in antimicrobial resistance compared to 2009 isolates.
Isolation of Escherichia coli strains with AcrAB-TolC efflux pump-associated intermediate interpretation or resistance to fluoroquinolone, chloramphenicol and aminopenicillin from dogs admitted to a university veterinary hospital.
The study identified blaTEM-1 and catA1 as key resistance genes in E. coli isolates from dogs, along with QRDR mutations in gyrA and parC contributing to fluoroquinolone resistance.
Invasive Salmonella enterica serotype typhimurium infections, Democratic Republic of the Congo, 2007-2011.
The study identifies the mph(A) gene encoding a macrolide 2'-phosphotransferase and the cat gene conferring chloramphenicol resistance in Salmonella enterica serotype Typhimurium isolates from the Democratic Republic of the Congo.
Diverse antibiotic resistance genes in dairy cow manure.
The study identified 80 unique antibiotic resistance genes in dairy cow manure, including a novel clade of chloramphenicol acetyltransferases and several beta-lactamases, tetracycline resistance genes, and aminoglycoside-modifying enzymes.
Epidemiology and molecular characterization of methicillin-resistant Staphylococcus aureus nasal carriage isolates from bovines.
The study identified multiple AMR genes in MRSA isolates from bovines, including blaZ, blaI, blaR, tetM, ermC, aacA-aphD, aadD, aphA3, cat, sdrM, and fosB, which confer resistance to penicillin, tetracycline, erythromycin, gentamicin, kanamycin, chloramphenicol, and fosfomycin.
Characterization of microbiota composition and presence of selected antibiotic resistance genes in carriage water of ornamental fish.
The study identified several antibiotic resistance genes including sul1, tet(A), strA, aadA, cat, tet(G), and sul2 in the microbiota of ornamental fish carriage water. These genes were found to be prevalent and associated with various bacterial families.
Genomic signature of multidrug-resistant Salmonella enterica serovar typhi isolates related to a massive outbreak in Zambia between 2010 and 2012.
The study identifies multiple antimicrobial resistance genes in multidrug-resistant Salmonella enterica serovar Typhi isolates from Zambia, including strA, strB, blaTEM-1, sul1, sul2, dfrA7, and catA1. Mutations in the gyrA gene were also associated with fluoroquinolone resistance.
Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin.
The study identified various AMR genes, including bla TEM, dfr, strB, tet(A), and tet(B), in Gram-negative fecal bacteria from volunteers treated with amoxicillin, minocycline, or placebo. The prevalence of these genes increased significantly in the amoxicillin-treated group.
Antimicrobial Resistance Mechanisms in Salmonella and Other Bacteria
The paper discusses multidrug efflux pumps from various bacterial food pathogens including Enterobacteriaceae, Vibrio cholerae, and Staphylococcus aureus, highlighting their role in multidrug resistance.
Thermoadaptation-directed evolution of chloramphenicol acetyltransferase in an error-prone thermophile using improved procedures
The study reports the generation of a thermostable variant of chloramphenicol acetyltransferase (CAT) from Staphylococcus aureus, designated CAT A138T, which confers increased chloramphenicol resistance in Geobacillus kaustophilus.
Clinical epidemiology and molecular analysis of extended-spectrum-β-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types 131 and 648.
The study identified bla CTX-M-15, aac (3)-IIa, aadA1, aadA2, aadA5, qnrB4, qnrS1, aac (6')-Ib-cr, bla OXA-1, bla TEM-1B, bla SHV-12, bla CMY-42, bla DHA-1, mphA, ermB, catA1, catB3, sul1, sul2, dfrA12, dfrA17, dfrA1, dfrA5, tetA, tetB, and tetD as key AMR genes in ESBL-producing E. coli isolates in Nepal, highlighting the prevalence of multidrug resistance.
Phage-mediated horizontal transfer of a Staphylococcus aureus virulence-associated genomic island.
The study demonstrates the phage-mediated transfer of the Staphylococcus aureus genomic island νSaβ, which includes the tetracycline resistance gene tetM and the chloramphenicol resistance gene cat.
Metronidazole- and Carbapenem-Resistant Bacteroides thetaiotaomicron Isolated in Rochester, Minnesota, in 2014.
The study identifies multiple antimicrobial resistance genes in a metronidazole- and carbapenem-resistant Bacteroides thetaiotaomicron isolate, including nimD, cat, tetX, tetQ, ermF, and a novel beta-lactamase gene.
Healthcare- and Community-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) and Fatal Pneumonia with Pediatric Deaths in Krasnoyarsk, Siberian Russia: Unique MRSA's Multiple Virulence Factors, Genome, and Stepwise Evolution.
The study identifies multiple antimicrobial resistance genes in MRSA strains from Krasnoyarsk, Siberian Russia, including mecA, blaZ, ermA, ermC, cat, aacA-aphD, aadD, tet, spc, ble, qacA, cad, and mer, which confer resistance to various antibiotics such as methicillin, ampicillin, erythromycin, clindamycin, chloramphenicol, gentamicin, kanamycin, tetracycline, spectinomycin, bleomycin, quaternary ammonium compounds, cadmium, and mercury.
An outbreak of colistin-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in the Netherlands (July to December 2013), with inter-institutional spread.
The study describes an outbreak of colistin-resistant KPC-producing K. pneumoniae ST258 in the Netherlands, highlighting the presence of multiple resistance genes including blaKPC-2, blaSHV-12, and various other AMR genes.
Synthesis and evaluation of chloramphenicol homodimers: molecular target, antimicrobial activity, and toxicity against human cells.
The study focused on synthesizing and evaluating chloramphenicol (CAM) homodimers, particularly compound 5, which showed enhanced antimicrobial activity against certain CAM-resistant strains and lower toxicity compared to CAM.
Evolution of AbGRI2-0, the Progenitor of the AbGRI2 Resistance Island in Global Clone 2 of Acinetobacter baumannii.
The study identifies several AMR genes in the A320 strain of Acinetobacter baumannii, including blaTEM, aacC1, aadA1, sul1, catA1, and aphA1b, which confer resistance to various antibiotics.
Genomic and Functional Characterization of qnr-Encoding Plasmids from Municipal Wastewater Biosolid Klebsiella pneumoniae Isolates.
The study identified two types of plasmids harboring qnr genes in Klebsiella pneumoniae isolates from municipal wastewater biosolids. One plasmid, pKPSH-11XL, was a large multidrug-resistant IncF plasmid containing qnrB, beta-lactamase genes, tetracycline resistance genes, aminoglycoside resistance genes, and chloramphenicol resistance genes. Another group of smaller plasmids contained qnrS and other resistance genes.
Draft Genome Sequence of Proteus mirabilis NO-051/03, Representative of a Multidrug-Resistant Clone Spreading in Europe and Expressing the CMY-16 AmpC-Type β-Lactamase.
The draft genome sequence of Proteus mirabilis NO-051/03 reveals the presence of multiple acquired resistance genes, including blaCMY-16 and blaTEM-1b, which confer resistance to β-lactams, as well as genes for resistance to aminoglycosides, chloramphenicol, tetracyclines, trimethoprim, and sulfonamides. Additionally, mutations in gyrA, gyrB, and parC contribute to fluoroquinolone resistance.
Draft Genome Sequence of Proteus mirabilis NO-051/03, Representative of a Multidrug-Resistant Clone Spreading in Europe and Expressing the CMY-16 AmpC-Type β-Lactamase.
The draft genome sequence of Proteus mirabilis NO-051/03 reveals the presence of multiple acquired resistance genes, including blaCMY-16 and blaTEM-1b, which confer resistance to β-lactams, as well as genes for resistance to aminoglycosides, chloramphenicol, tetracyclines, trimethoprim, and sulfonamides. Additionally, mutations in gyrA, gyrB, and parC contribute to fluoroquinolone resistance.
Genome Sequence of Riemerella anatipestifer Strain RCAD0122, a Multidrug-Resistant Isolate from Ducks.
The genome sequence of Riemerella anatipestifer strain RCAD0122 reveals the presence of nine types of antibiotic resistance-associated genes, including those encoding resistance to beta-lactams, fluoroquinolones, chloramphenicol, lincosamides, sulfonamides, aminoglycosides, tetracyclines, glycopeptides, and macrolides.
Antibiotic Resistance, Core-Genome and Protein Expression in IncHI1 Plasmids in Salmonella Typhimurium.
The study identified multiple antibiotic resistance genes in IncHI1 plasmids of Salmonella Typhimurium, including tet(B), tet(A), blaTEM, strA, strB, sul2, aadA, dfrA, catA1, aphA1a, and aad(3)IId, which confer resistance to various antibiotics such as tetracycline, beta-lactam, streptomycin, sulfonamide, aminoglycoside, chloramphenicol, and trimethoprim.
Characterisation of Phenotypic and Genotypic Antibiotic Resistance Profile of Enterococci from Cheeses in Turkey.
The study identified several antibiotic resistance genes in enterococci from Turkish cheeses, including ermB, tetM, aph(3')-IIIa, cat, and aac(6')-Ieaph(2")-Ia, which confer resistance to macrolides, lincosamides, streptogramin B, tetracycline, kanamycin, gentamicin, and chloramphenicol.
Corrected Genome Annotations Reveal Gene Loss and Antibiotic Resistance as Drivers in the Fitness Evolution of Salmonella enterica Serovar Typhimurium.
The study identifies antibiotic resistance genes and genomic islands in Salmonella enterica serovar Typhimurium, highlighting the role of horizontal gene transfer in the acquisition of multidrug resistance and fitness-related genes.
Shifts in the Clonal Distribution of Methicillin-Resistant Staphylococcus aureus in Kuwait Hospitals: 1992-2010.
The study identified various AMR genes in MRSA isolates from Kuwait hospitals, including aphA3, aacA-aphD, ermA, ermC, mupA, tetK, tetM, fusC, far1, msrA, mphC, sat, qacA, qacC, merA, merB, dfrS1, aadD, fosB, cat, sdrM, icaA, icaC, and icaD, which conferred resistance to multiple antibiotics.
Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes.
The study introduces SEER, a computational method for identifying sequence elements associated with bacterial phenotypes, including antibiotic resistance. It confirms known resistance mechanisms such as cat for chloramphenicol, tetM for tetracycline, and pbp genes for beta-lactam resistance, as well as identifies new potential factors related to S. pyogenes invasiveness.
Architecture of Class 1, 2, and 3 Integrons from Gram Negative Bacteria Recovered among Fruits and Vegetables.
The study identified several AMR genes in Gram-negative bacteria from fresh produce, including mcr-1, qnrA1, blaGES-11, mphA, and oqxAB, highlighting the presence of mobile genetic elements and clinically relevant resistance genes.
Comparative genomics of Clostridium bolteae and Clostridium clostridioforme reveals species-specific genomic properties and numerous putative antibiotic resistance determinants.
The study identified numerous antibiotic resistance genes in Clostridium bolteae and Clostridium clostridioforme, including beta-lactamases, glycopeptide resistance operons, macrolide and lincosamide resistance genes, and efflux pumps. Notably, C. bolteae 90B3 exhibited resistance to linezolid, chloramphenicol, florfenicol, and tiamulin due to the presence of the 23S rRNA methyltransferase gene cfr. Additionally, C. clostridioforme 90A8 possessed a VanB-type operon conferring vancomycin resistance.
Bacterial viruses enable their host to acquire antibiotic resistance genes from neighbouring cells.
The study demonstrates that prophages in Staphylococcus aureus can facilitate the transfer of antibiotic resistance genes from neighboring cells through a process called 'autotransduction.' Resistance genes such as ermB, cat, and tetM were successfully transferred.
Comparative Genome Analysis of Extended-Spectrum-β-Lactamase-Producing Escherichia coli Sequence Type 131 Strains from Nepal and Japan.
The study identified multiple AMR genes, including blaCTX-M-15, blaOXA-1, aac(6')-Ib-cr, tet(A), mphA, strA, strB, aadA5, sul1, sul2, dfrA12, dfrA17, catA1, and catB3, in ESBL-producing E. coli ST131 isolates from Nepal and Japan. These genes conferred resistance to various antibiotics, including β-lactams, aminoglycosides, tetracyclines, macrolides, sulfonamides, and chloramphenicol.
Whole-Genome Analysis of Antimicrobial-Resistant and Extraintestinal Pathogenic Escherichia coli in River Water.
The study identified numerous antimicrobial resistance genes in Escherichia coli isolates from river water, highlighting the presence of multidrug-resistant and extraintestinal pathogenic strains. Key resistance genes included blaTEM-1, aac(3)-IId, qnrB7, and others.
Collective Resistance in Microbial Communities by Intracellular Antibiotic Deactivation.
The study identifies the cat gene, encoding chloramphenicol acetyltransferase, as a key player in providing passive resistance to chloramphenicol in Streptococcus pneumoniae through intracellular deactivation of the antibiotic.
Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.).
The study identified various AMR genes and mutations in Enterococcus faecalis isolates from macaque cephalic implants, highlighting the presence of high-level aminoglycoside resistance, tetracycline resistance, and bacitracin resistance. These findings emphasize the complexity of AMR in clinical settings and the need for targeted antimicrobial strategies.
Marine Bivalve Mollusks As Possible Indicators of Multidrug-Resistant Escherichia coli and Other Species of the Enterobacteriaceae Family.
The study identified multiple AMR genes in E. coli isolates from marine bivalves, including bla TEM-1, bla CTX-M-14, bla CTX-M-15, and various aminoglycoside, trimethoprim, sulfonamide, tetracycline, chloramphenicol, quinolone, and macrolide resistance genes. These findings highlight the potential risk of MDR Enterobacteriaceae in marine environments.
Experimental evolution of a synthetic cat gene reveals mechanisms of clonal interference and multi-level selection
The study characterizes the evolution of plasmid-borne antibiotic resistance genes, focusing on the chloramphenicol resistance gene (cat) and the ampicillin resistance gene (bla). It identifies mutations in the plasmid that contribute to resistance and highlights the role of clonal interference in plasmid evolution.
Type B Chloramphenicol Acetyltransferases Are Responsible for Chloramphenicol Resistance in Riemerella anatipestifer, China.
The study identifies two copies of the cat gene in R. anatipestifer CH-2, which are responsible for chloramphenicol resistance. The H79A mutation in the cat gene abolishes CAT activity and reduces resistance.
Region-specific diversification of the highly virulent serotype 1 Streptococcus pneumoniae.
The study identifies tetracycline resistance gene tetM and chloramphenicol resistance gene cat in serotype 1 Streptococcus pneumoniae isolates, highlighting regional variations in antimicrobial resistance profiles.
Genomic Analysis of Factors Associated with Low Prevalence of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli Sequence Type 95 Strains.
The study identifies several AMR genes in ST95 E. coli strains, including blaTEM-1, blaCTX-M14, aadA1, aadA2, aadA5, aac3, strA, strB, tetA, tetB, tetD, sul1, sul2, dfrA5, dfrA12, dfrA17, mphA, and catA1, which confer resistance to various antibiotics such as ampicillin, cephalothin, streptomycin, tetracycline, sulfamethoxazole, trimethoprim, azithromycin, and chloramphenicol.
Genome sequence of Shigella flexneri strain SP1, a diarrheal isolate that encodes an extended-spectrum β-lactamase (ESBL).
The study identifies the presence of multiple antibiotic resistance genes in the Shigella flexneri strain SP1, including blaCTX-M-14, blaOXA-1, aadA24, strA, strB, catA1, tetD, sul2, and dfrA1, which contribute to its multidrug-resistant phenotype.
Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.
The study identified 46 AMR genes or gene families in 90 Klebsiella pneumoniae isolates from Kenya, highlighting the prevalence of multidrug resistance and the diversity of resistance mechanisms.
Genomic Analysis of Multidrug-Resistant Escherichia coli from North Carolina Community Hospitals: Ongoing Circulation of CTX-M-Producing ST131-H30Rx and ST131-H30R1 Strains.
The study identified multiple AMR genes and mutations in multidrug-resistant E. coli isolates from North Carolina community hospitals, including bla CTX-M-15, bla CTX-M-14, aac(6′)-Ib-cr, qnrS1, and mutations in gyrA, parC, and parE that confer resistance to various antibiotics.
Characterization of the emerging zoonotic pathogen Arcobacter thereius by whole genome sequencing and comparative genomics.
The study characterizes the genome of Arcobacter thereius, identifying metabolic pathways and potential antibiotic resistance mechanisms. No specific AMR genes were experimentally validated in this study.
Unusual acylation of chloramphenicol in Lysobacter enzymogenes, a biocontrol agent with intrinsic resistance to multiple antibiotics.
Lysobacter enzymogenes exhibits intrinsic resistance to chloramphenicol through the production of unusual acyl derivatives, including chloramphenicol-3'-isobutyrate, chloramphenicol-1'-isobutyrate, and chloramphenicol-3'-isovalerate. The cat gene, encoding chloramphenicol acetyltransferase, plays a role in this resistance mechanism.
Construction of novel pJRD215-derived plasmids using chloramphenicol acetyltransferase (cat) gene as a selection marker for Acidithiobacillus caldus.
Chloramphenicol was proven to be an effective selection marker for Acidithiobacillus caldus. The cat gene, encoding chloramphenicol acetyltransferase, was utilized to construct novel plasmids with improved transformation efficiency and biosafety.
Transcriptional Response of Resistome to Composting and Its Implications for Antimicrobial Resistance Dissemination
The study identifies several tetracycline resistance genes (tetM, tetW, tetO, tetS), sulfonamide resistance genes (sulI, sulII), and others, showing their expression dynamics during composting and their association with microbial community shifts.
The clinical and microbiological characteristics of enteric fever in Cambodia, 2008-2015.
The study identified various AMR genes and mutations in Salmonella Typhi and Salmonella Paratyphi A isolates from Cambodia, including beta-lactamase (blaTEM-1B), chloramphenicol acetyltransferase (catA1), sulfonamide resistance proteins (sul1, sul2), dihydrofolate reductase (dfrA7), tetracycline resistance protein (tet(B)), and streptomycin resistance protein (strAB). Additionally, mutations in the gyrA and gyrB genes were associated with decreased ciprofloxacin susceptibility.
Assessment of antibiotic susceptibility in Lactobacillus isolates from chickens.
The study identified several tetracycline, macrolide, and aminoglycoside resistance genes in Lactobacillus isolates from chickens, highlighting the presence of resistance mechanisms in these bacteria.
Rapid Nanopore Sequencing of Plasmids and Resistance Gene Detection in Clinical Isolates.
The study demonstrates the feasibility of rapid nanopore sequencing for detecting plasmid-borne antimicrobial resistance (AMR) genes in clinical isolates. It identifies several AMR genes, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, tetracycline resistance genes, macrolide resistance genes, and phenicol resistance genes, in both Escherichia coli and Klebsiella pneumoniae isolates.
Genome sequencing and analysis of the first spontaneous Nanosilver resistant bacterium Proteus mirabilis strain SCDR1.
The study identifies several AMR genes in the Nanosilver-resistant Proteus mirabilis strain SCDR1, including those conferring resistance to tetracycline, fluoroquinolones, sulfonamides, daptomycin, rifamycin, elfamycins, chloramphenicol, and amikacin.
The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies.
The study explores the complex resistomes of Paenibacillaceae, revealing diverse antibiotic resistance mechanisms including intrinsic and acquired resistance genes such as aadD2, vanA, vanB, vanC, vanD, vanE, vanF, vanG, mcr, bla, tet, qnr, erm, mph, lnu, lsa, vat, vgb, cat, cfr, optrA, poxtA, sul, dfr, mexAB-OprM, acrAB-TolC, and oqxAB.
Genetic characterization of phenicol-resistant Escherichia coli and role of wild-type repressor/regulator gene ( acrR ) on phenicol resistance.
The study identifies several phenicol resistance genes (catA1, catA2, flo, flo-R) and highlights the role of acrR mutations in increasing phenicol resistance through overexpression of the AcrAB efflux pump.
Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population.
The study identifies clinically relevant ESBL-producing K. pneumoniae ST307 and E. coli ST38 in an urban West African rat population, highlighting the presence of multidrug-resistant strains carrying various resistance genes such as blaCTX-M-15, blaCTX-M-14, blaCTX-M-9, and others.
Genome Sequencing of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in Cameroon.
The study identified multiple antibiotic resistance genes in ESBL-producing K. pneumoniae isolates from pigs and abattoir workers in Cameroon, including bla CTX-M-15, bla TEM-1B, bla SHV-28, and others, highlighting the presence of multidrug-resistant strains and their potential for zoonotic transmission.
Genetic Determinants of Tetracycline Resistance in Clinical Streptococcus pneumoniae Serotype 1 Isolates from Niger.
Clinical Streptococcus pneumoniae serotype 1 isolates from Niger exhibited high tetracycline resistance (77.4%) primarily due to the presence of the tet(M) gene within a defective Tn5253-like transposon. One isolate was also resistant to chloramphenicol due to the presence of a cat gene.
Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy.
The study identified multiple AMR genes and mutations in Salmonella Typhi and Salmonella Paratyphi A isolates from Nepal, including gyrA and parC mutations associated with fluoroquinolone resistance, and acquired AMR genes such as catA1, dfrA7, sul1, sul2, strA, strB, and blaTEM-1 associated with multidrug resistance.
Detection of antimicrobial resistance-associated proteins by titanium dioxide-facilitated intact bacteria mass spectrometry.
The study demonstrates the successful detection of antimicrobial resistance-associated proteins using TiO2-facilitated MALDI-TOF MS without sample pre-treatment. Specific resistance proteins such as blaTEM-1, aacC1, cat, and ampC were identified in various bacterial strains.
The Use of a Combined Bioinformatics Approach to Locate Antibiotic Resistance Genes on Plasmids From Whole Genome Sequences of Salmonella enterica Serovars From Humans in Ghana.
The study identified several AMR genes in Salmonella isolates from Ghana, including blaTEM-1B, blaTEM-52B, blaCTX-M-15, tet(A), dfrA15, sul1, sul2, catA1, strA, strB, aadA1, catB3, qnrB1, aac(6')Ib-cr, and blaOXA-1. These genes were found on various plasmids, highlighting the diversity of resistance mechanisms in the studied isolates.
High genomic diversity of multi-drug resistant wastewater Escherichia coli.
The study identifies several known and novel resistance genes in wastewater-derived E. coli, highlighting the high genomic diversity and the presence of genes associated with resistance to various antibiotics.
Characterization of Wild and Captive Baboon Gut Microbiota and Their Antibiotic Resistomes.
The study identified antibiotic resistance genes in wild and captive baboon gut microbiota, revealing that captive baboons had higher diversity and abundance of resistance genes compared to wild baboons, suggesting potential human-mediated transmission of resistance traits.
Spread and Persistence of Virulence and Antibiotic Resistance Genes: A Ride on the F Plasmid Conjugation Module.
The paper reviews the role of F-like plasmids in the spread and persistence of antibiotic resistance and virulence genes, highlighting the importance of these plasmids in the dissemination of resistance genes such as blaTEM-1, sul1, aadA, and catA1, as well as virulence factors like ompP and colicin genes.
Antimicrobial Susceptibility Testing and Tentative Epidemiological Cutoff Values for Five Bacillus Species Relevant for Use as Animal Feed Additives or for Plant Protection.
The study identified several antimicrobial resistance genes in five Bacillus species, including a putative chloramphenicol acetyltransferase (cat) gene in Bacillus megaterium, a tetracycline efflux gene (tet(L)) in Bacillus velezensis and Bacillus amyloliquefaciens, and an erythromycin resistance gene (ermD) in Bacillus paralicheniformis and Bacillus licheniformis.
Myroides odoratimimus urinary tract infection in an immunocompromised patient: an emerging multidrug-resistant micro-organism.
The study identifies multiple AMR genes in Myroides odoratimimus, including bla-OXA-347, bla-OXA-209, tetX, and cat, which contribute to its multidrug-resistant profile.
Selective advantage of deletions enhancing chloramphenicol acetyltransferase gene expression in Streptococcus pneumoniae plasmids.
The study identified that deletions in plasmids pJS3 and pJS5 led to enhanced expression of the cat gene, which confers resistance to chloramphenicol. The deletions resulted in higher levels of chloramphenicol acetyltransferase (CAT) production, providing a selective advantage under chloramphenicol stress.
Cloning and expression of a chloramphenicol acetyltransferase gene in cytosine-substituted T4 bacteriophage.
The study describes the successful cloning and expression of a chloramphenicol acetyltransferase gene (cat) in a cytosine-substituted T4 bacteriophage, demonstrating that the gene confers resistance to chloramphenicol.
Variant O89 O-Antigen of E. coli Is Associated With Group 1 Capsule Loci and Multidrug Resistance.
The study identified a novel O89 O-antigen locus in E. coli strain 26561, which is associated with group 1 capsule (G1C) and multidrug resistance. The strain exhibits a mucoid and viscous phenotype, and possesses multiple AMR genes including blaCTX-M-14, blaTEM-1, aph(3")-Ib, strA, aph(6)-Id, strB, aph(3′)-Ia, sul2, tetA(B), and catA1. Mutations in gyrA (S83L, D87N) and parC (S80I) contribute to quinolone resistance.
Biofilm Formation Drives Transfer of the Conjugative Element ICEBs1 in Bacillus subtilis.
Biofilm formation significantly enhances the conjugative transfer of the integrative and conjugative element (ICE) ICEBs1 in Bacillus subtilis. The study demonstrates that biofilm matrix production is critical for efficient ICEBs1 transfer, highlighting the role of biofilm structure in facilitating horizontal gene transfer.
The Genetic Transformation of Chlamydia pneumoniae.
The study established a novel plasmid shuttle vector system for the genetic transformation of Chlamydia pneumoniae, demonstrating stable retention of the plasmid and expression of RSGFP in various C. pneumoniae isolates, including human and animal strains.
Occurrence and characterization of methicillin-resistant Staphylococcus pseudintermedius in successive parturitions of bitches and their puppies in two kennels in Italy.
The study identified multiple methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains in two Italian kennels, highlighting the presence of various resistance mechanisms including beta-lactam, aminoglycoside, macrolide, tetracycline, and chloramphenicol resistance genes.
Antimicrobial Resistance in Lactobacillus Species: A Genomic and Phenotypic Analysis
The study identifies various tetracycline, erythromycin, chloramphenicol, and aminoglycoside resistance genes in Lactobacillus species, highlighting their potential role in antimicrobial resistance and horizontal gene transfer.
Identification and antibiotic susceptibility of lactobacilli isolated from turkeys.
The study identified several tetracycline, macrolide, and lincosamide resistance genes in turkey-derived lactobacilli, including tetL, tetM, tetW, ermB, ermC, lnuA, aadE, ant(6)-Ia, cat, and lsaE. These genes were associated with resistance to tetracycline, erythromycin, lincomycin, streptomycin, chloramphenicol, and tiamulin.
Salmonella enterica Serovar Typhi in Bangladesh: Exploration of Genomic Diversity and Antimicrobial Resistance.
The study identified several AMR genes and mutations in S. Typhi isolates from Bangladesh, including blaTEM-1B, blaCTX-M-15, catA1, dfrA7, sul1, sul2, qnrS1, strA, strB, tet(A), tet(B), and mutations in gyrA and parE associated with ciprofloxacin resistance.
The Pseudomonas aeruginosa Pan-Genome Provides New Insights on Its Population Structure, Horizontal Gene Transfer, and Pathogenicity.
The study identifies the chloramphenicol acetyltransferase gene (cat) and the outer membrane porin gene (oprA) as lineage-specific resistance genes in P. aeruginosa, highlighting their association with specific population groups.
The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.
The study identifies multiple AMR genes associated with multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa, including genes encoding resistance to aminoglycosides, beta-lactams, chloramphenicol, trimethoprim, sulfonamides, and tetracyclines. It also notes mutations in the gyrA gene associated with reduced susceptibility to fluoroquinolones.
A Population-Based Descriptive Atlas of Invasive Pneumococcal Strains Recovered Within the U.S. During 2015-2016.
The study identifies multiple AMR genes and mutations in Streptococcus pneumoniae isolates, including ermB, mef, folA, and folP, which confer resistance to macrolides, trimethoprim, and penicillin. Mutations in pbp2x and pbp1a are associated with penicillin resistance.
Putative antibiotic resistance genes present in extant Bacillus licheniformis and Bacillus paralicheniformis strains are probably intrinsic and part of the ancient resistome.
The study identified intrinsic antibiotic resistance genes in Bacillus licheniformis and Bacillus paralicheniformis, including ermD for erythromycin resistance, aadK and aph for streptomycin resistance, and cat for chloramphenicol resistance. These genes were found to be part of the ancient resistome and not horizontally transferred.
Genome Analysis of Shigella flexneri Serotype 3b Strain SFL1520 Reveals Significant Horizontal Gene Acquisitions Including a Multidrug Resistance Cassette.
The study identifies a multidrug resistance cassette in Shigella flexneri serotype 3b strain SFL1520, including genes tetDCAR, cat, dhfrI, and ant1, which confer resistance to tetracycline, chloramphenicol, trimethoprim, and streptomycin.
Whole-genome sequences of multidrug-resistant Escherichia coli in South-Kivu Province, Democratic Republic of Congo: characterization of phylogenomic changes, virulence and resistance genes.
The study characterizes multidrug-resistant Escherichia coli isolates from South-Kivu Province, Democratic Republic of Congo, identifying several AMR genes including blaCTX-M-15, blaTEM-1, blaOXA-1, aac(6')-Ib, qnrS1, cat, sulI, sulII, tet(A), and dhfr. It also identifies chromosomal mutations in gyrA and parC contributing to quinolone resistance.
Cross-Border Transmission of Salmonella Choleraesuis var. Kunzendorf in European Pigs and Wild Boar: Infection, Genetics, and Evolution.
The study identified multiple antimicrobial resistance genes in Salmonella Choleraesuis isolates, including aadA1, catA1, cmlA1, floR, mph(B), strA, strB, sul1, sul2, sul3, tet(A), tet(B), dfrA1, aph(3')-Ia, lnu(B), and blaTEM-1. These genes conferred resistance to various antibiotics such as streptomycin, chloramphenicol, florfenicol, erythromycin, sulfamethoxazole, tetracycline, trimethoprim, gentamicin, lincomycin, and ampicillin.
Characterisation of antibiotic resistance of Salmonella isolated from dog treats in Japan.
The study identified the presence of antibiotic-resistant Salmonella in dog treats in Japan, including the blaTEM gene, aadA1, aadA2, tetB, floR, catA1, dfrA12, and intI1 genes, indicating multidrug resistance.
Draft Genome Sequence of an Enterococcus faecalis Strain (24FS) That Was Isolated from Healthy Infant Feces and Exhibits High Antibacterial Activity, Multiple-Antibiotic Resistance, and Multiple Virulence Factors.
The study reports the draft genome sequence of Enterococcus faecalis 24FS, highlighting its multiple-antibiotic resistance traits, including resistance to chloramphenicol, tetracycline, erythromycin, aminoglycosides, fluoroquinolones, trimethoprim, streptothricin, and streptomycin, along with potential virulence factors.
Independent Microevolution Mediated by Mobile Genetic Elements of Individual Clostridium difficile Isolates from Clade 4 Revealed by Whole-Genome Sequencing.
The study identified multiple antimicrobial resistance genes, including aac(6')-Ib, ermB, tetM, and catD, in Clostridium difficile isolates from clade 4, highlighting the role of mobile genetic elements in the evolution of multidrug resistance.
Whole Genome Sequencing of Extended Spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae Isolated from Hospitalized Patients in KwaZulu-Natal, South Africa.
The study characterized multiple AMR genes in ESBL-producing K. pneumoniae isolates, including bla TEM-1B, bla CTX-M-15, bla SHV-1, bla OXA-1, aad AI6, aac (6′)Ib-cr, aph (6)Id, aph (3′)-Ib, oqx A, oqx B, fos A, ARR-3, sul 1, sul 2, dfr A14, dfr A27, cat A1, and cat B4.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
Global phylogenomics of multidrug-resistant Salmonella enterica serotype Kentucky ST198.
The study identifies multiple AMR genes and mutations in multidrug-resistant Salmonella enterica serotype Kentucky ST198, including genes such as blaTEM-1, aacA4, aadA1, sul1, tetA, catA1, mph(A), blaCTX-M-1, blaOXA-48, blaNDM-1, blaCMY-2, and dfrA12, along with mutations in gyrA and parC that confer resistance to various antibiotics.
Identification of Escherichia coli from broiler chickens in Jordan, their antimicrobial resistance, gene characterization and the associated risk factors.
The study identified several antimicrobial resistance genes in Escherichia coli isolates from broiler chickens in Jordan, including tetA, tetB, int1, sul1, sul2, blaTEM, and cat. These genes were associated with resistance to various antibiotics such as tetracycline, sulfonamides, beta-lactams, and chloramphenicol.
Diverse Commensal Escherichia coli Clones and Plasmids Disseminate Antimicrobial Resistance Genes in Domestic Animals and Children in a Semirural Community in Ecuador.
The study identified various antimicrobial resistance (AMR) genes in commensal Escherichia coli isolates from children and domestic animals in a semirural community in Ecuador. These genes included blaTEM-1B, dfrA8, qnrB19, strA, strB, tetA, tetB, sul1, sul2, and others, contributing to resistance against multiple antibiotics such as ampicillin, trimethoprim, tetracycline, and sulfamethoxazole. The research highlights the role of plasmids in disseminating these AMR genes and emphasizes the complexity of AMR transmission in such environments.
Ceftriaxone-resistant Salmonella enterica serotype Typhi in a pregnant traveller returning from Karachi, Pakistan to Denmark, 2019.
The study reports a ceftriaxone-resistant Salmonella Typhi isolate carrying multiple resistance genes, including blaCTX-M-15, blaTEM-1B, qnrS1, sul1, sul2, dfrA7, aph[3]-1b, aph[6]-1d, aac[6]-1aa, and catA1. Additionally, a fluoroquinolone resistance mutation (gyrA S83F) was identified.
Antimicrobial resistance, virulence & plasmid profiles among clinical isolates of Shigella serogroups.
The study identified multiple antimicrobial resistance genes including bla OXA-1, bla TEM-1B, qnr S1, dfr A1, aad A1, sul II, tet B, and cat A1 in Shigella isolates. Additionally, novel mutations in gyr A, gyr B, par C, and par E genes were observed, contributing to quinolone resistance.
Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods.
The study identified various AMR genes and mutations in Salmonella enterica serovar Typhimurium, including aadA, strAB, blaTEM, blaCARB, floR, cmlA1, catA1, qnrB19, sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, tetA, tetB, tetC, tetG, and mutations in gyrA. These genes and mutations were validated through whole genome sequencing and phenotypic ASTs.
Whole genome sequencing revealed new molecular characteristics in multidrug resistant staphylococci recovered from high frequency touched surfaces in London.
The study identified several AMR genes in multidrug-resistant staphylococci from high-frequency touched surfaces in London, including blaZ, qacA/B, dfrC, norA, ant(4')-Ib, AAC(6')-Ie-APH(2")-Ia, fusB, msrA, ermC, mphC, tetK, mupA, cat, dfrG, lnuA, fusC, aph3-IIIa, sat4A, vgaA, and others. These genes conferred resistance to various antibiotics such as penicillin, fusidic acid, mupirocin, tetracycline, erythromycin, and chloramphenicol.
Molecular Epidemiology of Multidrug-Resistant Klebsiella pneumoniae Isolates in a Brazilian Tertiary Hospital.
The study identified various AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae isolates, including bla KPC, bla CTX-M, bla TEM, and mutations in ompk35, ompk36, gyrA, and parC. These findings highlight the complex resistance mechanisms contributing to the persistence of MDR-Kp in the hospital setting.
Characterization of Non-O157 Escherichia coli from Cattle Faecal Samples in the North-West Province of South Africa.
The study identified several antimicrobial resistance genes in non-O157 E. coli isolates from cattle fecal samples, including tetA, tetB, blaTEM-1, aadA1, and catA1, which were associated with resistance to tetracycline, ampicillin, streptomycin, and chloramphenicol.
Evolution of Outbreak-Causing Carbapenem-Resistant Klebsiella pneumoniae ST258 at a Tertiary Care Hospital over 8 Years.
The study identifies various AMR genes in ST258 K. pneumoniae isolates, including blaKPC-2, blaKPC-3, aadA2, aadA1, blaTEM-1A, blaSHV-11, blaSHV-12, oqxA, oqxB, fosA, dfrA12, dfrA14, sul1, sul2, catA1, cml, and strAB, which confer resistance to multiple antibiotics.
Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut.
The study identifies the cat gene as a key factor in conferring chloramphenicol resistance in Salmonella, facilitating plasmid transfer and persistence in the gut.
Antimicrobial Resistance Mechanisms in Antibiotic-Producing Bacteria and Pathogens
The paper discusses various antimicrobial resistance mechanisms in antibiotic-producing bacteria and pathogens, focusing on genes and mutations that confer resistance to different classes of antibiotics, including beta-lactams, aminoglycosides, tetracyclines, chloramphenicol, macrolides, and others.
Molecular characterization of carbapenem-resistant Klebsiella pneumoniae isolates with focus on antimicrobial resistance.
The study identifies blaKPC-2 as the dominant carbapenemase gene in clinical CRKP isolates, along with various ESBLs and other resistance genes such as blaCTX-M, blaTEM, blaSHV, aac(3)-IId, rmtB, QnrS1, oqxA, oqxB, fosA, catA1, catA2, dfrA1, and dfrA17.
The Resistome, Mobilome, Virulome and Phylogenomics of Multidrug-Resistant Escherichia coli Clinical Isolates from Pretoria, South Africa.
The study characterized the resistome, mobilome, and virulome of 20 multidrug-resistant E. coli isolates from Pretoria, South Africa. Key findings include the identification of various beta-lactamase genes (blaCTX-M-15, blaCTX-M-14, blaCTX-M-27, blaOXA-1, blaOXA-10, blaTEM-1B), aminoglycoside resistance genes (aac(3)-IIa, aac(3)-IId, aac(6')-Ib-cr, mph(A)), sulfonamide resistance genes (sul1, sul2, sul3), dihydrofolate reductase genes (dfrA17, dfrA14, dfrA1, dfrA5, dfrA7, dfrA12, dfrA23), tetracycline resistance genes (tet(A), tet(B)), chloramphenicol resistance genes (catB3, catA1), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE.
First Report of Coexistence of Three Different MDR Plasmids, and That of Occurrence of IMP-Encoding Plasmid in Leclercia adecarboxylata.
The study reports the first identification of three different multidrug-resistant (MDR) plasmids in a single clinical isolate of Leclercia adecarboxylata, including the blaIMP-8 gene encoded on an IMP-encoding plasmid. These plasmids harbor various AMR genes such as blaIMP-8, aacC2, aadA2, mph(A), sul1, qacED1, mer, chrA, dfrA12, tmrB, catA1, catB8, tet(C), blaCTX-M-9, and blaTEM-1.
Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Patients Admitted to Kuwait Hospitals in 2016-2017.
The study identified LA-MRSA isolates belonging to CC96, CC97, and CC398, with CC97 being the dominant clone. Resistance genes such as erm(A), erm(C), msr(A), aacA-aphD, fusC, tet(K), cat, and dfrS1 were detected, indicating multidrug resistance.
Comparative genomics of multidrug-resistant Enterococcus spp. isolated from wastewater treatment plants.
The study identified several AMR genes in multidrug-resistant Enterococcus spp. isolated from wastewater treatment plants, including vancomycin resistance genes (vanA, vanM, vanG, vanC), macrolide resistance genes (ermB, msrC), tetracycline resistance genes (tetL), aminoglycoside resistance genes (aad(6'), aac(6')-Ie-aph(2")-Ia, ant(9')-Ia, aph(3')-IIIa, SAT-4, ant(6')-Ia), chloramphenicol resistance gene (cat), dihydrofolate reductase genes (dfrE, dfrF, dfrG), and lincosamide resistance genes (InuB, InuG).
Evaluating the genome and resistome of extensively drug-resistant Klebsiella pneumoniae using native DNA and RNA Nanopore sequencing.
The study identified multiple AMR genes in extensively drug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (blaSHV-11, blaTEM-1B, blaVEB-1, blaOXA-10, blaKPC-2, blaOXA-9, blaVIM-27, blaCTX-M-15, blaOXA-1, blaOXA-48), aminoglycoside resistance genes (aadA1, ant(2'')-Ia, aph(6)-Id, arr-2, aadA24, aph(3')-Ia, aph(6)-Id, aac(3)-IIa, aac(6')Ib-cr, aac(6')-Ib, aac(6')-Ib-cr), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet(A), tet(G)), trimethoprim resistance genes (dfrA1, dfrA14, dfrA23), chloramphenicol resistance genes (cmlA1, catB4), and others.
Molecular characterization of avian pathogenic Escherichia coli from broiler chickens with colibacillosis.
The study identified several AMR genes in APEC isolates, including beta-lactamases (bla TEM-1, bla CTX-M-1, bla CTX-M-15), aminoglycoside-modifying enzymes (aac(3)-II), plasmid-mediated quinolone resistance genes (qnrA, qnrS), tetracycline resistance genes (tetA), sulfonamide resistance genes (sul2), and chloramphenicol resistance genes (catA1, cmlA).
Complete Nucleotide Sequence of Plasmids of Two Escherichia coli Strains Carrying bla (NDM-) (5) and bla (NDM) (-) (5) and bla (OXA) (-) (181) From the Same Patient.
The study characterizes two carbapenemase-producing E. coli strains carrying blaNDM-5 and blaOXA-181, along with various other resistance genes such as qnrS1, blaCTX-M-15, aac(6')-lb-cr, catB3, sul1, dfrA17, qacEΔ1, aadA5, rmtB, ermB, mphA, tetB, catA1, dfrA14, dfrA12, blaTEM-1B, and blaCMY-42.
Population structure and antimicrobial resistance patterns of Salmonella Typhi isolates in urban Dhaka, Bangladesh from 2004 to 2016.
Genome-Based Analysis of Extended-Spectrum β-Lactamase-Producing Escherichia coli in the Aquatic Environment and Nile Perch (Lates niloticus) of Lake Victoria, Tanzania.
The study identified multiple AMR genes in ESBL-producing E. coli from Nile perch and water samples in Lake Victoria, including bla CTX-M-15, bla TEM-1B, aadA2, aac(3)-IId, sul1, sul2, dfrA12, qepA4, tetB, tetD, mphA, mdfA, catA1, strA, strB, nfaE, iss, vat, and lpfA.
Genomic Insight into the Spread of Meropenem-Resistant Streptococcus pneumoniae Spain(23F)-ST81, Taiwan.
The study identifies pbp2b, pbp2x, and pbp1a as key genes contributing to meropenem resistance in Streptococcus pneumoniae, along with ermB, tetM, and cat as resistance genes. Mutations in PBP2b, PBP2x, and PBP1a were linked to increased meropenem resistance.
Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium.
The study identified 24 different antimicrobial-resistance determinants in Gallibacterium anatis isolates from calves with unresponsive bronchopneumonia, including novel resistance genes such as aadA23, blaCARB-8, tet(Y), and qnrD1.
Characterization of an IMP-4-Producing Klebsiella pneumoniae ST1873 Strain Recovered from an Infant with a Bloodstream Infection in China.
The study characterizes an IMP-4-producing Klebsiella pneumoniae ST1873 strain, identifying multiple antimicrobial resistance genes including blaIMP-4, blaSHV-2, blaSHV-11, oqxA, oqxB, aph(6)-Id, strA, catA1, dfrA5, sul2, and fosA.
International clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil.
The study identified various AMR genes in CTX-M-producing E. coli isolates from peri-urban wild animals in Brazil, including bla CTX-M-55, bla CTX-M-2, bla CTX-M-15, bla CTX-M-14, and others, indicating the presence of multidrug-resistant bacteria in wildlife.
Genomic Analysis of GC1 Strains from H1 Hospital
The study identifies various AMR genes in GC1 Group 1 and Outgroup Group 3 genomes, including aac(6')-Ib, aph(3')-Ia, aac(3)-IIa, sul1, sul2, tet(A), tet(G), catA1, intI1, intI2, and efflux pumps adeABC, adeIJK, and adeFGH. These genes contribute to multidrug resistance in Acinetobacter baumannii.
Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India.
The study identified several AMR genes and mutations in Salmonella Typhi isolates, including beta-lactamases (blaTEM-1B, blaTEM-116), chloramphenicol resistance gene (catA1), trimethoprim resistance genes (dfrA7, dfrA15), sulfamethoxazole resistance genes (sul1, sul2), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE genes.
Metagenomic Diagnosis for a Culture-Negative Sample From a Patient With Severe Pneumonia by Nanopore and Next-Generation Sequencing.
The study identified several AMR genes in a culture-negative sample from a patient with severe pneumonia, including bla SHV-12, bla KPC-2, bla TEM-1, bla CTX-M-65, aac(3)-IIa, aadA1, dfrA1, sul1, aph(3')-Ia, catA1, fosA, acrA, and rmtB, which confer resistance to various antibiotics.
Nanopore sequencing reveals genomic map of CTX-M-type extended-spectrum β-lactamases carried by Escherichia coli strains isolated from blue mussels (Mytilus edulis) in Norway.
The study identified CTX-M-type extended-spectrum beta-lactamases in Escherichia coli strains isolated from blue mussels in Norway, highlighting the potential for mobility of these resistance genes.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
The study identifies multiple AMR genes and mutations in MDR E. coli strains from captive wild animals, highlighting the presence of CTX-M-8 and CTX-M-65 beta-lactamases, along with various other resistance mechanisms such as aminoglycoside, tetracycline, and fluoroquinolone resistance genes, as well as mutations in quinolone resistance-determining regions.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
The study identified multiple AMR genes and mutations in E. coli isolates from diseased chickens in the Czech Republic, highlighting the presence of multidrug-resistant strains with resistance to β-lactams, quinolones, sulfonamides, and tetracyclines.
Antimicrobial Resistance, Virulence Genes, and Biofilm Formation Capacity Among Enterococcus species From Yaks in Aba Tibetan Autonomous Prefecture, China.
The study identified multiple antimicrobial resistance (AMR) genes in Enterococcus species isolated from yaks, including ermA, ermB, tetA, tetB, tetM, tetL, cat, optrA, and poxtA. These genes conferred resistance to various antibiotics such as erythromycin, tetracycline, chloramphenicol, and linezolid. Additionally, a high prevalence of multidrug-resistant (MDR) Enterococcus strains was observed.
Genomic analyses of multidrug-resistant Salmonella Indiana, Typhimurium, and Enteritidis isolates using MinION and MiSeq sequencing technologies.
The study identified various AMR genes in multidrug-resistant Salmonella isolates, including beta-lactamases (blaCTX-M-14, blaCTX-M-27, blaCTX-M-55, blaOXA-1, blaCMY-2, blaOXA, blaCMY), phenicol resistance genes (catB3, cmlA1, floR, catA1, catA2, oqxA, oqxB), aminoglycoside resistance genes (aac(6')-Ib-cr5, aac(6')-Ib-cr, oqxA2, qepA1, qnrS1), sulfonamide and trimethoprim resistance genes (sul1, sul2, sul3, dfrA12, dfrA7), and tetracycline resistance genes (tet(A), tet(B), tet(M)).
Molecular characteristics of fluoroquinolone-resistant avian pathogenic Escherichia coli isolated from broiler chickens.
The study identified several AMR genes and mutations in fluoroquinolone-resistant avian pathogenic Escherichia coli (APEC) isolates, including qnrA, qnrS, blaCTX-1, blaCTX-15, blaTEM-1, aac(3)-II, tetA, sul1, sul2, and catA1, along with mutations in gyrA and parC that confer fluoroquinolone resistance.
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
The study identified multiple AMR genes, including bla CTX-M-55, bla CMY-2, bla CTX-M-1, bla SHV-12, sul2, aac(3)-Ia, aadA, strA, strB, tet(A), tet(B), dfrA14, floR, cmlA1, catA1, catB3, qnrS1, qnrS2, qnrB19, mph(A), mph(B), arr-3, and aac(6')Ib-cr, in ESBL/pAmpC-producing E. coli isolates from broiler production.
Antibiotic Resistance Patterns of Pseudomonas spp. Isolated From Raw Milk Revealed by Whole Genome Sequencing.
The study identified various AMR genes and mutations in Pseudomonas spp. isolated from raw milk, highlighting the prevalence of multidrug-resistant strains and the presence of resistance determinants such as beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps.
Phage-Antibiotic Synergy Is Driven by a Unique Combination of Antibacterial Mechanism of Action and Stoichiometry.
The study identified the chloramphenicol acetyltransferase (Cat) and beta-lactamases (CTX-M-14 and CTX-M-14 A77V/D240G) as genes that confer resistance to chloramphenicol and ceftazidime, respectively, in Escherichia coli.
Occurrence and Antimicrobial Resistance Traits of Escherichia coli from Wild Birds and Rodents in Singapore.
F Plasmids Are the Major Carriers of Antibiotic Resistance Genes in Human-Associated Commensal Escherichia coli.
The study identifies various antibiotic resistance genes in commensal E. coli isolates, highlighting the prevalence of resistance genes on F plasmids and the role of mobile genetic elements in their dissemination.
Scarless Removal of Large Resistance Island AbaR Results in Antibiotic Susceptibility and Increased Natural Transformability in Acinetobacter baumannii.
The study shows that removing the AbaR resistance island from Acinetobacter baumannii restores antibiotic susceptibility and increases natural transformability. Several AMR genes within AbaR were identified, including aadB, aacC1, aphA1b, aacA, aadA1, strA, strB, blaVEB-1, blaOXA-10, sul1, dhfrI, dhfrX, tetA(A), tetA(G), cmlA1, cmlA5, cmlA9, catA1, arr-2, and sup.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2017/2018.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, focusing on Salmonella, Campylobacter, and E. coli. It notes high resistance levels to ampicillin, sulfonamides, and tetracyclines in Salmonella and E. coli isolates, along with rising resistance to fluoroquinolones in certain serovars. Carbapenemase-producing E. coli and Salmonella were rarely detected.
Outbreak of multi-drug-resistant (MDR) Shigella flexneri in northern Australia due to an endemic regional clone acquiring an IncFII plasmid.
The study identifies several AMR genes in a multi-drug-resistant Shigella flexneri strain, including bla DHA, bla OXA-1, tet(B), catA1, dfrA1, mph(A), ermB, qnrB, aadA, and qacEΔ1, which confer resistance to various antibiotics such as beta-lactams, tetracyclines, chloramphenicol, trimethoprim, macrolides, quinolones, aminoglycosides, and quaternary ammonium compounds.
Prediction of antimicrobial resistance in clinical Campylobacter jejuni isolates from whole-genome sequencing data.
The study identified seven resistance genes and several mutations associated with antimicrobial resistance in Campylobacter jejuni isolates, demonstrating the effectiveness of whole-genome sequencing in predicting resistance.
Genomic Analysis Reveals the Genetic Determinants Associated With Antibiotic Resistance in the Zoonotic Pathogen Campylobacter spp. Distributed Globally.
The study identified 15 acquired genes associated with resistance to five distinct antibiotic classes in Campylobacter spp., including novel beta-lactamase genes blaOXA-493 and blaOXA-576, and characterized mutations in gyrA, rpsL, and 23S rRNA that confer resistance to fluoroquinolones, streptomycin, and macrolides, respectively.
The New Klebsiellapneumoniae ST152 Variants with Hypermucoviscous Phenotype Isolated from Renal Transplant Recipients with Asymptomatic Bacteriuria-Genetic Characteristics by WGS.
The study identified several AMR genes in two hypermucoviscous Klebsiella pneumoniae isolates from renal transplant recipients, including bla CTX-M-15, aac(6')-Ib-cr, and others, indicating resistance to various antibiotics.
A Possible Role of Insertion Sequence IS1216V in Dissemination of Multidrug-Resistant Elements MES(PM1) and MES(6272-2) between Enterococcus and ST59 Staphylococcus aureus.
The study identifies the role of insertion sequence IS1216V in the dissemination of multidrug-resistant elements MES(PM1) and MES(6272-2) between Enterococcus and ST59 Staphylococcus aureus, highlighting the contribution of IS1216V in mediating the transfer of resistance genes such as ermB, aph(3')-IIIa, aadE, aacA-aphD, and cat.
Analysis of existence of multidrug-resistant H58 gene in Salmonella enterica serovar Typhi isolated from typhoid fever patients in Makassar, Indonesia.
Pathotyping and Antibiotic Resistance Profiling of Escherichia coli Isolates from Children with Acute Diarrhea in Amatole District Municipality of Eastern Cape, South Africa.
The study identified high levels of antibiotic resistance in E. coli isolates from children with acute diarrhea, particularly to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, and tetracycline. The resistance genes catA1 and tetA were found in 94% and 89% of the isolates, respectively.
Genomic epidemiology of Escherichia coli isolates from a tertiary referral center in Lilongwe, Malawi.
The study identifies the blaCTX-M-15 gene as a major contributor to cephalosporin resistance in Escherichia coli isolates from Malawi, along with other AMR genes such as aac(3)-IIa, aac(3)-IId, aadA5, ant(3'')-Ih, aph(3'')-Ib, aph(3')-Ia, aph(6)-Id, strA, strB, acrF, emrD, mdtM, blaTEM-1, catA1, catB3, dfrA17, sul2, mph(A), and tet(A).
Isolation and molecular characterization of multidrug-resistant Escherichia coli from chicken meat.
The study identified multiple antibiotic resistance genes in multidrug-resistant E. coli isolates from chicken meat, including tetA, sul1, aadA1, ereA, aac-3-IV, cmlA, catA1, SHV, and CITM, highlighting the prevalence of resistance to various antibiotics such as tetracycline, sulfonamide, streptomycin, erythromycin, gentamicin, chloramphenicol, and beta-lactams.
Fitness benefits to bacteria of carrying prophages and prophage-encoded antibiotic-resistance genes peak in different environments.
The study identified that prophage-encoded antibiotic-resistance genes (ARGs) such as bla (ampicillin resistance), cat (chloramphenicol resistance), and neo (kanamycin resistance) confer resistance in Escherichia coli. The benefits of these ARGs and prophages vary depending on environmental conditions, with ARGs being more beneficial under antibiotic exposure and prophages being more beneficial when the lytic lifecycle is induced.
Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae Complex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid.
The study identifies the blaCTX-M-1 gene carried on an IncI1/ST3 plasmid in Enterobacter cloacae and Escherichia coli isolates from humans and wild animals in Guadeloupe, highlighting the dissemination of this resistance determinant in the environment.
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing.
The study identified various AMR genes in E. coli isolates from bloodstream infections, including genes conferring resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, and trimethoprim. Additionally, mutations in quinolone resistance-determining regions of gyrA, parC, and parE were associated with ciprofloxacin resistance.
Antimicrobial resistance and gene regulation in Enteroaggregative Escherichia coli from Egyptian children with diarrhoea: Similarities and differences.
The study identified multiple antibiotic resistance genes in Enteroaggregative Escherichia coli (EAEC) isolates from Egyptian children with diarrhea, including bla CTX-M-14b, bla CTX-M-15, bla TEM-1B, aadA1, aph (3')-Ib, aph (3')-Ia, aph (6)-Id, dfrA1, mdfA, sul2, and tetA, which contribute to multidrug resistance.
Colistin-resistant Enterobacter kobei carrying mcr-9.1 and bla(CTX-M-15) infecting a critically endangered franciscana dolphin (Pontoporia blainvillei), Brazil.
The study reports the emergence of the mcr-9.1 gene in a colistin-resistant Enterobacter kobei strain isolated from a critically endangered franciscana dolphin in Brazil, along with various other AMR genes.
Colistin Dependence in Extensively Drug-Resistant Acinetobacter baumannii Strain Is Associated with ISAjo2 and ISAba13 Insertions and Multiple Cellular Responses.
The study identifies the disruption of lpxA, mlaD, and pldA genes by IS Ajo2 and IS Aba13 insertions in colistin-dependent A. baumannii, leading to lipid A deficiency and colistin dependence.
Characterization of Enterococci- and ESBL-Producing Escherichia coli Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified several AMR genes in Enterococcus and ESBL-producing E. coli isolates from bovine mastitis cases in Egypt, including erm(B), tetL, aac-aphD, vanA, and vanB.
Genomic Analysis of Antimicrobial Resistance and Resistance Plasmids in Salmonella Serovars from Poultry in Nigeria.
The study identified various antimicrobial resistance genes in Salmonella isolates from Nigerian poultry, including aac(6')-Ia, aac(6')-Ib, aadA7, aph(3")-Ia, aph(3")-Ib, aph(6')-Id, aph(6')-Ic, aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-IIa, aac(3)-Id, sul1, sul2, sul3, tet(A), tet(M), qnrS1, qnrB19, blaTEM, dfrA14, dfrA15, dfrA17, catA1, cmlA1, and floR. Mutations in gyrA (Ser83Phe, Asp87Tyr) and parC (Thr57Ser, Ser80Ile) were also associated with resistance to nalidixic acid and ciprofloxacin.
Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya.
The study identified several AMR genes in Salmonella isolates from Kenya, including blaTEM-1, aadA1, strA, strB, catA1, dhfr1, sul1, and sul2, which confer resistance to various antibiotics such as penicillins, cephalosporins, streptomycin, chloramphenicol, trimethoprim, and sulfonamides.
Endophytic Lifestyle of Global Clones of Extended-Spectrum β-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?
The study identifies multiple AMR genes in endophytic ESBL-producing Enterobacterales isolated from fresh vegetables, highlighting their potential role in the spread of antibiotic resistance.
Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya.
The study identified various carbapenemase genes (blaNDM-1, blaNDM-5, blaVIM-1, blaVIM-6, blaOXA-23, blaOXA-58, blaOXA-66, blaOXA-69, blaOXA-91, blaOXA-181, blaOXA-50) and other resistance genes (such as armA, rmtC, rmtF, aac(3)-I, aadA1, aph(3')-Ia, aph(3')-VI, aph(3')-Via, aph(6')-Id, mphE, msrE, mphA, ereA, dfrA1, dfrA12, dfrA14, dfrA17, dfrA20, sul1, sul2, tetB, tetD, tetG, tet39, qnrVC1, qnrS1, qnrB4, floR, catA1, catA2, catB3, catB7, cmlA1, cmlA5, arr-3, arr-2, sat2, acrF, mdtM, emrD, mexA, mexE, mexX, kdeA, oxa-10, oxa-395, oxa-396, oxa-846, adc-25, dha-1, act-16, cmY, ctx-m-15, shv-67, tem-1b) in carbapenem non-susceptible clinical isolates of gram-negative bacteria in Kenya, highlighting the diversity and prevalence of multidrug resistance.
Impact of Probiotic B. infantis EVC001 Feeding in Premature Infants on the Gut Microbiome, Nosocomially Acquired Antibiotic Resistance, and Enteric Inflammation.
Feeding B. infantis EVC001 to preterm infants reduced the abundance of antibiotic resistance genes (ARGs) and associated taxa, including cat, mphA, and mrx, which confer resistance to phenicol and macrolides.
Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era.
The study identifies several antimicrobial resistance genes in old Enterococcus faecalis isolates, including tet(L), cat, erm(B), aac(6')-aph(2''), aadD, drfC, and ble, demonstrating the early emergence of antimicrobial resistance traits in this species.
Genomic Background and Phylogeny of cfiA-Positive Bacteroides fragilis Strains Resistant to Meropenem-EDTA.
The study identifies two new metallo-beta-lactamase genes, cfiA14b and cfiA28, in Bacteroides fragilis strains resistant to meropenem-EDTA. Additionally, various other AMR genes such as aadS, aac(3'), ermF, lnu(AN2), vatA, mef(En2), tetX, tetQ, cat, bexA, bexB, qacE, cusR, mexAB-oprM, mexJK-oprM, mexXY-oprM, acrEF-tolC, and mdtEF-tolC were characterized.
Clonal Clusters, Molecular Resistance Mechanisms and Virulence Factors of Gram-Negative Bacteria Isolated from Chronic Wounds in Ghana.
The study identified various AMR genes and mutations in Gram-negative bacteria isolated from chronic wounds in Ghana, including beta-lactamases, fosfomycin resistance genes, chloramphenicol resistance genes, aminoglycoside resistance genes, fluoroquinolone resistance genes, tetracycline resistance genes, sulfonamide resistance genes, trimethoprim resistance genes, and efflux pumps. Mutations in gyrA, parE, and parC were also found to contribute to fluoroquinolone resistance.
Molecular Characterization of Enterococcus Isolates From Different Sources in Estonia Reveals Potential Transmission of Resistance Genes Among Different Reservoirs.
The study identified vanB genes in two vancomycin-resistant E. faecalis isolates and characterized various tetracycline, macrolide, lincosamide, and aminoglycoside resistance genes in E. faecalis and E. faecium isolates from different sources in Estonia.
Genomic Diversity and Virulence Potential of ESBL- and AmpC-β-Lactamase-Producing Escherichia coli Strains From Healthy Food Animals Across Europe.
The study identifies various ESBL and AmpC beta-lactamase genes, including bla SHV-12, bla CTX-M-1, bla CTX-M-2, bla CTX-M-14, bla CTX-M-15, bla TEM-52, and bla CMY-2, along with the mcr-1 gene conferring colistin resistance in E. coli isolates from food animals in Europe.
Two Acinetobacter baumannii Isolates Obtained From a Fatal Necrotizing Fasciitis Infection Display Distinct Genomic and Phenotypic Characteristics in Comparison to Type Strains.
The study characterizes two XDR Acinetobacter baumannii isolates, NFAb-1 and NFAb-2, obtained from a fatal necrotizing fasciitis case. These isolates exhibit resistance to multiple antibiotics, including carbapenems, aminoglycosides, fluoroquinolones, and others, indicating the presence of various AMR genes such as blaOXA-51-like, blaOXA-23-like, blaOXA-58-like, blaADC, blaNDM, blaKPC, aac(6')-Ib, aadA, ant(3'')-Ia, mph(A), erm(B), tet(A), tet(G), qnrS1, mexAB-oprM, acrAB-tolC, oqxAB, cat, cfr, and optrA.
A Real-Time Thermal Sensor System for Quantifying the Inhibitory Effect of Antimicrobial Peptides on Bacterial Adhesion and Biofilm Formation.
The study identified several AMR genes in E. coli and S. aureus isolates, including beta-lactamases (blaOXA-1, blaTEM-1A), chloramphenicol acetyltransferase (catA1), trimethoprim resistance gene (dfrA1), fluoroquinolone resistance gene (floR), sulfonamide resistance genes (sul1, sul2), methicillin resistance gene (mecA), beta-lactamase (blaZ-like), and tetracycline efflux pumps (tet(K), tet(M)).
Comparative Characteristics and Zoonotic Potential of Avian Pathogenic Escherichia coli (APEC) Isolates from Chicken and Duck in South Korea.
The study identified several antimicrobial resistance genes in APEC isolates from chickens and ducks in South Korea, including mcr-1, blaTEM, blaCTX-M group I, blaCTX-M group IV, mphA, cat, floR, cmlA, strA-B, aadA, sul1, sul2, tetA, and tetB. These genes conferred resistance to various antibiotics such as colistin, ampicillin, azithromycin, chloramphenicol, streptomycin, sulfisoxazole, and tetracycline. The study also highlighted the zoonotic potential of certain APEC isolates, particularly those belonging to phylogenetic group B2.
Staphylococcus epidermidis Phages Transduce Antimicrobial Resistance Plasmids and Mobilize Chromosomal Islands.
The study identifies several antimicrobial resistance genes, including aad(6), tetK, bla, erm, and cat, which confer resistance to streptomycin, tetracycline, chloramphenicol, and erythromycin. These genes were transferred via phage-mediated transduction in Staphylococcus epidermidis.
Circulation of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli of Pandemic Sequence Types 131, 648, and 410 Among Hospitalized Patients, Caregivers, and the Community in Rwanda.
The study identifies the circulation of pandemic sequence types ST131, ST648, and ST410 of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in Rwanda, highlighting their multidrug resistance and potential for transmission among patients, caregivers, and the community.
Molecular Characterization of Multidrug-Resistant Yersinia enterocolitica From Foodborne Outbreaks in Sweden.
The study identified a chromosomally encoded multidrug-resistance cassette carrying resistance genes against chloramphenicol (catA1), streptomycin (aadA1), sulfonamides (sul1), and a mercury resistance module, as well as a 5.7-kbp plasmid with tetB encoding an ABC transporter in Yersinia enterocolitica strains from a foodborne outbreak in Sweden.
Diversity of Plasmids and Genes Encoding Resistance to Extended-Spectrum β-Lactamase in Escherichia coli from Different Animal Sources.
The study identified various AMR genes and mutations in E. coli isolates from different animal sources, highlighting the presence of ESBL genes such as bla CTX-M-15, bla TEM-1B, and bla CMY-28, as well as mutations in parC and gyrA that confer resistance to fluoroquinolones.
Clonal dissemination of Salmonella enterica serovar albany with concurrent resistance to ampicillin, chloramphenicol, streptomycin, sulfisoxazole, tetracycline, and nalidixic acid in broiler chicken in Korea.
The study identified multiple AMR genes in Salmonella enterica serovar Albany, including ampC, str, tet, sul, nal, and cat, which confer resistance to various antibiotics such as ampicillin, streptomycin, tetracycline, sulfisoxazole, nalidixic acid, and chloramphenicol. These findings highlight the multidrug-resistant nature of S. Albany isolates in Korean broiler chickens.
Whole-Genome Sequencing and Machine Learning Analysis of Staphylococcus aureus from Multiple Heterogeneous Sources in China Reveals Common Genetic Traits of Antimicrobial Resistance.
The study identifies multiple AMR genes in Staphylococcus aureus isolates from various sources in China, including mecA, cat, aacA-aphD, ugpQ, maoC, and tcaA, which are associated with resistance to oxacillin, cefoxitin, chloramphenicol, gentamicin, and trimethoprim-sulfamethoxazole.
Subtypes, resistance and virulence platforms in extended-drug resistant Acinetobacter baumannii Romanian isolates.
The study identifies several AMR genes including bla OXA-23, bla OXA-24, bla OXA-51, and various aminoglycoside, sulfonamide, tetracycline, and macrolide resistance genes in XDR A. baumannii isolates from Romania.
Outbreak of NDM-1-producing Klebsiella pneumoniae in the intensive care unit during the COVID-19 pandemic: Another nightmare.
The study reports an outbreak of NDM-1-producing Klebsiella pneumoniae in an ICU during the COVID-19 pandemic, highlighting the presence of multiple AMR genes including blaNDM-1, blaTEM-1, blaCTX-M-15, blaOXA-1, blaCMY-4, and others, along with mutations in ParC and GyrA contributing to quinolone resistance.
Foodborne Pathogenic Vibrios: Antimicrobial Resistance.
The paper discusses the presence of various antibiotic resistance genes in Vibrio species, including strB, sul2, tetA, blaTEM, qnrA, ermB, floR, aac(3)-IIa, blaNDM-1, blaCMY, blaP1, catB3, and others, which confer resistance to antibiotics such as streptomycin, sulfamethoxazole, tetracycline, ampicillin, fluoroquinolones, erythromycin, florfenicol, gentamicin, carbapenems, chloramphenicol, and trimethoprim.
The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries.
The study identified multiple AMR genes and mutations in invasive non-typhoidal Salmonella isolates from sub-Saharan Africa, highlighting the prevalence of multidrug resistance.
Phylogenomics and antimicrobial resistance of Salmonella Typhi and Paratyphi A, B and C in England, 2016-2019.
The study identifies multiple AMR genes and mutations in Salmonella Typhi and Paratyphi A, B, and C, highlighting increasing resistance to fluoroquinolones, beta-lactams, sulfonamides, and trimethoprim. Notable findings include the emergence of XDR strains and the detection of novel resistance mechanisms.
Two carbapenem-resistant ST1:ST231:KL1:OCL1 Acinetobacter baumannii strains recovered in Tehran, Iran, carry AbaR31 in the chromosome and AbaR4 and TnaphA6 in a RepAci6 plasmid.
The study identifies multiple antibiotic resistance genes, including catA1, tetA(A), sul1, aacC1, aadA1, aphA6, and oxa23, in two carbapenem-resistant Acinetobacter baumannii strains, ABH008 and ABS200, highlighting their extensive drug resistance.
Machine Learning Prediction of Resistance to Subinhibitory Antimicrobial Concentrations from Escherichia coli Genomes.
The study identifies several known AMR genes, including aacA-aphD, cat, dhfrI, dhfrV, neo, tetA, and tnpA, which are associated with resistance to kanamycin, chloramphenicol, trimethoprim, and ceftriaxone. These genes were validated through machine learning predictions of growth under subinhibitory antimicrobial concentrations.
Acquisition and loss of CTX-M plasmids in Shigella species associated with MSM transmission in the UK.
The study identifies the presence of bla CTX-M-27, erm(B), mph(A), aph(3')-Ib, aph(6)-Id, sul2, and tet(A) in Shigella isolates associated with MSM transmission in the UK, highlighting the role of plasmids in the spread of antimicrobial resistance.
Occurrence of Colibacillosis in Broilers and Its Relationship With Avian Pathogenic Escherichia coli (APEC) Population Structure and Molecular Characteristics.
The study identified multiple antimicrobial resistance genes in Avian Pathogenic Escherichia coli (APEC) isolates, including beta-lactamases (blaCMY-2, blaSHV-12, blaTEM-52, blaCTX-M-1), aminoglycoside resistance genes (aac(3)-IV, aadA, strA, strB, aph(3')-Ib), sulfonamide resistance gene (sul1), tetracycline resistance genes (tet(A), tet(B)), trimethoprim resistance gene (dfrA), quinolone resistance genes (qnrS1, qnrS2, qnrB19), macrolide resistance genes (mph(A), mph(B)), and chloramphenicol resistance gene (catA1).
Genome Analysis of Acinetobacter lwoffii Strains Isolated from Permafrost Soils Aged from 15 Thousand to 1.8 Million Years Revealed Their Close Relationships with Present-Day Environmental and Clinical Isolates.
The study identified antibiotic resistance genes such as aadA27, cflA, tet(H), blaOXA-134, cat, macAB, and tolC in Acinetobacter lwoffii strains isolated from permafrost soils. These genes were found to be present in both clinical and environmental strains, suggesting a shared resistance profile.
Antimicrobial Resistance Patterns and Risk Factors Associated with Salmonella spp. Isolates from Poultry Farms in the East Coast of Peninsular Malaysia: A Cross-Sectional Study.
The study identified multiple antimicrobial resistance genes in Salmonella spp. isolates from poultry farms in Malaysia, including blaTEM, tet(A), tet(B), catA1, cat2, floR, sul1, and sul2, which confer resistance to beta-lactams, tetracyclines, chloramphenicol, and sulfonamides.
Population genetic structure, serotype distribution and antibiotic resistance of Streptococcus pneumoniae causing invasive disease in children in Argentina.
The study identified several AMR genes in Streptococcus pneumoniae isolates from Argentina, including ermB, mefA, tet(M), cat, folA, and folP, which confer resistance to erythromycin, tetracycline, chloramphenicol, and cotrimoxazole. These genes were validated through molecular characterization and WGS.
Insight Into Whole Genome of Aeromonas veronii Isolated From Freshwater Fish by Resistome Analysis Reveal Extensively Antibiotic Resistant Traits.
The study identified 17 AMR genes in Aeromonas veronii isolates from tilapia, highlighting extensive antibiotic resistance traits, including resistance to beta-lactams, aminoglycosides, tetracyclines, and others.
Genomic Analysis of Ciprofloxacin-Resistant Salmonella enterica Serovar Kentucky ST198 From Spanish Hospitals.
The study identified several AMR genes and mutations associated with ciprofloxacin resistance in Salmonella enterica serovar Kentucky ST198 isolates from Spanish hospitals. Key findings include the presence of blaTEM-1B, aacA5, aadA7, sul1, tet(A), catA1, and aac(6′)-Ib genes, along with mutations in gyrA (Ser83Phe) and parC (Thr57Ser, Ser80Ile).
Identification of Three Novel PmGRI1 Genomic Resistance Islands and One Multidrug Resistant Hybrid Structure of Tn7-like Transposon and PmGRI1 in Proteus mirabilis.
The study identifies three novel variants of PmGRI1 and a hybrid structure combining Tn7-like transposon and PmGRI1 in Proteus mirabilis, highlighting their role in carrying multiple antibiotic resistance genes.
Invasive atypical non-typhoidal Salmonella serovars in The Gambia.
The study identified several antimicrobial resistance genes in invasive Salmonella serovars in The Gambia, including blaTEM-1B, aph(3'')-Ib, aph(6)-Id, catA1, dfrA7, sul1, sul2, tet(B), and fosA7. These genes conferred resistance to various antibiotics such as ampicillin, penicillin, gentamicin, kanamycin, tobramycin, chloramphenicol, trimethoprim, sulfamethoxazole, tetracycline, and fluoroquinolones.
High Genomic Identity between Clinical and Environmental Strains of Herbaspirillum frisingense Suggests Pre-Adaptation to Different Hosts and Intrinsic Resistance to Multiple Drugs.
The study identified several antimicrobial resistance genes in Herbaspirillum frisingense clinical strain AU14559, including beta-lactamases and vanS/R genes involved in vancomycin resistance. These findings highlight the potential for multidrug resistance in this species.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
The study identified various CTX-M-type beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, bla CTX-M-55, and bla CTX-M-65, as well as other beta-lactamase genes such as bla TEM-1, bla CARB-2, and bla CMY-2 in ESBL E. coli isolates from sheep and their abattoir environment. Additional AMR genes related to aminoglycosides, macrolides, phenicols, quinolones, sulfonamides, tetracyclines, and trimethoprim were also detected.
Phage Cocktail Development against Aeromonas salmonicida subsp. salmonicida Strains Is Compromised by a Prophage.
The study identifies antibiotic resistance genes such as sul1, sul2, floR, tetA, and cat in Aeromonas salmonicida subsp. salmonicida strains, highlighting their role in resistance to sulfonamides, chloramphenicol, and tetracycline. It also shows that the presence of Prophage 3 reduces the effectiveness of phage cocktails against these strains.
High-Resolution Genomic Profiling of Carbapenem-Resistant Klebsiella pneumoniae Isolates: A Multicentric Retrospective Indian Study.
The study identifies various carbapenem resistance genes such as blaOXA232, blaNDM1, blaNDM5, blaOXA181, and others in Klebsiella pneumoniae isolates from India. It also characterizes mutations in ompK35 and ompK36 contributing to carbapenem resistance.
Occurrence and spread of antibiotic-resistant bacteria on animal farms and in their vicinity in Poland and Ukraine-review.
The review highlights the presence of antibiotic-resistant bacteria and resistance genes in the environments of animal farms in Poland and Ukraine, emphasizing the spread of multidrug-resistant strains such as MRSA and Salmonella. Key resistance genes identified include blaTEM, blaPSE, floR, tetA, tetB, tetC, tetG, cat1, dfrA1, dfrA5, dfrA7, dfrA12, dfrA17, sul1, sul2, sul3, ermB, tetL, tetW, tetM, blaZ, mecA, qnrS1, qnrS3, qnrB10, qnrB19, blaCTX-M-25, and blaOXA-21.
Soil Bacteria in Urban Community Gardens Have the Potential to Disseminate Antimicrobial Resistance Through Horizontal Gene Transfer.
The study identified various antimicrobial resistance genes (ARGs) in soil and vegetable bacteria from urban community gardens, highlighting the potential for horizontal gene transfer of resistance traits to clinically relevant pathogens.
Genomic comparisons of Escherichia coli ST131 from Australia.
The study identifies multiple AMR genes and mutations in Australian E. coli ST131 isolates, including bla CTX-M-15 and bla CTX-M-27 for beta-lactam resistance, aadA5, strA, strB, mphA, dfrA17, sul1, qacEΔ1, and chrA for resistance to aminoglycosides, macrolides, trimethoprim, sulfonamides, quaternary ammonium compounds, and chromate. Fluoroquinolone resistance mutations in gyrA and parC were also found.
S. algae as a reservoir and a vehicle of potential antimicrobial resistance
The study identified multiple antimicrobial resistance genes in S. algae strains, including genes conferring resistance to beta-lactams, aminoglycosides, quinolones, phenicols, macrolides, sulfonamides, tetracyclines, and lincosamides.
Signal Peptidase-Mediated Cleavage of the Anti-σ Factor RsiP at Site 1 Controls σ(P) Activation and β-Lactam Resistance in Bacillus thuringiensis.
The study identifies SipP as a signal peptidase responsible for cleaving RsiP at site 1, which is essential for σP activation and β-lactam resistance in Bacillus thuringiensis. Mutations in the signal peptidase cleavage site of RsiP (V82W, S84W, S84A) prevent SipP-mediated cleavage, blocking σP activation and β-lactam resistance.
Prevalence, Antimicrobial Resistance, and Whole Genome Sequencing Analysis of Shiga Toxin-Producing Escherichia coli (STEC) and Enteropathogenic Escherichia coli (EPEC) from Imported Foods in China during 2015-2021.
The study identified several antimicrobial resistance genes in STEC and EPEC isolates from imported foods in China, including blaTEM-1B, tetA, tetB, catA1, cmlA1, aadA1, aph(4)-Ia, aac(3)-IV, aph(6)-Id, aph(3")-Ib, sul3, dfrA12, and qnrS1, which conferred resistance to various antibiotics such as ampicillin, tetracycline, chloramphenicol, gentamicin, trimethoprim-sulfamethoxazole, and ciprofloxacin.
Population genomics of the food-borne pathogen Vibrio fluvialis reveals lineage associated pathogenicity-related genetic elements.
The study identified 21 antimicrobial resistance genes in Vibrio fluvialis, with 19 of them predominantly present in VflPop2. The tetracycline resistance gene tet(35) was found in 95% of VflPop2 strains, highlighting its significance in the population. Additionally, the plasmid pBD146 was associated with resistance to trimethoprim-sulfamethoxazole, and the presence of dfr6 gene in pBD146 was linked to this resistance.
Overcoming Multidrug Resistance in Salmonella spp. Isolates Obtained From the Swine Food Chain by Using Essential Oils: An in vitro Study.
The study identified several AMR genes in Salmonella isolates from the swine food chain, including parC, catA1, nfsB, nfsA, blaTEM, tetA, and tetB, which confer resistance to various antibiotics such as gentamicin, amikacin, tobramycin, chloramphenicol, ampicillin, piperacillin, and tetracycline.
River Biofilms Microbiome and Resistome Responses to Wastewater Treatment Plant Effluents Containing Antibiotics.
The study identified various antibiotic resistance genes (ARGs) in river biofilms upstream and downstream of a wastewater treatment plant (WWTP), including qnrA, qnrS, mfsA, ermC, ermX, macB, mefA_10, cat, catB3, aadB, aph(3')-III, AAC(3)-Ib, bacA_1, blaPer-1, blaIMP, blaTEM, blaKPC, blaDHA, cblA, ermC, ermY, ermX, mdtL, cusF, copD, qacA, mecA, dfrF, arnA, sul1, sulA, vat(A), IS6100, ISS1N, Intl1, blaCTX-M, blaIMP, mefA_10, tolC, mdfF, acrA, dfrA27, aac(6')-IIa, vanA, intl3, and TTV. These genes were associated with resistance to various antibiotics such as fluoroquinolones, macrolides, chloramphenicol, aminoglycosides, beta-lactams, polymyxins, sulfonamides, and others. The study also found that the resistome composition varied between upstream and downstream sites, indicating the impact of WWTP effluents on the distribution of ARGs in river biofilms.
Genomic characterisation of three GES-producing Enterobacterales isolated in the Czech Republic
Three GES-producing Enterobacterales isolates were characterized, including novel variants of blaGES and a new blaOXA-1011 gene associated with carbapenem resistance.
Conjugation-Based Genome Engineering in Deinococcus radiodurans.
The study reports the development of a conjugation-based DNA transfer method from E. coli to D. radiodurans, enabling the introduction of stable, replicating plasmids expressing antibiotic resistance markers. The cat gene was shown to confer chloramphenicol resistance in D. radiodurans.
Genomic characterization of multidrug-resistant Salmonella serovar Kentucky ST198 isolated in poultry flocks in Spain (2011-2017).
The study identified multiple antimicrobial resistance genes in multidrug-resistant Salmonella serovar Kentucky ST198 isolates from Spain, including genes conferring resistance to aminoglycosides, beta-lactams, sulfonamides, tetracyclines, trimethoprim, and colistin.
Establishment of Epidemiological Cut-Off Values and the Distribution of Resistance Genes in Aeromonas hydrophila and Aeromonas veronii Isolated from Aquatic Animals.
The study identified several tetracycline resistance genes (tetA, tetB, tetD, tetE), florfenicol resistance gene (floR), chloramphenicol resistance gene (cat), quinolone resistance gene (qnrS), and aminoglycoside resistance genes (aac(6')-1b, strA-strB) in Aeromonas hydrophila and Aeromonas veronii isolates from aquatic animals.
Antimicrobial Resistance, Biofilm Formation, and Virulence Genes in Enterococcus Species from Small Backyard Chicken Flocks.
The study identified several antimicrobial resistance (AMR) genes in Enterococcus species isolated from backyard chickens, including ermB, ermA, tetM, tetL, vanA, cat, and pbp5. These genes were associated with resistance to erythromycin, tetracycline, vancomycin, chloramphenicol, and ampicillin.
Invited Review: Antimicrobial Use and Antimicrobial Resistance in Pathogens Associated with Diarrhea and Pneumonia in Dairy Calves.
The review identified several AMR genes in pathogens associated with calf diarrhea and pneumonia, including beta-lactamases (blaCMY, blaCTX-M, blaTEM), tetracycline resistance genes (tetA, tetB, tetM, tetO), aminoglycoside resistance genes (strA, strB, aadA), sulfonamide resistance genes (sul1, sul2), phenicol resistance genes (cat, floR), and macrolide/lincosamide resistance genes (cfr, ermB).
Use of genomics to explore AMR persistence in an outdoor pig farm with low antimicrobial usage.
The study identified various AMR genes in E. coli isolates from a low antimicrobial usage pig farm, highlighting the persistence of multidrug-resistant strains despite minimal selective pressure.
Using whole-genome sequence data to examine the epidemiology of antimicrobial resistance in Escherichia coli from wild meso-mammals and environmental sources on swine farms, conservation areas, and the Grand River watershed in southern Ontario, Canada.
The study identified several AMR genes in E. coli isolates from wild meso-mammals and environmental sources, including blaTEM-1, tet(A), tet(B), sul1, sul2, aph(3”)-Ib, aph(6)-Id, blaCMY-2, qnrS1, and floR. These genes conferred resistance to various antibiotics such as beta-lactams, tetracyclines, sulfonamides, aminoglycosides, and quinolones.
Identifying the Sources of Intestinal Colonization With Extended-Spectrum β-Lactamase-Producing Escherichia coli in Healthy Infants in the Community.
The study identifies several AMR genes, including blaCTX-M-15, qnrS1, ermB, aadA1, aph(3')-Ib, aph(6)-Id, dfrA1, catA1, aadA2, dfrA5, dfrA12, qnrS13, aac(6')-Ib-cr5, blaTEM-1, blaOXA-1, sul1, and dfrA17, associated with ESBL-Ec in children, mothers, and drinking water in rural Bangladesh.
History-dependent physiological adaptation to lethal genetic modification under antibiotic exposure.
The study demonstrates that Escherichia coli cells can physiologically adapt to the deletion of the chloramphenicol resistance gene (mcherry-cat) under continuous chloramphenicol exposure, leading to growth restoration without additional mutations.
Molecular diagnostics and next-generation sequencing reveal real etiological characteristics of invasive Salmonella infection in febrile illness in Freetown, Sierra Leone.
The study identified several antimicrobial resistance genes in a Salmonella Typhi isolate, including aac(6')-Iaa, catA1, dfrA15, and sul1, indicating resistance to aminoglycosides, phenicols, trimethoprim, and sulfonamides.
Characterization of qnrB-carrying plasmids from ESBL- and non-ESBL-producing Escherichia coli.
The study characterized qnrB-carrying plasmids from ESBL- and non-ESBL-producing E. coli, identifying qnrB1, qnrB2, and qnrB19 as major quinolone resistance determinants. These plasmids were found to be self-transmissible and associated with various resistance genes.
Antimicrobial susceptibility and genomic profiling of Salmonella enterica from bloodstream infections at a tertiary referral hospital in Lusaka, Zambia, 2018-2019.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella enterica isolates, including blaTEM-1B, catA1, sul2, sul1, dfrA7, dfrA14, and mutations in gyrA, gyrB, and parC. These resistance mechanisms contribute to multidrug resistance and emerging resistance to ciprofloxacin and cephalosporins.
Genetic background of Cambodian pneumococcal carriage isolates following pneumococcal conjugate vaccine 13.
The study identified multiple antimicrobial resistance (AMR) genes in Cambodian pneumococcal carriage isolates, including ermB, mefA, cat, tet(M), tet(O), folA, and folP, which confer resistance to erythromycin, chloramphenicol, tetracycline, trimethoprim, and sulfamethoxazole. These genes were validated through predictive resistance profiling using the CDC-AMR pipeline.
Molecular Mechanisms of Drug Resistance in Staphylococcus aureus.
The paper discusses the molecular mechanisms of drug resistance in Staphylococcus aureus, focusing on beta-lactam, glycopeptide, oxazolidinone, MLS-B, aminoglycoside, and other resistance mechanisms. Key genes identified include blaZ, mecA, mecC, vanA, cfr, ermA, ermC, aac(6')-Ib, aph(3')-IIIa, and aadD. Mutations in pbp2 and pbp2a were also found to contribute to resistance.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
High Prevalence of Beta-Lactam-Resistant Escherichia coli in South Australian Grey-Headed Flying Fox Pups (Pteropus poliocephalus).
The study identified various beta-lactam-resistant Escherichia coli strains in South Australian grey-headed flying fox pups, including resistance genes such as blaTEM-1B, blaTEM-1C, blaTEM-33, blaCMY-2, dfrA17, aadA5, dfrA5, sul2, tet(A), tet(B), and catA1.
Genomic characterization of invasive typhoidal and non-typhoidal Salmonella in southwestern Nigeria.
The study identified multiple antibiotic resistance genes and mutations in invasive Salmonella isolates from Nigeria, highlighting the prevalence of multidrug-resistant S. Typhi 3.1.1 and other serovars carrying resistance determinants such as blaTEM-1, aph(3')-Ib, catA1, dfrA14, sul2, tetA, and qnrB19.
Prevalence and distribution of extended-spectrum β-lactamase and AmpC-producing Escherichia coli in two New Zealand dairy farm environments.
The study identified bla CMY-2, bla CTX-M-1, bla CTX-M-15, and bla OXA-1 genes in ESBL- and AmpC-producing E. coli isolates from New Zealand dairy farms, highlighting the presence of plasmid-mediated resistance mechanisms.
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria.
The study identified several AMR genes in multi-drug resistant E. coli isolates, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-65, bla OXA-1, bla OXA-2, bla CMY-2, bla NDM-1, bla NDM-5, aac(3)-IId, aac(3)-IIe, aac(6')-Ib-cr, aad A5, ant(2′′)-Ia, aph(3′′)-Ib, aph(3′′)-VI, aph(6)-Id, ermB, ermD, fosA3, fosA7, mdtM, emrD, sul1, sul2, sul3, tetA, tetB, tetM, dfrA1, dfrA7, dfrA8, dfrA12, dfrA14, dfrA17, dfrA82, dfrB4, qepA, qepA1, qepA2, qepA4, qnrB19, qnrS1, qacE, catA1, catA2, catB3, cmlA1, mphA.
Whole-Genome Analysis of Staphylococcus aureus Isolates from Ready-to-Eat Food in Russia.
The study identified multiple antimicrobial resistance (AMR) genes in Staphylococcus aureus isolates from ready-to-eat food in Russia, including blaZ, mecA, inuA, cat, ermC, dfrG, dfrK, aaC, aaD, ant(9)-Ia, tet(K), tet(cluster), erm(A), erm(C), cat(pC194), and fexA. These genes conferred resistance to various antibiotics such as penicillins, lincosamides, phenicols, macrolides, aminoglycosides, tetracyclines, and fluoroquinolones.
Occurrence of Antimicrobial-Resistant Escherichia coli in Marine Mammals of the North and Baltic Seas: Sentinels for Human Health.
The study identified antimicrobial-resistant Escherichia coli in marine mammals from the North and Baltic Seas, highlighting the presence of resistance genes such as blaTEM, strA, strB, aadA1, sul1, sul2, tet(A), tet(B), tet(D), qnrS, floR, catA1, blaOXA-1-like, blaSHV, and blaCMY-2.
Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Strains Recovered from Chilean Hospitals Reveals Lineages Specific to South America and Multiple Routes for Acquisition of Antibiotic Resistance Genes.
The study identifies various AMR genes in carbapenem-resistant Acinetobacter baumannii strains from Chile, including blaTEM, aacC2, aphA6, sul1, sul2, catA1, tetA(A), aadA1, dfrA1, strAB, cmlB1, floR, oxa58, and oxa23, highlighting the diversity of resistance mechanisms and the role of mobile genetic elements in their dissemination.
Antibiotic resistance in plant growth promoting bacteria: A comprehensive review and future perspectives to mitigate potential gene invasion risks.
This review highlights the prevalence of antibiotic resistance genes (ARGs) in plant growth-promoting bacteria (PGPB) and emphasizes the potential risks of ARG dissemination through biofertilizers. Key findings include the identification of various ARGs such as bacA, fosB, ermD, bl2a, vanSA, cat, acrD, mexF, mexD, mexW, mexE, mexY, mexX, mexZ, mexR, mexA, mexB, mexC, mexD, mexE, and mexF, which confer resistance to multiple antibiotics.
Comparative genomics analysis of the multidrug-resistant Aeromonas hydrophila MX16A providing insights into antibiotic resistance genes.
The study identified multiple antibiotic resistance genes in Aeromonas hydrophila MX16A, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline efflux pumps, and quinolone resistance determinants, contributing to its multidrug-resistant phenotype.
Distribution Patterns of Antibiotic Resistance Genes and Their Bacterial Hosts in a Manure Lagoon of a Large-Scale Swine Finishing Facility.
The study identified multiple antibiotic resistance genes (ARGs) in manure samples from a swine finishing facility, highlighting the prevalence of resistance to tetracyclines, macrolides, aminoglycosides, and other antibiotics. Key genes included tet(M), lnuA, erm(35), aadS, mphB, dfrG, vga-type ABC-F, lsa-type ABC-F, msr-type ABC-F, optrA, and others, primarily found in Firmicutes, Proteobacteria, and Bacteroidota. These genes were associated with resistance mechanisms such as target alteration, antibiotic inactivation, and efflux pumps.
The hazard of carbapenemase (OXA-181)-producing Escherichia coli spreading in pig and veal calf holdings in Italy in the genomics era: Risk of spill over and spill back between humans and animals.
The study identifies multiple AMR genes, including bla OXA-181, bla TEM-1B, aac (3)-IId, aad A2, cml A1, dfr A12, mef (B), sul 3, tet (A), tet (M), incX3, incX1, incFII, qnr S1, aph (3″)-Ib, aph (6)-Id, flo R, lnu (F), sul 2, sul 3, tet (B), mph (A), mph (G), qnr B4, rmt B, and fos A3, in OXA-181-producing E. coli isolates from pigs and bovines in Italy. These genes confer resistance to various antibiotics, including carbapenems, cephalosporins, penicillins, aminoglycosides, trimethoprim, macrolides, sulfonamides, tetracyclines, fluoroquinolones, and fosfomycin.
Whole-Genome and Plasmid Comparative Analysis of Campylobacter jejuni from Human Patients in Toyama, Japan, from 2015 to 2019.
The study identified tetracycline resistance gene tet(O), aminoglycoside resistance genes ant(6)-Ia and aph(3')-III, and chloramphenicol resistance gene cat in Campylobacter jejuni isolates from Toyama, Japan. Additionally, blaOXA-184 was found in ampicillin-resistant isolates.
Isolation, Identification and Genetic Characterization of Antibiotic Resistant Escherichia coli from Frozen Chicken Meat Obtained from Supermarkets at Dhaka City in Bangladesh.
The study identified several antimicrobial resistance genes in E. coli isolates from frozen chicken meat, including tet(A), tet(B), aadA1, aac(3)-IV, ereA, blaCITM, blaSHV, sulI, catA1, and cmlA, which confer resistance to tetracycline, streptomycin, gentamicin, erythromycin, ampicillin, sulfonamide, and chloramphenicol.
Conjugation of plasmid harboring bla (NDM-1) in a clinical Providencia rettgeri strain through the formation of a fusion plasmid.
The study identifies multiple AMR genes, including blaNDM-1, blaOXA-10, blaPER-4, aph(3')-VI, ant(2'')-Ia, ant(3')-Ia, sul1, catB8, catA1, mph(E), and tet, in a multidrug-resistant Providencia rettgeri strain. These genes contribute to resistance against various antibiotics, including carbapenems, beta-lactams, aminoglycosides, sulfonamides, chloramphenicol, macrolides, and tetracyclines.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Molecular characterization of Arcobacter butzleri isolates from poultry in rural Ghana.
The study identified several antimicrobial resistance genes in Arcobacter butzleri isolates from poultry in Ghana, including blaOXA-464, tetM, ermB, and others, highlighting the presence of multidrug-resistant strains and the potential for horizontal and vertical transmission of resistance genes.
In silico analyses of diversity and dissemination of antimicrobial resistance genes and mobile genetics elements, for plasmids of enteric pathogens.
The study identifies a diverse array of antimicrobial resistance (AMR) genes across various plasmid replicon types in enteric pathogens, highlighting the prevalence of resistance genes in plasmids such as IncHI2, IncN, IncA/C, IncP, IncHI1, and IncFIA. Key AMR genes include aac(3)-IId, aac(3)-IIg, aac(6')-Ib3, aadA1, aadA5, aph(3'')-Ib, bla CMY-2, bla CTX-M-27, bla NDM-1, mcr-9.1, and others, which confer resistance to antibiotics such as gentamicin, cephalosporins, carbapenems, colistin, and tetracycline.
Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteria.
The study identified several acquired and intrinsic antimicrobial resistance genes in lactic acid bacteria and bifidobacteria, including tetW, ANT(6)-Ia, aac(6')-Ie-APH(2'')-Ia, erm(B), erm(49), cat, dfrG, arr-4, and fosXCC. Additionally, mutations in S12, rsmG, Lsa(A), MsrC, and PBP5 were associated with resistance to various antibiotics.
Silver nanoparticles enhance the efficacy of aminoglycosides against antibiotic-resistant bacteria.
The study identifies several AMR genes, including mcr-1, mcr-3, mcr-4, aadA5, catA1, bla CMY-2, bla CTX-M-55, dfrA17, fosA, mph(A), rmtB, strA, strB, sul1, sul2, bla TEM-1B, and bla CMY-48, which confer resistance to various antibiotics in different bacterial strains.
An optogenetic toolkit for light-inducible antibiotic resistance.
The study presents an optogenetic toolkit enabling light-inducible antibiotic resistance in Escherichia coli, utilizing genes such as bla, knt, cat, and tetA, which confer resistance to carbenicillin, kanamycin, chloramphenicol, and tetracycline, respectively.
Metagenomic analysis reveals patterns and hosts of antibiotic resistance in different pig farms.
The study identified various antibiotic resistance genes (ARGs) in pig manure samples from different regions of Shanxi, China, highlighting the prevalence of tetracycline, aminoglycoside, macrolide, and phenicol resistance genes. Key ARGs included tet(W), tet(40), tet(Q), erm(B), erm(F), mef(A), aph(3')-III, ant(6)-Ia, cfr(C), floR, blaACI-1, optrA, cat, cfxA4, cfxA5, blaCTX-M-105, blaCTX-M-65, fexB, erm(T), mdf(A), and ole(B).
Genetic Organization of Acquired Antimicrobial Resistance Genes and Detection of Resistance-Mediating Mutations in a Gallibacterium anatis Isolate from a Calf Suffering from a Respiratory Tract Infection.
The study identified multiple acquired antimicrobial resistance genes and resistance-mediating mutations in a Gallibacterium anatis isolate from a calf with a respiratory tract infection, highlighting the potential for this bacterium to serve as a reservoir for antimicrobial resistance genes.
Antimicrobial resistance in Campylobacter fetus: emergence and genomic evolution.
The study identified several AMR genes and mutations in Campylobacter fetus, including ant(6)-Ib, aph(3')-III, tet(O), tet(44), and cat, which confer resistance to various antibiotics. Mutations in the gyrA gene were also found to contribute to fluoroquinolone resistance.
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.
The study identified various AMR genes in sepsis-causing bacteria, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others, highlighting the complexity of AMR in these pathogens.
Analysis of Antimicrobial Resistance Genes (ARGs) in Enterobacterales and A. baumannii Clinical Strains Colonizing a Single Italian Patient.
The study identified various antimicrobial resistance genes in Enterobacterales and A. baumannii clinical strains from a single patient, highlighting the presence of blaNDM-1, qnrS1, aadA1, strA-strB, sul2, tet(J), catA1, blaACT-15, blaTEM-1B, dfrA14, oqxB, fosA, blaLEN-22, blaOXA-23, blaADC-25, blaOXA-66, armA, mph(E), msr(E), and tetB, indicating multidrug resistance and potential for horizontal gene transfer.
Genomic Diversity, Antimicrobial Susceptibility, and Biofilm Formation of Clinical Acinetobacter baumannii Isolates from Horses.
The study identified multiple AMR genes in equine Acinetobacter baumannii isolates, including beta-lactamases (bla OXA-51-like, bla ADC-25, bla TEM-1D), sulfonamide resistance genes (sul1, sul2), chloramphenicol resistance genes (catA1, ABUW 0982), tetracycline resistance genes (tet(A), tet(B), tet(39)), and aminoglycoside modifying enzymes (aph(3′)-Ia, aph(3`)-Ic, aph(6)-Id, aac(3)-Ia). Additionally, eight novel OXA-51-like variants (OXA-970 to OXA-977) were characterized.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
The Plasmidomic Landscape of Clinical Methicillin-Resistant Staphylococcus aureus Isolates from Malaysia.
The study identified various plasmid-borne antimicrobial resistance genes in Malaysian MRSA isolates, including ermC, cat, tetK, tetL, aadD, aac(6')-Ie-aph(2")-Ia, lnuA, cadAC, cadDX, copB, mco, arsB, arsC, and qacA, contributing to multidrug resistance.
Investigating Possible Interspecies Communication of Plasmids Associated with Transfer of Third-Generation Cephalosporin, Quinolone, and Colistin Resistance Between Simultaneously Isolated Escherichia Coli and Klebsiella Pneumoniae.
The study identified multiple AMR genes in E. coli and K. pneumoniae isolates, including bla CTX-M-14, qnrS1, mcr-1.1, and others, highlighting the role of plasmids in the transfer of resistance genes between species.
Molecular Characterization of Extensively Drug Resistant Salmonella Enterica Serovar Typhi Clinical Isolates from Lahore, Pakistan.
The study identified multiple AMR genes in XDR Salmonella Typhi isolates from Lahore, Pakistan, including blaTEM-1, catA1, sul1, dhfR7, qnrS, gyrA, gyrB, parC, parE, blaCTX-M-U, blaCTX-M-1, and blaCTX-M-15, which confer resistance to various antibiotics such as ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, fluoroquinolones, and third-generation cephalosporins.
Hospital and community wastewater as a source of multidrug-resistant ESBL-producing Escherichia coli.
The study identifies several AMR genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-1, bla GES-5, bla OXA-244, qnrS1, qnrB4, aac(3)-IId, aph(3'')-Ib, aph(6)-Id, catA1, cmlA1, and bla TEM-1, which confer resistance to various antibiotics in multidrug-resistant ESBL-producing E. coli isolates from hospital and environmental sources.
Whole-Genome Sequencing Revealed the Fusion Plasmids Capable of Transmission and Acquisition of Both Antimicrobial Resistance and Hypervirulence Determinants in Multidrug-Resistant Klebsiella pneumoniae Isolates.
The study identified multiple antimicrobial resistance genes and hypervirulence determinants in multidrug-resistant Klebsiella pneumoniae isolates, highlighting the role of fusion plasmids in the transmission of these traits.
Expansion of healthcare-associated hypervirulent KPC-2-producing Klebsiella pneumoniae ST11/KL64 beyond hospital settings.
Two carbapenem-resistant K. pneumoniae strains (PINH-4250 and PINH-4900) were recovered from the Pinheiros River, carrying the blaKPC-2 carbapenemase gene and other resistance determinants. They exhibited a broad resistome and hypervirulent behavior.
Investigation of multidrug-resistant plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates from Pakistan.
The study identified 34 antimicrobial resistance genes (ARGs) in multidrug-resistant (MDR) plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates in Pakistan, including bla NDM-1, bla OXA-48, and various beta-lactamases, aminoglycoside resistance genes, and others.
Antibiotic Resistance/Susceptibility Profiles of Staphylococcus equorum Strains from Cheese, and Genome Analysis for Antibiotic Resistance Genes.
The study identified several antibiotic resistance genes in Staphylococcus equorum strains from cheese, including blaR1-blaZI, bla, mph(C), msr(A), norA, fosB/fosD, and cat, which confer resistance to various antibiotics such as beta-lactams, macrolides, fluoroquinolones, fosfomycin, and chloramphenicol.
Cutaneous Infection Associated With Myroides odoratimimus Bacteremia in a Diabetic Patient.
The case report identifies multidrug resistance in Myroides odoratimimus, including beta-lactamase genes bla-OXA-347 and bla-OXA-209, tetracycline resistance gene tetX, and chloramphenicol resistance gene cat.
Drug Resistance, Characterization and Phylogenetic Discrepancy of Salmonella enterica Isolates from Distinct Sources.
The study identified several AMR genes in Salmonella enterica isolates from clinical and animal sources, including catA1, blaTEM, and tetC, which confer resistance to chloramphenicol, ampicillin, and tetracycline, respectively.
Molecular characterization of multidrug resistant Acinetobacter baumannii clinical isolates from Alexandria, Egypt.
The study identified various AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Alexandria, Egypt, including bla OXA-51-like variants, bla OXA-23, bla NDM-1, bla PER-7, bla GES-like, and others, highlighting the widespread resistance to beta-lactams, aminoglycosides, tetracyclines, and other antibiotics.
Antimicrobial resistance and clonality of Staphylococcus aureus causing bacteraemia in children admitted to the Manhiça District Hospital, Mozambique, over two decades.
The study identifies various AMR genes in Staphylococcus aureus isolates from children with bacteraemia in Mozambique, including blaZ, mecA, tet(K), tet(L), tet(M), erm(C), msr(A), dfr(G), dfrA(S1), aacA-aphD, and cat pC221. Additionally, mutations in grlA and gyrA were found to confer ciprofloxacin resistance.
Elucidation of the Bovine Intramammary Bacteriome and Resistome from healthy cows of Swiss dairy farms in the Canton Tessin.
The study identified the presence of the tetracycline resistance gene tetK in Mammaliicoccus sciuri isolates, which was associated with tetracycline resistance. The gene was found on small plasmids, suggesting a potential mechanism for horizontal gene transfer.
Multidrug-Resistant and Extensively Drug-Resistant Acinetobacter baumannii Causing Nosocomial Meningitis in the Neurological Intensive Care Unit.
The study identified various AMR genes in 37 A. baumannii strains causing nosocomial meningitis, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, macrolide resistance genes, phenicol resistance genes, sulfonamide resistance genes, rifamycin resistance genes, and antiseptic resistance genes.
Genomic Insights into Listeria monocytogenes: Organic Acid Interventions for Biofilm Prevention and Control.
The study identified several antimicrobial resistance genes in Listeria monocytogenes, including Cat, Ide, mrsA, lin, fosX, mprF, vgaL, sul, norB, GyrA, GyrB, ParC, ParEm, FepR, and radC, which confer resistance to various antibiotics such as chloramphenicol, macrolides, lincosamides, streptogramins, phosphonic acids, peptides, fluoroquinolones, and sulfonamides.
Genomic characterization of colistin-resistant Klebsiella pneumoniae isolated from intensive care unit patients in Egypt.
The study identifies mcr-1.1 as a plasmid-mediated colistin resistance gene and characterizes several chromosomal mutations in mgrB, arnT, pmrA, pmrB, pmrC, phoQ, and arnB that contribute to colistin resistance in K. pneumoniae isolates from Egypt.
Phenotypic and genotypic antimicrobial resistance correlation and plasmid characterization in Salmonella spp. isolates from Italy reveal high heterogeneity among serovars.
The study identified several antimicrobial resistance genes including blaTEM-1B, sul1, sul2, tetA, tetB, and others in Salmonella isolates from Italy, highlighting the diversity of resistance mechanisms among different serovars.
Polyclonal Multidrug ESBL-Producing Klebsiella pneumoniae and Emergence of Susceptible Hypervirulent Klebsiella pneumoniae ST23 Isolates in Mozambique.
The study identified multiple AMR genes in Klebsiella isolates, including bla CTX-M-15, bla TEM-1, bla SHV, and bla OXA-1, which confer resistance to beta-lactams. Other genes like aac(3)-IIa, aac(6')-Ib-cr, qnrB1, qnrB6, catA1, catA2, catB3, dfrA5, dfrA7, dfrA12, dfrA14, dfrA27, sul1, sul2, mph(A), tet(A), tet(D), fosA, ARR-3, and oqxAB were also found, contributing to resistance against aminoglycosides, quinolones, chloramphenicol, trimethoprim, sulfamethoxazole, macrolides, tetracycline, fosfomycin, rifampicin, and quinolones respectively. Mutations in ompK36, ompK37, and acrR were associated with resistance to cephalosporins and fluoroquinolones, while mutations in RamR were linked to tigecycline resistance.
Probiotics Modulate Host Immune Response and Interact with the Gut Microbiota: Shaping Their Composition and Mediating Antibiotic Resistance.
The study identifies tetracycline resistance genes (tetM, tetL) and a fluoroquinolone resistance gene (parC) in probiotic strains, highlighting the potential for probiotics to mediate antibiotic resistance.
A paradox of bacterial persistence and antibiotic resistance: chloramphenicol acetyl transferase as a double barrel shot gun.
The study demonstrates that the presence of the chloramphenicol acetyl transferase (cat) gene in Salmonella Typhimurium reduces persistence levels when exposed to various antibiotics, including fluoroquinolones and cefotaxime, in the presence of chloramphenicol.
Genomic Landscape of Multidrug Resistance and Virulence in Enterococcus faecalis IRMC827A from a Long-Term Patient.
The study identifies multiple antimicrobial resistance genes and mutations in Enterococcus faecalis IRMC827A, including cat, tet_efflux, dfr, and mutations in 23S rRNA, gyrA, and parC associated with resistance to chloramphenicol, tetracycline, trimethoprim, linezolid, and fluoroquinolones.
First Report and Characterization of the mcr-1 Positive Multidrug-Resistant Escherichia coli Strain Isolated from Pigs in Croatia.
The study reports the first mcr-1 positive multidrug-resistant E. coli strain isolated from pigs in Croatia. The strain was resistant to colistin, gentamicin, ampicillin, cefepime, cefotaxime, ceftazidime, sulfamethoxazole, chloramphenicol, nalidixic acid, and ciprofloxacin. The mcr-1 gene was located on an IncX4 plasmid, along with other resistance genes such as bla TEM-1B, bla CTX-M-1, aac(3)-IId, aph(3’)-Ia, aadA5, sul2, and catA1. Mutations in gyrA (S83L, D87N) and parC (A56T, S80I) were also identified, contributing to fluoroquinolone resistance.
Phylogenomics, phenotypic, and functional traits of five novel (Earth-derived) bacterial species isolated from the International Space Station and their prevalence in metagenomes.
Five novel bacterial species were isolated from the International Space Station (ISS) and characterized. These species, Arthrobacter burdickii, Leifsonia virtsii, Leifsonia williamsii, Paenibacillus vandeheii, and Sporosarcina highlanderae, were identified through phylogenomic, phenotypic, and functional analyses. Their genomes were sequenced, and they were distinguished from known species using ANI and dDDH values, as well as gyrB gene sequence similarities.
Phylogenomics, phenotypic, and functional traits of five novel (Earth-derived) bacterial species isolated from the International Space Station and their prevalence in metagenomes.
Five novel bacterial species were isolated from the International Space Station (ISS) and characterized. These species, Arthrobacter burdickii, Leifsonia virtsii, Leifsonia williamsii, Paenibacillus vandeheii, and Sporosarcina highlanderae, were identified through phylogenomic, phenotypic, and functional analyses. Their genomes were sequenced, and they were distinguished from known species using ANI and dDDH values, as well as gyrB gene sequence similarities.
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
Study of heavy metal resistance genes in Escherichia coli isolates from a marine ecosystem with a history of environmental pollution (arsenic, cadmium, copper, and mercury).
The study identified several heavy metal resistance genes (HMRGs) in Escherichia coli isolates from a marine ecosystem with a history of environmental pollution, highlighting the prevalence of these genes and their potential interactions with antibiotic resistance genes.
Resistome and virulome of high-risk pandemic clones of multidrug-resistant extra-intestinal pathogenic Escherichia coli (ExPEC) isolated from tertiary healthcare settings in Uganda.
The study identified various AMR genes in multidrug-resistant E. coli isolates, including blaCTX-M-15, blaTEM-1B, blaOXA-1, and others, which confer resistance to beta-lactams, aminoglycosides, sulfonamides, tetracyclines, macrolides, and quinolones. Additionally, chromosomal mutations in gyrA and parC were found to contribute to fluoroquinolone resistance.
Prevalence and genomic characterization of Salmonella isolates from commercial chicken eggs retailed in traditional markets in Ghana.
The study identified several AMR genes and mutations in Salmonella isolates from chicken eggs in Ghana, including aadA1, aph(3")-Ib, aph(6)-Id, catA1, dfrA1, dfrA14, fosA7.2, qnrB19, sul1, sul2, and tet(A), as well as mutations in gyrA (D87N) and gyrA (S83Y).
Prevalence and antibiotics resistance status of Salmonella in raw meat consumed in various areas of Lahore, Pakistan.
The study identified the presence of bla TEM-1, catA1, and gyrA genes in Salmonella isolates from raw meat in Lahore, Pakistan, indicating resistance to Ampicillin, Chloramphenicol, and Quinolones.
Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance.
The study identified multiple antimicrobial resistance genes and mutations in Shigella isolates from Lebanon, including bla CTX-M-15 and bla CTX-M-3 for extended-spectrum beta-lactamase resistance, and gyrA mutations for quinolone resistance.
Low temperatures do not impair the bacterial plasmid conjugation on poultry meat.
The study demonstrates that non-pathogenic E. coli can acquire an IncB/O-plasmid carrying multiple antimicrobial resistance genes through conjugation on poultry meat, even at low temperatures. This highlights the potential risk of antimicrobial resistance spread through food products.
Enterococcus species: insights into antimicrobial resistance and whole-genome features of isolates recovered from livestock and raw meat in Ghana.
The study identified various antimicrobial resistance genes in Enterococcus spp. isolated from livestock and raw meat in Ghana, including genes conferring resistance to erythromycin, tetracycline, chloramphenicol, and other antibiotics. Notable genes include aac(6')-Ii, aph(3')-III, ant(6)-Ia, erm(B), erm(T), msr(C), lsa(A), lsa(E), lnu(B), tet(L), tet(M), tet(S), dfrG, cat, pbp5, and ClpL.
Genomic investigation unveils high-risk ESBL producing Enterobacteriaceae within a rural environmental water body.
The study identifies several AMR genes and mutations in ESBL-producing Enterobacteriaceae isolated from a rural environmental water body in India, highlighting the presence of multidrug-resistant strains with genes such as bla VEB-6, bla SHV-12, bla NDM-1, bla CTX-M, and mcr-9, along with mutations in ompK 36 and gyrA.
Genomic insights into ESBL-producing Escherichia coli isolated from non-human primates in the Peruvian Amazon.
The study identified three bla CTX-M variants (bla CTX-M-15, bla CTX-M-55, and bla CTX-M-65) and a broad resistome in ESBL-producing E. coli strains isolated from non-human primates in the Peruvian Amazon.
Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021.
The study identified various antimicrobial resistance genes and mutations in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain, highlighting the presence of multidrug-resistant strains and the role of plasmids in the dissemination of resistance mechanisms.
In-depth characterization of multidrug-resistant NDM-1 and KPC-3 co-producing Klebsiella pneumoniae bloodstream isolates from Italian hospital patients.
The study characterized multidrug-resistant NDM-1 and KPC-3 co-producing Klebsiella pneumoniae bloodstream isolates, identifying several AMR genes and mutations associated with resistance to various antibiotics.
Genomic analysis of Salmonella isolated from canal water in Bangkok, Thailand.
The study identified 35 AMR genes and 30 chromosomal-mediated gene mutations in Salmonella strains from Bangkok canal water, highlighting the presence of multidrug-resistant strains with resistance to various antimicrobial classes.
Predominance of multidrug-resistant Salmonella Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar.
The study identifies multidrug-resistant Salmonella Typhi genotype 4.3.1.1 with low-level ciprofloxacin resistance in Zanzibar, highlighting the presence of resistance genes blaTEM-1B, sul1, sul2, dfrA7, catA1, aph(6)-Id, and aph(3")-Ib, along with gyrA mutations D87G and S83F.
Streptococcus suis serotype 4: a population with the potential pathogenicity in humans and pigs.
The study identified multiple antibiotic resistance genes in Streptococcus suis serotype 4, including genes conferring resistance to tetracyclines, macrolides, lincosamides, aminoglycosides, oxazolidinones, and chloramphenicol. Prophages were identified as the primary vehicle for the dissemination of these resistance genes.
Longitudinal analysis within one hospital in sub-Saharan Africa over 20Â years reveals repeated replacements of dominant clones of Klebsiella pneumoniae and stresses the importance to include temporal patterns for vaccine design considerations.
The study identifies the widespread presence of blaCTX-M-15, catA1, catA2, aac(6')-Ib, aac(3)-II, and aadB genes in Klebsiella pneumoniae isolates, contributing to resistance against beta-lactams, chloramphenicol, and aminoglycosides.
Prevalence of antibiotic-resistant Acinetobacter spp. on soil and crops collected from agricultural fields in South Korea.
The study identified several antibiotic resistance genes in Acinetobacter spp. isolated from agricultural fields in South Korea, including emrAB, cat, craA, and aadA, which confer resistance to colistin, chloramphenicol, and streptomycin.
Complete genome sequence of the linezolid-resistant clinical Enterococcus faecalis N23-3408 linked to a livestock lineage in Switzerland.
The linezolid-resistant E. faecalis N23-3408 harbors the optrA gene on a plasmid, along with other resistance genes including cat, erm(B), fexA, tet(L), and tet(M).
Genomic analysis of multidrug-resistant Escherichia coli from Urban Environmental water sources in Accra, Ghana, Provides Insights into public health implications.
The study identified several AMR genes in multidrug-resistant E. coli isolates from urban environmental water sources in Accra, Ghana, highlighting the presence of beta-lactamases (blaTEM-1B, blaCTX-M-15, blaTEM-1C, blaDHA-1, blaOXA-1, blaOXA-181), sulfonamide resistance genes (sul2, sul1), aminoglycoside resistance genes (aph(6)-Id, aadA2, mph(A)), quinolone resistance gene (qnrS1), tetracycline resistance gene (tet(B)), chloramphenicol resistance gene (catA1), dihydrofolate reductase (dfrA14), and others.
Occurrence, molecular characterization, and antimicrobial susceptibility of sorbitol non-fermenting Escherichia coli in lake water, fish and humans in central Oromia, Ethiopia.
The study identified multiple antimicrobial resistance genes in sorbitol non-fermenting E. coli strains, including blaTEM-1B, tet(A), dfrA1, dfrA5, sul1, fos7, catA1, qnrS1, gyrA, and blaCTX-M15, which conferred resistance to various antibiotics such as ampicillin, tetracycline, trimethoprim, sulfamethoxazole, fosfomycin, chloramphenicol, ciprofloxacin, nalidixic acid, and extended-spectrum beta-lactams.
Genomic characterisation of Escherichia coli isolated from poultry at retail through Sink Surveillance in Dhaka, Bangladesh reveals high levels of multi-drug resistance.
The study identified multiple AMR genes in E. coli isolates from poultry in Bangladesh, including genes conferring resistance to various antibiotics such as tetracycline, ciprofloxacin, azithromycin, colistin, and others. High levels of multidrug resistance were observed, with specific genes like mcr1.1, bla CTX-M-65, and tet(A) playing significant roles.
Salmonella Typhi Haplotype 58 (H58) Biofilm Formation and Genetic Variation in Typhoid Fever Patients with Gallstones in an Endemic Setting in Kenya.
The study identified multidrug resistance genes such as sul1, dfrA7, catA1, aph(6)-Id, aph(3")-Ib, sul2, and blaTEM-1 in S. Typhi isolates from patients with gallstones. Additionally, point mutations in the quinolone resistance determining region (QRDR) of gyrA (S83Y) and gyrB (S464F) were observed, contributing to resistance against ciprofloxacin and nalidixic acid.
Costs of antibiotic resistance genes depend on host strain and environment and can influence community composition.
The study identifies that certain antibiotic resistance genes (ARGs) such as bla TEM-116 *, cat, and dfrA5 impose fitness costs in various Escherichia spp. strains, highlighting the variability of these effects across different host backgrounds.
The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi.
The study identifies multiple antimicrobial resistance (AMR) genes and mutations in Salmonella Typhi H58 lineage, highlighting its multidrug resistance and the role of IncH1 plasmids in conferring resistance to various antibiotics.
Nucleotide sequence analysis of the cat gene of Proteus mirabilis: comparison with the type I (Tn9) cat gene.
The cat gene in Proteus mirabilis mediates chloramphenicol resistance through increased mRNA levels and shows homology with the Tn9 cat gene.
Nucleotide sequence analysis of the cat gene of Proteus mirabilis: comparison with the type I (Tn9) cat gene.
Nucleotide sequence analysis of the chloramphenicol resistance transposon Tn9.
Nucleotide sequence analysis of the chloramphenicol resistance transposon Tn9.
Nucleotide sequence analysis of the chloramphenicol resistance transposon Tn9.
Nucleotide sequence analysis of the chloramphenicol resistance transposon Tn9., A chromosomal chloramphenicol acetyltransferase determinant from a probiotic strain of Bacillus clausii., Chloramphenicol resistance in Campylobacter coli: nucleotide sequence, expression, and cloning vector construction., Cloning and nucleotide sequence analysis of a chloramphenicol acetyltransferase gene from Vibrio anguillarum.
ST913-IVa-t991 Methicillin-Resistant Staphylococcus aureus among Pediatric Patients, Israel.
The study identified two AMR genes, ermC and cat, associated with erythromycin, clindamycin, and chloramphenicol resistance in t991 MRSA isolates from Israel. These findings highlight the genetic diversity and resistance mechanisms of this emerging MRSA lineage.
Salmonella Typhi genotypic diversity, cluster identification and antimicrobial resistance determinants in Mukuru settlement, Nairobi Kenya.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella Typhi isolates from Mukuru settlement, Nairobi, Kenya, highlighting the prevalence of multidrug-resistant strains.
Mobile genetic elements define the non-random structure of the Salmonella enterica serovar Typhi pangenome.
The study identifies multiple AMR genes, including blaTEM-1B, qnrS1, sul2, tet(A), aph(3'')-Ib, aph(6)-Id, dfrA14, blaCTX-M-15, blaCTX-M-88, catA1, qacE, sul1, and tet(B), which are associated with multidrug-resistant and extensively drug-resistant Salmonella enterica serovar Typhi strains.
In vivo fitness of sul gene-dependent sulfonamide-resistant Escherichia coli in the mammalian gut.
The study identifies the sul2 gene as conferring sulfonamide resistance in E. coli and characterizes compensatory mutations, including the spoT A26E mutation, which may enhance fitness in the mammalian gut.
Synonymous codon substitutions modulate transcription and translation of a divergent upstream gene by modulating antisense RNA production.
Synonymous codon substitutions in the cat gene can increase tetR expression by activating an intragenic TSS, leading to higher TetR protein levels and subsequent repression of cat transcription.
Unde venis? Bacterial resistance from environmental reservoirs to lettuce: tracking microbiome and resistome over a growth period.
The study identified multidrug and β-lactam antibiotic resistance genes (ARGs) in lettuce and water, while lettuce and soil uniquely shared mainly glycopeptide and tetracycline ARGs. Manure was found to be the main source of resistance markers on young lettuce plants.
Methods for Genetic Manipulation of Neisseria gonorrhoeae
This paper describes methods for genetic manipulation of Neisseria gonorrhoeae and commensal Neisseria species, focusing on transformation techniques, mutagenesis, and complementation strategies.
A nisin-inducible chromosomal gene expression system based on ICE Tn5253 of Streptococcus pneumoniae, transferable among streptococci and enterococci.
The study presents a nisin-inducible chromosomal gene expression system based on ICE Tn5253 of Streptococcus pneumoniae, which allows for the controlled expression of genes in various streptococci and enterococci. The system includes the nisRK regulatory system and the PnisA promoter, enabling inducible gene expression. The system was validated through cloning, transformation, and expression of the emm6.1::ha1 fusion gene, demonstrating successful integration and expression in multiple bacterial species.
Antibiotic Resistance Genes and Plasmid Characteristics in Enterobacteriaceae Isolated from Fresh Produce
The study identified several antibiotic resistance genes on plasmids and chromosomes of Enterobacteriaceae strains isolated from fresh produce, highlighting the diversity of resistance mechanisms and the potential for horizontal gene transfer.
Genetic landscape of ESBL producing international clone ST410 of Escherichia coli from pediatric infections in Shenzhen, China.
The study identifies multiple ESBL genes, including bla CTX-M, bla TEM, and bla SHV, along with other resistance genes such as bla OXA-1, bla KPC-2, bla NDM-1, and others, contributing to multidrug resistance in E. coli ST410 isolates from pediatric infections in Shenzhen, China.
Genomic Characterization of Extended-Spectrum β-Lactamase-Producing and Third-Generation Cephalosporin-Resistant Escherichia coli Isolated from Stools of Primary Healthcare Patients in Ethiopia.
The study identified multiple antimicrobial resistance genes in E. coli isolates, including bla CTX-M-15, bla TEM-1B, tet(A), qnrS1, and others, highlighting the prevalence of multidrug resistance in the region.
Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase-producing Enterobacterales.
The study identifies catA1, catA2, catB3, catB4, cmlA1, and floR as functional chloramphenicol resistance genes, while catB4 is a non-functional variant due to IS 26-mediated truncation. IS 5 insertion into the catA1 promoter and IS 26-mediated deletion of catB3 lead to reduced or absent chloramphenicol resistance.
Analyzing Antibiotic Resistance in Bacteria from Wastewater in Pakistan Using Whole-Genome Sequencing.
The study identifies several AMR genes and mutations in wastewater isolates from Pakistan, highlighting the presence of carbapenemases like blaNDM-5 and blaOXA-1, as well as quinolone resistance determinants such as gyrA and parC mutations. These findings emphasize the role of wastewater as a reservoir for clinically relevant AMR genes.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Limited Evidence of Spillover of Antimicrobial-Resistant Klebsiella pneumoniae from Animal/Environmental Reservoirs to Humans in Vellore, India.
The study found that clinical and hospital sewage isolates of Klebsiella pneumoniae had a higher number of AMR genes compared to livestock isolates, suggesting that AMR is more prevalent in human-associated settings. Several beta-lactamase genes, including blaCTX-M, blaNDM, blaKPC, and blaOXA-48, were detected in clinical isolates, contributing to resistance against carbapenems and other antibiotics. Other AMR genes such as qnrS1, aac(6')-Ib, aadA, ermB, mefA, tet(A), mph(A), cat, cfr, vanA, mcr-1, fosA, sul1, and dfrA1 were also identified, highlighting the diversity of resistance mechanisms in K. pneumoniae.
Detection and genetic characterization of multidrug-resistant staphylococci isolated from public areas in an international airport.
The study identified multiple multidrug-resistant staphylococci, including methicillin-resistant S. haemolyticus, S. epidermidis, and a livestock-associated MRSA (LA-MRSA) strain, carrying various resistance genes such as mecA, blaZ, erm(C), aac(6')-aph(2''), and others, highlighting the presence of AMR in public environments.
Genome and antibiotic resistance characteristics of Shigella clinical isolates in Fujian Province, Southeast China, 2005-2019.
The study identified various AMR genes in Shigella isolates from Fujian Province, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla CTX-M-64), macrolide resistance genes (mphA, ermB), tetracycline resistance genes (tetA, tetB), aminoglycoside resistance genes (aadA, aph(3')-Ib, aac(3)-IId), chloramphenicol resistance gene (catA1), and sulfonamide/trimethoprim resistance genes (sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA17).
Whole genome sequencing revealed high proportions of ST152 MRSA among clinical Staphylococcus aureus isolates from ten hospitals in Ghana.
The study identified high proportions of ST152 MRSA among clinical S. aureus isolates in Ghana, with blaZ, mecA, cat, tetK, and dfrG being the most prevalent resistance genes.
Antimicrobial resistance, virulence factors and phylogenetic profiles of Vibrio parahaemolyticus in the eastern coast of Shenzhen.
The study identified several antimicrobial resistance genes in Vibrio parahaemolyticus isolates from Shenzhen, including blaCARB, tet(34), tet(35), qnrVC6, sul2, aph(6)-Id, floR, cat, and blaCTX-M-14. These genes conferred resistance to various antibiotics such as ampicillin, tetracycline, fluoroquinolones, sulfonamides, aminoglycosides, chloramphenicol, and beta-lactams.
Data-Driven Approaches in Antimicrobial Resistance: Machine Learning Solutions.
This study uses unsupervised machine learning to identify patterns in AMR genes, linking gene length and resistance class to resistance mechanisms. Key AMR genes identified include sul1, sul2, cat, blaTEM, vanA, aac(6')-Ib, aph(3')-IIIa, tet(M), and tet(O).
Salmonella Typhi Haplotype 58 biofilm formation and genetic variation in isolates from typhoid fever patients with gallstones in an endemic setting in Kenya.
The study identified multidrug resistance genes sul1, dfrA7, catA1, aph(6)-Id, aph(3" )-Ib, sul2, and blaTEM-1 in S. Typhi isolates from household D, along with specific mutations in the quinolone resistance-determining region (QRDR) of gyrA and gyrB. Additionally, missense mutations in the treB and tviE genes were observed in isolates from different households.
Microbial spectrum and resistance of odontogenic abscesses - microbiological analysis using next generation sequencing.
The study identified multiple AMR genes in odontogenic abscesses using NGS, including genes conferring resistance to tetracyclines, macrolides, lincosamides, aminoglycosides, chloramphenicol, sulfonamides, penicillins, and others. Notably, Fusobacterium showed resistance to clindamycin.
The healthy human gut can take it all: vancomycin-variable, linezolid-resistant strains and specific bacteriocin-species interplay in Enterococcus spp.
The study identifies linezolid resistance genes optrA and poxtA in Enterococcus faecium and Enterococcus thailandicus isolates, along with a vancomycin-variable E. faecium strain. It also reveals the increasing prevalence of E. lactis in the healthy human gut and the complex interplay of bacteriocin gene profiles among Enterococcus species.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Prevalence and genomic insights of carbapenem resistant and ESBL producing Multidrug resistant Escherichia coli in urinary tract infections.
The study identified multiple AMR genes, including NDM-5, CTX-M-15, TEM-1, and others, in carbapenem-resistant and ESBL-producing multidrug-resistant E. coli isolates from urinary tract infections.
Molecular Epidemiology and In-Depth Characterization of Klebsiella pneumoniae Clinical Isolates from Armenia.
The study identifies multiple AMR genes and mutations in K. pneumoniae isolates from Armenia, highlighting the presence of XDR and MDR strains with resistance to various antibiotics, including carbapenems, aminoglycosides, and quinolones.
The rise in domestic shigellosis and the genomic characteristics of Shigella clones linked to men who have sex with men in Taiwan, 2015‒2022.
The study identifies several AMR genes and mutations in Shigella clones associated with men who have sex with men (MSM) in Taiwan, highlighting the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains.
Genomic epidemiology and antimicrobial resistance of Morganella clinical isolates between 2016 and 2023.
The study identified several AMR genes in Morganella clinical isolates, including tet(B), sul1, catA2, sul2, floR, aadA1, and others, contributing to resistance against various antibiotics.
Whole-Genome Sequencing of Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Isolated from Human Bloodstream Infections.
The study identified multiple AMR genes in ESBL-producing K. pneumoniae isolates, including blaCTX-M-15, blaKPC-3, and others conferring resistance to β-lactams, aminoglycosides, fluoroquinolones, sulfonamides, tetracyclines, and chloramphenicol.
Intestinal and Extraintestinal Pathotypes of Escherichia coli Are Prevalent in Food Prepared and Marketed on the Streets from the Central Zone of Mexico and Exhibit a Differential Phenotype of Resistance Against Antibiotics.
The study identifies multiple antibiotic resistance genes in E. coli isolates from street-prepared food in Mexico, including strA, sul1, catA1, floR, qnrS, and tetA, which confer resistance to streptomycin, sulfonamides, chloramphenicol, quinolones, and tetracycline.
Molecular characterization of multidrug-resistant E. coli recovered from diarrheagenic children under 5 years from Mukuru Informal Settlement, Nairobi, Kenya, based on whole-genome sequencing analysis.
The study identified multiple AMR genes and mutations in multidrug-resistant E. coli isolates from diarrheagenic children in Nairobi, Kenya, highlighting the presence of blaTEM-1B, blaCTX-M-15, qnrS1, qnrB4, aac(6')-Ib-cr, and other resistance mechanisms.
Transmissible antimicrobial resistance in Escherichia coli isolated from household drinking water in Ibadan, Nigeria.
The study identified several AMR genes in E. coli isolates from household water in Ibadan, Nigeria, including blaTEM-1B, dfrA14, tetA, qnrS1, and mcr-1, highlighting the potential for horizontal gene transfer and the risk of AMR spread in the environment.
Curcumin Reverses Antibiotic Resistance and Downregulates Shiga Toxin Expression in Enterohemorrhagic E. coli.
Curcumin reverses antibiotic resistance in Enterohemorrhagic E. coli by downregulating the expression of beta-lactamase (bla CTX-M-15), chloramphenicol acetyltransferase (catA1), and efflux pump genes (acrA, acrB, tolC).
Acquired antibiotic resistance of Pseudomonas spp., Escherichia coli and Acinetobacter spp. in the Western Balkans and Hungary with a One Health outlook.
The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.
Antimicrobial resistance and virulence gene profiles of Escherichia coli isolated from poultry farms using One Health perspective in Abeokuta, Nigeria.
The study identified 30 different resistance determinants in 14 whole genome sequenced E. coli isolates from poultry farms in Abeokuta, Nigeria. These included genes such as blaTEM-1B, blaCARB-2, aph(3'')-Ib, aph(6)-Id, floR, sul1, sul2, tet(A), and tet(B), among others, which conferred resistance to various antimicrobial classes.
Population Structure, Genomic Features, and Antibiotic Resistance of Avian Pathogenic Escherichia coli in Shandong Province and Adjacent Regions, China (2008-2023).
The study identified multiple antibiotic resistance genes and mutations in Avian Pathogenic Escherichia coli (APEC) isolates from Shandong Province and adjacent regions in China, highlighting the high prevalence of multidrug resistance and the presence of specific resistance mechanisms such as beta-lactamases, tetracycline resistance genes, and fluoroquinolone resistance mutations.
Staphylococcus epidermidis in Acute Myeloid Leukemia: A Comparative Genomic Study Against Non-AML Isolates.
The study identified several AMR genes in S. epidermidis isolates from AML patients, including mecA, mecR1, qacA, ermC, tetM, cfrA, ANT(4′)-Ib, blaZ, dfrG, cat, and mecI, which were associated with increased resistance to various antibiotics.
Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance.
The study presents a framework to predict no-effect concentrations for antibiotic resistance selection in the environment by integrating minimum inhibitory concentration (MIC) data with resistance-related fitness costs. It identifies various AMR genes and their resistance profiles through competition experiments.
Genomic characterization of multidrug-resistant clinical Acinetobacter baumannii isolates from a hospital in Paraguay.
The study identified multiple AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Paraguay, including blaOXA-23, blaOXA-66, blaOXA-65, blaADC-73, blaADC-5, blaTEM-1, and various aminoglycoside, macrolide, sulfonamide, chloramphenicol, tetracycline, and trimethoprim resistance genes.
Outbreak Caused by VIM-1- and VIM-4-Positive Proteus mirabilis in a Hospital in Zagreb.
The study reports an outbreak of carbapenem-resistant Proteus mirabilis in a psychiatric hospital in Zagreb, Croatia, characterized by the presence of VIM-1 and VIM-4 carbapenemases, along with other resistance genes such as bla CTX-M-15, bla TEM, and aminoglycoside resistance genes.
Global phylogeography and genomic characterization of bla(NDM-1)-positive clinical Proteus mirabilis isolates from China.
The study identifies blaNDM-1 as a key determinant of carbapenem resistance in Proteus mirabilis isolates from China, along with other resistance genes such as blaCTX-M-14, blaCTX-M-65, and blaTEM-1. It also characterizes the genomic context of blaNDM-1, including its integration into SGI1 and plasmid-borne elements.
Antibiotic resistance and novel Sequence Types of Klebsiella spp. in human, animal, and food sources: a One Health perspective from Northern Nigeria.
The study identified various AMR genes in Klebsiella spp. isolates from human, animal, and food sources, including strB, qnrS1, sul2, tetA, dfrA14, blaTEM-1, and blaSHV-11, which conferred resistance to multiple antibiotics.
Unveiling community structure, antimicrobial resistance, and virulence factor of a wastewater sample of dairy farm located in mayurbhanj, odisha, india.
The study identified several antimicrobial resistance (AMR) genes in a dairy wastewater sample, including beta-lactamases, aminoglycoside acetyltransferases, tetracycline resistance proteins, quinolone resistance proteins, and macrolide ribosome methyltransferases. These genes were found in various bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Molecular Epidemiology, Antimicrobial Resistance, and Virulence Profiles of Staphylococcus aureus from Fish, Aquatic Environments, and Fish Handlers in Southeast Nigeria.
The study identified 19 antimicrobial resistance genes in Staphylococcus aureus isolates from fish, aquatic environments, and fish handlers in Southeast Nigeria, highlighting the presence of multidrug-resistant strains with various resistance mechanisms.
Whole-genome sequencing reveals Enterobacter hormaechei as a key bloodstream pathogen in six tertiary care hospitals in southwestern Nigeria.
The study identifies several AMR genes in Enterobacter hormaechei and Enterobacter cloacae, including bla ACT-45, bla CTX-M-15, bla NDM-1, dfrA14, mcr10.1, aac(3)-Ile, aph(3′)-Ib, qnrB1, sul1, sul2, tet(A), catA1, and mphA, highlighting the prevalence of multidrug resistance in these species.
Whole-Genome Sequencing Analysis of Drug-Resistant Salmonella Typhi in Children.
The study identified several AMR genes and mutations in drug-resistant Salmonella Typhi isolates from children, including bla_CTXM15, bla_TEM1B, qnrS1, aac6'Ia, catA1, dfrA7, sul1, qacEΔ1, and the gyrA_S83F mutation, which are associated with resistance to various antibiotics such as ciprofloxacin, ampicillin, chloramphenicol, and sulfamethoxazole.
Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus.
The study identifies Eis2 as an aminoglycoside-modifying enzyme that activates florfenicol amine (FF-NH2) by acetylating it to form FF-ac, a more potent translational inhibitor. Mutations in whiB7 and eis2 decrease susceptibility to FF-NH2.
Multidrug resistant hypervirulent ST307 clone from genomic surveillance of extended spectrum beta-lactamase-producing Klebsiella pneumoniae species complex in East Africa.
The study identifies multiple AMR genes, including blaCTX-M-15, blaTEM-1D, aac(6')-Ib-cr, aadA16, strB, qnrS1, sul2, sul1, catII.2, tet(A), dfrA14, arr-3, and mphA, in ESBL-KpSC isolates from East Africa, highlighting the prevalence of multidrug resistance.
Global geographic and genomic epidemiology analysis of carbapenem-resistant Escherichia coli carrying bla(NDM-9).
The study characterizes bla NDM-9 -carrying carbapenem-resistant Escherichia coli (CREC) and identifies various antibiotic resistance genes (ARGs) contributing to multidrug resistance. It highlights the role of mobile genetic elements in the dissemination of bla NDM-9 and emphasizes the importance of surveillance for these high-risk clones.
An integrated phenotypic and genomic approach to characterize MBL-producing Enterobacterales strains circulating in a Sicilian transplant center.
The study characterizes MBL-producing Enterobacterales strains, identifying NDM-1, NDM-5, and VIM-1 as the most prevalent metallo-beta-lactamases. It also identifies various aminoglycoside, quinolone, and sulfonamide resistance genes, highlighting the multidrug-resistant nature of these isolates.
Unveiling the Mechanisms of Bacterial Resistance and Countermeasures.
The paper discusses various mechanisms of bacterial resistance, including intrinsic resistance, acquired resistance, and adaptive resistance, focusing on genetic mutations, efflux pumps, and enzymatic modifications.
Unraveling the Prevalence and Multifaceted Roles of Accessory Peptide Deformylases in Bacterial Adaptation and Resistance.
The study identifies Def2 VCH, VaDef, VkDef, and PsDef as accessory peptide deformylases that confer resistance to actinonin and other PDF inhibitors in various bacterial species, highlighting their role in bacterial adaptation and resistance.
Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock.
The study identified multiple AMR genes in Citrobacter freundii isolates from Egyptian livestock, including bla TEM, bla CTX-M, bla OXA-10, bla CMY-2, qnrA, aadA1, sul2, dfrA1, ermB, tet(M), int1, and mcr-1, which confer resistance to various antibiotics.
Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock.
The study identified multiple AMR genes in Citrobacter freundii isolates from Egyptian livestock, including bla TEM, bla CTX-M, bla OXA-10, bla CMY-2, qnrA, aadA1, sul2, dfrA1, ermB, tet(M), int1, and mcr-1, which confer resistance to various antibiotics.
Research of antimicrobial resistance and its associated genes distribution in Escherichia coli from diarrheic calves in the Ulagai region of China.
The study identified several antimicrobial resistance genes in E. coli isolates from diarrheic calves in the Ulagai region of China, including sul2, TEM-1, tetR, strB, QacH, floR, and CTXM-55, which were associated with resistance to various antibiotics.
PanARGMiner (Pan-Genomic Antimicrobial Resistance Gene Miner): An advanced feature selection framework for extracting key resistance genes from pan-genomic datasets.
PanARGMiner effectively identifies key resistance genes from pan-genomic datasets, including both known and novel AMR genes, across multiple bacterial species.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
Multidrug-resistant gram-negative bacteria in Spanish ICU patients: clinical and microbiological characterization (MURAN-UCI Project).
The study identifies several AMR genes and mutations in multidrug-resistant gram-negative bacteria, including bla VIM-1, bla CTX-M-15, bla OXA-48, and mutations in oprD, mexR, and nalD, contributing to resistance against various antibiotics.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
The study identified mcr-1.1-harboring multidrug-resistant E. coli isolates from chicken in the UAE, highlighting the presence of various AMR genes and mutations contributing to resistance against multiple antibiotics, including colistin, beta-lactams, quinolones, and aminoglycosides.
The production of chloramphenicol acetyltransferase by bacteriophage P1CM.
Bacteriophage P1CM produces chloramphenicol acetyltransferase, an enzyme that confers resistance to chloramphenicol by acetylating the antibiotic.
Nucleotide sequence and functional map of pC194, a plasmid that specifies inducible chloramphenicol resistance.
The study identified the cat gene on plasmid pC194, which encodes chloramphenicol acetyltransferase and confers inducible chloramphenicol resistance in Staphylococcus aureus and Escherichia coli.
Chloramphenicol resistance in Haemophilus influenzae.
A strain of Haemophilus influenzae was found to be resistant to chloramphenicol and tetracycline, with resistance to chloramphenicol attributed to the production of a chloramphenicol acetyltransferase enzyme.
Rapid detection of chloramphenicol resistance in Haemophilus influenzae.
The study describes a rapid method for detecting chloramphenicol resistance in Haemophilus influenzae, involving the identification of chloramphenicol acetyltransferase activity.
Inactivation of chloramphenicol by O-phosphorylation. A novel resistance mechanism in Streptomyces venezuelae ISP5230, a chloramphenicol producer.
The study identifies a novel chloramphenicol resistance mechanism in Streptomyces venezuelae ISP5230 involving the enzyme chloramphenicol 3'-O-phosphotransferase, which inactivates chloramphenicol through O-phosphorylation.
The structure of the chloramphenicol resistance gene on a transferable R plasmid from the fish pathogen, Pasteurella piscicida.
The structure of the chloramphenicol resistance gene on a transferable R plasmid from the fish pathogen, Pasteurella piscicida.
Construction of new Campylobacter cloning vectors and a new mutational cat cassette.
The study describes the construction of new Campylobacter cloning vectors and a mutational cat cassette for site-specific mutagenesis. The cat gene from Campylobacter was cloned and characterized for chloramphenicol resistance.
Molecular characterization of penicillin-resistant Streptococcus pneumoniae isolates from Bulgaria.
The study identified multiple penicillin-resistant Streptococcus pneumoniae isolates from Bulgaria, characterizing their resistance mechanisms through molecular techniques. Key findings include the identification of specific penicillin-binding protein genes (pbp1a, pbp2b, pbp2x) and resistance genes (ermB, mefE, tetM, cat) associated with resistance to penicillin, erythromycin, tetracycline, and chloramphenicol.
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