Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Acytelytransferase
Overview
Analysis of the resistome of a multidrug-resistant NDM-1-producing Escherichia coli strain by high-throughput genome sequencing.
The study identified multiple AMR genes in a multidrug-resistant E. coli strain, including blaNDM-1, blaTEM-1, blaCTX-M-15, and others, along with chromosomal mutations in gyrA, parC, ompC, and ompF contributing to resistance.
Copy Number Change of the NDM-1 sequence in a multidrug-resistant Klebsiella pneumoniae clinical isolate.
The study identifies the blaNDM-1 gene on plasmid pKPX-1 as a key factor in carbapenem resistance in a multidrug-resistant Klebsiella pneumoniae isolate. It also characterizes additional resistance genes such as aac(6')-Ib, aac(6')-Ib-cr, aph(3')-I, strB, qnrB, tetA, catA1, and catB4, which contribute to resistance against aminoglycosides, fluoroquinolones, tetracycline, and chloramphenicol.
Molecular characterization of a multidrug resistance IncF plasmid from the globally disseminated Escherichia coli ST131 clone.
The study identifies multiple antibiotic resistance genes on the IncF plasmid pEC958 from E. coli ST131, including blaCTX-M-15, aac(6')-Ib-cr, blaOXA-1, catB4, mph(A), dfrA17, aadA5, sulI, and tet(A). These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, chloramphenicol, macrolides, trimethoprim, sulfamethoxazole, and tetracycline.
Carriage of Extended-Spectrum Beta-Lactamase-Plasmids Does Not Reduce Fitness but Enhances Virulence in Some Strains of Pandemic E. coli Lineages.
The study found that ESBL-plasmid carriage does not reduce fitness but enhances virulence in some strains of pandemic E. coli lineages. It identified several AMR genes on the ESBL-plasmids, including beta-lactamases (blaCTX-M-15, blaCTX-M-27, blaCTX-M-14), tetracycline resistance genes (tetA, tetR), aminoglycoside resistance genes (aadA, aac(6')-Ib-cr), chloramphenicol resistance gene (catB4), sulfonamide resistance gene (sul2), streptomycin resistance genes (strA, strB), dihydrofolate reductase genes (dhfrVII, dfrA17), and aminoglycoside phosphotransferase gene (aph(3')-Ia). Non-antibiotic resistance genes such as finO, traT, icc, yfaX, yihA, and hha were also identified.
SSTAR, a Stand-Alone Easy-To-Use Antimicrobial Resistance Gene Predictor.
The study presents SSTAR, a software tool for identifying antimicrobial resistance (AR) genes from whole-genome sequencing data. It detects known AR genes and potential new variants, including truncated forms. The tool was applied to analyze resistance genes in Klebsiella pneumoniae ST437 and Escherichia coli ST44, revealing various beta-lactamases, aminoglycoside resistance genes, and porin mutations contributing to resistance.
Diversity, Virulence, and Antimicrobial Resistance in Isolates From the Newly Emerging Klebsiella pneumoniae ST101 Lineage.
The study characterizes the antimicrobial resistance genes and mutations in the emerging Klebsiella pneumoniae ST101 lineage, highlighting the presence of multiple resistance mechanisms including carbapenemases, extended-spectrum beta-lactamases, and various other resistance genes.
Commonality of Multidrug-Resistant Klebsiella pneumoniae ST348 Isolates in Horses and Humans in Portugal.
Evaluating the genome and resistome of extensively drug-resistant Klebsiella pneumoniae using native DNA and RNA Nanopore sequencing.
The study identified multiple AMR genes in extensively drug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (blaSHV-11, blaTEM-1B, blaVEB-1, blaOXA-10, blaKPC-2, blaOXA-9, blaVIM-27, blaCTX-M-15, blaOXA-1, blaOXA-48), aminoglycoside resistance genes (aadA1, ant(2'')-Ia, aph(6)-Id, arr-2, aadA24, aph(3')-Ia, aph(6)-Id, aac(3)-IIa, aac(6')Ib-cr, aac(6')-Ib, aac(6')-Ib-cr), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet(A), tet(G)), trimethoprim resistance genes (dfrA1, dfrA14, dfrA23), chloramphenicol resistance genes (cmlA1, catB4), and others.
On-Farm Anaerobic Digestion of Dairy Manure Reduces the Abundance of Antibiotic Resistance-Associated Gene Targets and the Potential for Plasmid Transfer.
The study found that anaerobic digestion of dairy manure significantly reduced the abundance of antibiotic resistance genes, including various ESBL genes such as bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, and bla PER-1, as well as other resistance genes like aac(6')-Ib-cr, aph(3')-Ib, aph(6)-Id, bla OXA-1, catB4, dfrA1, floR, lnu(G), sul2, aadA2, mph(E), msr(E), tet(C), tet(E), and tet(X).
Infective endocarditis caused by Enterobacteriaceae: phenotypic and molecular characterization of Escherichia coli and Klebsiella pneumoniae in Rio de Janeiro, Brazil.
The study identified several AMR genes in E. coli and K. pneumoniae isolates causing infective endocarditis, including genes conferring resistance to beta-lactams, aminoglycosides, sulfonamides, trimethoprim, fosfomycin, and fluoroquinolones. These genes were detected through molecular analysis and resistance profiling.
Clinical Efficacy, Antibiotic Resistance Genes, Virulence Factors and Outcome of Hospital-Acquired Pneumonia Induced by Klebsiella pneumoniae Carbapenemase 2-Producing with Tigecycline Treatment in the ICU.
The study identified several antibiotic resistance genes, including blaKPC-2, blaSHV, blaCTX-M, blaTEM, and aac3iia, which are associated with resistance to various antibiotics. Additionally, virulence factors such as AREO-iutA and Capsule-wzc were found to be independently associated with mortality in patients with KPC-KP infections.
Identification of KPC-112 from an ST15 Klebsiella pneumoniae Strain Conferring Resistance to Ceftazidime-Avibactam.
The study identifies a novel KPC variant, KPC-112, which confers resistance to ceftazidime-avibactam. Additionally, various other resistance genes and mutations were characterized, contributing to multidrug resistance in the isolate.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
Investigation of multidrug-resistant plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates from Pakistan.
The study identified 34 antimicrobial resistance genes (ARGs) in multidrug-resistant (MDR) plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates in Pakistan, including bla NDM-1, bla OXA-48, and various beta-lactamases, aminoglycoside resistance genes, and others.
Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase-producing Enterobacterales.
The study identifies catA1, catA2, catB3, catB4, cmlA1, and floR as functional chloramphenicol resistance genes, while catB4 is a non-functional variant due to IS 26-mediated truncation. IS 5 insertion into the catA1 promoter and IS 26-mediated deletion of catB3 lead to reduced or absent chloramphenicol resistance.
Carbapenem-Resistant, Virulence Plasmid-Harboring Klebsiella pneumoniae, United States.
The study identifies six pVir-CRKP isolates from the United States, highlighting their multidrug resistance and enhanced virulence traits. These isolates exhibit resistance to various antibiotics, including carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, due to the presence of specific AMR genes and mutations.
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
The study identified multiple antibiotic resistance genes and mutations in E. coli isolates from intensive pig farming in South Africa, highlighting the spread of resistance across the pork production continuum.
Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.
The study identifies 42 antimicrobial resistance (AMR) genes in the pan-drug resistant Klebsiella pneumoniae isolate KPNW, including beta-lactamases (bla CTX-M-15, bla NDM-1, bla OXA-1, bla TEM-63, bla TEM-104, bla SHV-28), tetracycline resistance genes (tet(A)), and efflux pump genes (oqxA, oqxB, marA, marR, ompK37, pbp3, crp, h-ns, kpnG, kpnH, parC, rsmA). Additionally, the isolate shows resistance to polymyxin B and colistin through modifications in lipid A (eptB, arnT, lptD, msbA, vanG) and other mechanisms.
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