Browse AMR Genes

Explore antimicrobial resistance genes from the literature

cdr20291_2456

two-component regulatory system sensor kinase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to cdr20291_2456

Browse AMR rules for cdr20291_2456

Overview

Drug Classes: daptomycin
Organisms: Clostridioides difficile
Papers: 1
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A689V	-	-	Clostridioides difficile	daptomycin	Reslit	Candidate
E120*	-	-	Clostridioides difficile	daptomycin	Reslit	Candidate

Papers1

1

Identification of Clostridioides difficile mutants with increased daptomycin resistance.

PMID 38376203 · 2024

Mutation Information

cdr20291_2456: p.A689V cdr20291_2456: p.E120*

Protein Change: A689V, E120*
Organisms: Clostridioides difficile
Confers Resistance To: daptomycin
Validation Method: whole-genome sequencing and functional validation
Source Database: Reslit