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cecR

transcriptional regulator

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to cecR

Browse AMR rules for cecR

Overview

Mechanism: reduces cefepime binding
Drug Classes: cefepime
Organisms: Escherichia coli
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Q126A	C377A	reduces cefepime binding	Escherichia coli	cefepime	Reslit	Candidate

Papers1

1

Molecular basis of antibiotic sensing by the TetR family regulator CecR - a structural perspective.

PMID 41194554 · 2026

Q126 is involved in ligand binding and its mutation reduces cefepime binding

Mutation Information

cecR: p.Q126A / c.C377A

Protein Change: Q126A
Nucleotide Change: C377A
Organisms: Escherichia coli
Confers Resistance To: cefepime
Effect on Function: reduces cefepime binding
Validation Method: spectral shift analysis
Source Database: Reslit