Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Cfr 23S ribosomal RNA methyltransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| cfr(D) | Card Database | 1 | - | Enterococcus faecium | - | - | MG707078.1 | AXY65402.1 |
| Cfr(D) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 12 | STREPTOGRAMIN B, CLINDAMYCIN +15 | Enterococcus faecium +7 | Spain, Korea, China, Hangzhou, China|Hangzhou City | 2020, 2021, 2022, 2023, 2024, 2025 | MG707078.1 | AXY65402.1 |
| cfrD | Reslit | 2 | linezolid, streptogramin a +3 | Enterococcus faecalis +1 | Spain | 2023, 2024 | PRJEB62654|OR069652 | - |
| cfr (D) | Reslit | 1 | linezolid | Enterococcus faecium | Pakistan | 2024 | PRJNA1013219 | - |
Molecular and functional analysis of the novel cfr(D) linezolid resistance gene identified in Enterococcus faecium.
Molecular and functional analysis of the novel cfr(D) linezolid resistance gene identified in Enterococcus faecium.
Molecular and functional analysis of the novel cfr(D) linezolid resistance gene identified in Enterococcus faecium.
Mechanisms of Linezolid Resistance Among Enterococci of Clinical Origin in Spain-Detection of optrA- and cfr(D)-Carrying E. faecalis.
The study identifies optrA and cfr(D) as the primary mechanisms of linezolid resistance in Enterococcus faecalis and E. faecium, with optrA being prevalent and cfr(D) reported for the first time in E. faecalis. Additionally, a G2576T mutation in 23S rDNA was found in E. faecium isolates.
Prevalence and Characteristics of Phenicol-Oxazolidinone Resistance Genes in Enterococcus Faecalis and Enterococcus Faecium Isolated from Food-Producing Animals and Meat in Korea.
The study identified optrA, poxtA, fexA, and cfr(D) genes in Enterococcus faecalis and Enterococcus faecium isolates from food-producing animals and meat in Korea, highlighting their role in phenicol-oxazolidinone resistance and horizontal gene transfer.
Persistence of transferable oxazolidinone resistance genes in enterococcal isolates from a swine farm in China.
The study identified the persistence of transferable oxazolidinone resistance genes, particularly optrA, poxtA, and cfr(D), in enterococcal isolates from a swine farm in China. These genes were found to confer resistance to linezolid, tedizolid, chloramphenicol, and florfenicol.
Nasotracheal enterococcal carriage and resistomes: detection of optrA-, poxtA- and cfrD-carrying strains in migratory birds, livestock, pets, and in-contact humans in Spain.
The study identifies optrA, poxtA, and cfrD genes in Enterococcus isolates from pigs, dogs, storks, and pig-farmers, indicating the presence of linezolid-resistant enterococci in various hosts, emphasizing the need for monitoring through a One-Health approach.
Linezolid-Resistant Enterococcus faecalis of Chicken Origin Harbored Chromosome-Borne optrA and Plasmid-Borne cfr, cfr(D), and poxtA2 Genes.
The study identified four acquired linezolid resistance genes (optrA, cfr, cfr(D), and poxtA2) in a linezolid-resistant Enterococcus faecalis isolate from chicken origin. These genes were located on both chromosomal and plasmid DNA, with cfr embedded in a novel pseudocompound transposon. The plasmids carrying these genes were capable of transferring between Enterococcus faecalis and Staphylococcus aureus.
Co-Existence of Oxazolidinone Resistance Genes cfr(D) and optrA on Two Streptococcus parasuis Isolates from Swine.
The study identifies the co-existence of oxazolidinone resistance genes optrA and cfr(D) in two Streptococcus parasuis isolates, highlighting their genetic environments and potential for horizontal transfer.
Mapping the widespread distribution and transmission dynamics of linezolid resistance in humans, animals, and the environment.
The study identified the widespread distribution of linezolid resistance genes optrA, poxtA, cfr, and cfr(D) in various niches, including humans, animals, and the environment. These genes were found to confer resistance to linezolid, chloramphenicol, erythromycin, tetracycline, and penicillin G.
Genomic epidemiology reveals multiple mechanisms of linezolid resistance in clinical enterococci in China.
The study identified optrA as the most common linezolid resistance mechanism in clinical enterococci in China, along with cfr(D) and poxtA. Mutations in rplC and rplD were also associated with linezolid resistance.
Genomic Characterization and Phylogenetic Analysis of Linezolid-Resistant Enterococcus from the Nostrils of Healthy Hosts Identifies Zoonotic Transmission.
The study identifies optrA, poxtA, and cfrD as key genes responsible for linezolid resistance in Enterococcus isolates from healthy hosts, highlighting zoonotic transmission between pigs and pig farmers.
Linezolid-resistant Enterococcus faecium clinical isolates from Pakistan: a genomic analysis.
The study identifies optr A, poxt A, and cfr (D) genes as key determinants of linezolid resistance in Enterococcus faecium isolates from Pakistan, along with G2576T mutations in the 23S rRNA gene.
Emergence of Linezolid Resistance Genes optrA and cfr(D) in an Enterococcus saccharolyticus from Chicken.
The study reports the first identification of optrA and cfr(D) in Enterococcus saccharolyticus from chicken feces in China, highlighting their presence in a new species and emphasizing the need for surveillance of resistance determinants in animal-associated bacteria.
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