chp2

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putative chaperone

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to chp2

AMR Rules

Browse AMR rules for chp2

Validation StatusCandidate

Overview

Mechanism: mutation in the gene leads to resistance to ethionamide
Validation Method: machine learning and structural analysis
Drug Classes: ethionamide, rifampicin
Organisms: Mycobacterium tuberculosis, Mycobacterium bovis BCG
Geographic Location: Belarus|South Africa|South Korea|India
Papers: 2
Databases: Reslit

Papers2

Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance.

PMID 30333483 · 2018

The study identifies 33 known AMR genes and 24 new genetic signatures of AMR in Mycobacterium tuberculosis using machine learning and structural analysis. It also reveals 97 epistatic interactions across 10 resistance classes and provides mechanistic insights into the selection of these genes.

Gene Information

Gene Name: chp2
Allele: chp2
Encodes: putative chaperone
Source Database: Reslit
Mechanism: mutation in the gene leads to resistance to ethionamide
Confers Resistance To: ethionamide
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Belarus|South Africa|South Korea|India
Validation Method: machine learning and structural analysis

Identification of gene targets that potentiate the action of rifampicin on Mycobacterium bovis BCG.

PMID 39150447 · 2024

The study identified genes involved in cell wall synthesis, transport, and signaling pathways that contribute to rifampicin resistance in Mycobacterium bovis BCG. Key genes include chp2, pknE, thrE, fabD, iniB, and mce1R, which were found to enhance susceptibility when mutated.