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cinA

putative competence-damage inducible protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to cinA

Browse AMR rules for cinA

Validation StatusCandidate

Overview

Mechanism: mediates drug tolerance via cleavage of NAD-drug adducts
Validation Method: qRT-PCR analysis
Drug Classes: tylosin, isoniazid, ethionamide, delamanid, pretomanid
Organisms: Streptococcus suis ATCC 700794, Mycobacterium tuberculosis
Papers: 2
Databases: Reslit

Papers2

1

Analysis of multidrug resistance in Streptococcus suis ATCC 700794 under tylosin stress.

PMID 31874073 · 2019

The study identified differentially expressed proteins including elongation factors (fusA, tuf, tsf), GrpE (grpE), and TCS components (cinA, comD) in tylosin-resistant Streptococcus suis ATCC 700794, suggesting their involvement in tylosin resistance mechanisms.

Gene Information

Gene Name: cinA
Allele: cinA
Encodes: putative competence-damage inducible protein
Source Database: Reslit
Confers Resistance To: tylosin
Organisms Tested In: • Streptococcus suis ATCC 700794
Validation Method: qRT-PCR analysis

2

CinA mediates multidrug tolerance in Mycobacterium tuberculosis.

PMID 35459278 · 2022

CinA mediates tolerance to isoniazid, ethionamide, delamanid, and pretomanid in Mycobacterium tuberculosis through cleavage of NAD-drug adducts.

Gene Information

Gene Name: cinA
Allele: cinA
Encodes: deamidase and pyrophosphatase
Source Database: Reslit
Mechanism: mediates drug tolerance via cleavage of NAD-drug adducts
Confers Resistance To: isoniazidethionamidedelamanidpretomanid
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: genetic inactivation and complementation studies

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