Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ATP-dependent ATPase involved in protein degradation
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G99D | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| V63A | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| K209E | - | impairs PanD degradation | Mycobacterium tuberculosis, Mycobacterium bovis | pyrazinamide | Reslit | Candidate |
| G258V | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Candidate |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
Mutation in clpC1 encoding an ATP-dependent ATPase involved in protein degradation is associated with pyrazinamide resistance in Mycobacterium tuberculosis.
A single mutation in the clpC1 gene (G296T, resulting in G99D) was identified as a potential new mechanism of pyrazinamide resistance in Mycobacterium tuberculosis, in addition to known resistance genes pncA, rpsA, and panD.
Atypical Genetic Basis of Pyrazinamide Resistance in Monoresistant Mycobacterium tuberculosis.
Overcoming the Challenges of Pyrazinamide Susceptibility Testing in Clinical Mycobacterium tuberculosis Isolates.
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