Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
proteolytic regulatory protein
Overview
walK and clpP mutations confer reduced vancomycin susceptibility in Staphylococcus aureus.
The study identifies walK and clpP mutations as contributing to reduced vancomycin susceptibility in Staphylococcus aureus, demonstrating that these mutations lead to increased vancomycin MIC when introduced into a susceptible strain.
A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology.
Inactivation of the ClpP protease in Staphylococcus aureus leads to reduced susceptibility to daptomycin, vancomycin, and oxacillin. A single nucleotide polymorphism (SNP) in the clpP gene (G281A) results in a G94D amino acid substitution, which inactivates ClpP and confers resistance. Additionally, a SNP in the rpoB gene (C1430A) leads to an A477D substitution, which confers resistance to rifampin.
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