Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ATP-dependent protease ClpX
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| P64L | - | - | Staphylococcus aureus | vancomycin|daptomycin|dalbavancin | Reslit | Candidate |
| F241L | - | - | Staphylococcus aureus | ceftaroline | Reslit | Candidate |
| E356V | - | - | Staphylococcus aureus | ceftaroline | Reslit | Candidate |
| G278* | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| G98* | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
Comprehensive identification of single nucleotide polymorphisms associated with beta-lactam resistance within pneumococcal mosaic genes.
The study identifies 51 loci, including 301 SNPs, associated with beta-lactam non-susceptibility in Streptococcus pneumoniae, focusing on genes involved in peptidoglycan biosynthesis and other pathways.
Deciphering the distance to antibiotic resistance for the pneumococcus using genome sequencing data.
The study identifies numerous genes and mutations associated with antibiotic resistance in Streptococcus pneumoniae through genome-wide association studies, highlighting the genetic basis of resistance to penicillin, trimethoprim, cotrimoxazole, erythromycin, and fluoroquinolones.
Loss of the ClpXP Protease Leads to Decreased Resistance to Cell-Envelope Targeting Antimicrobials in Bacillus anthracis Sterne.
The study shows that the ClpXP protease is essential for maintaining resistance to cell-envelope targeting antimicrobials in Bacillus anthracis Sterne. Disruption of clpX, clpP1, or clpP2 leads to increased susceptibility to various antimicrobials, including LL-37, nisin, daptomycin, penicillin, and vancomycin. Both clpP1 and clpP2 contribute to resistance, though the effect of clpX disruption is more pronounced.
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