Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
cardiolipin synthetase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R218Q | single resistance variant, cardiolipin synthase Cls | Enterococcus faecalis, Enterococcus faecium | daptomycin | ReslitCard DatabaseReference Gene Catalog | Candidate | |
| H215R | single resistance variant, cardiolipin synthase Cls | Enterococcus faecium, Enterococcus faecalis | daptomycin | ReslitCard DatabaseReference Gene Catalog | Candidate | |
| S104L | - | - | Enterococcus faecalis | daptomycin | Reslit | Candidate |
| R228H | - | - | Staphylococcus aureus | daptomycin | Reslit | Candidate |
| N13I | single resistance variant, cardiolipin synthase Cls | Enterococcus faecium, Enterococcus faecalis | daptomycin | ReslitCard DatabaseReference Gene Catalog | Candidate | |
| N13S | cardiolipin synthase Cls | Enterococcus faecium | daptomycin | ReslitReference Gene Catalog | Candidate | |
| N13T | single resistance variant, cardiolipin synthase Cls | Enterococcus faecium | daptomycin | ReslitCard DatabaseReference Gene Catalog | Candidate | |
| H270R | - | - | - | daptomycin | Reslit | Candidate |
| K60T | - | - | - | daptomycin | Reslit | Candidate |
| R211Q | increased cardiolipin synthesis activity, cardiolipin synthase Cls | Enterococcus faecium | daptomycin | ReslitReference Gene Catalog | Candidate | |
| A20D | alter phospholipid biosynthesis and decrease bacterial susceptibility, single resistance variant, cardiolipin synthase Cls | Enterococcus faecium | daptomycin | ReslitCard DatabaseReference Gene Catalog | Candidate | |
| I269T | - | - | Enterococcus faecium, Enterococcus faecalis | daptomycin | Reslit | Candidate |
| I203V | - | - | Enterococcus faecium, Enterococcus faecalis | daptomycin | Reslit | Candidate |
| S298T | - | - | Enterococcus faecium, Enterococcus faecalis | daptomycin | Reslit | Candidate |
| D13I | - | - | Enterococcus faecium | daptomycin | Reslit | Candidate |
| R267H | - | single resistance variant, cardiolipin synthase Cls | Enterococcus faecalis, Enterococcus faecium | daptomycin | Card DatabaseReference Gene Catalog | Candidate |
| D27N | - | single resistance variant, cardiolipin synthase Cls | Enterococcus faecium | daptomycin | Card DatabaseReference Gene Catalog | Candidate |
| K59T | - | single resistance variant, cardiolipin synthase Cls | Enterococcus faecium | daptomycin | Card DatabaseReference Gene Catalog | Candidate |
| G177T | - | single resistance variant | Enterococcus faecium | daptomycin | Card Database | Candidate |
| L52F | - | single resistance variant, cardiolipin synthase Cls | Staphylococcus aureus | daptomycin | Card DatabaseReference Gene Catalog | Candidate |
| F60S | - | single resistance variant, cardiolipin synthase Cls | Staphylococcus aureus | daptomycin | Card DatabaseReference Gene Catalog | Candidate |
| A23V | - | single resistance variant, cardiolipin synthase Cls | Staphylococcus aureus | daptomycin | Card DatabaseReference Gene Catalog | Candidate |
| T33N | single resistance variant, cardiolipin synthase Cls | Staphylococcus aureus, Staphylococcus simulans | daptomycin | Card DatabaseReference Gene CatalogReslit | Candidate | |
| NFQ77del | - | cardiolipin synthase Cls | Enterococcus faecalis | daptomycin | Reference Gene Catalog | Candidate |
| - | - | Enterococcus faecalis | daptomycin | Reslit | Candidate | |
| - | - | Enterococcus faecalis | daptomycin | Reslit | Candidate | |
| I432V | - | - | daptomycin | Reslit | Candidate | |
| L38V | - | - | daptomycin | Reslit | Candidate | |
| V37A | - | - | daptomycin | Reslit | Candidate | |
| A20P | - | - | daptomycin | Reslit | Candidate | |
| R267S | - | - | daptomycin | Reslit | Candidate | |
| V173G | - | - | daptomycin | Reslit | Candidate |
Genetic basis for in vivo daptomycin resistance in enterococci.
Mutations in the genes encoding LiaF and a GdpD-family protein were necessary and sufficient for the development of resistance to daptomycin in Enterococcus faecalis. Additionally, an Arg218 Gln substitution in the Cls enzyme was found in daptomycin-resistant E. faecium isolates.
Adaptation of Enterococcus faecalis to daptomycin reveals an ordered progression to resistance.
The study identified mutations in the liaF, liaR, yvlB, and cls genes that contribute to daptomycin resistance in Enterococcus faecalis through a defined evolutionary pathway involving the LiaFSR signaling pathway and changes in membrane composition.
Genomic insights into the pathogenicity and environmental adaptability of Enterococcus hirae R17 isolated from pork offered for retail sale.
The study identified multiple antimicrobial resistance genes in Enterococcus hirae R17, including genes conferring resistance to beta-lactam antibiotics, lincosamides, streptogramins, pleuromutilins, polymyxins, tetracyclines, and others. Notably, the strain exhibited resistance to bacitracin, ciprofloxacin, daptomycin, erythromycin, and tetracycline.
New Mutations in cls Lead to Daptomycin Resistance in a Clinical Vancomycin- and Daptomycin-Resistant Enterococcus faecium Strain.
The study identifies new mutations in the cls gene that confer daptomycin resistance in Enterococcus faecium EF332. Additionally, the vanA and vanM genes were found to contribute to vancomycin resistance.
Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.
The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.
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