Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
resistance-nodulation-cell division (RND) antibiotic efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| I136L | - | - | Campylobacter coli, Campylobacter jejuni | florfenicol|ciprofloxacin | Reslit | Candidate |
| I136A | - | - | Campylobacter jejuni | fluoroquinolones|macrolides|tetracycline | Reslit | Candidate |
| F610A | - | - | Campylobacter jejuni | fluoroquinolones|macrolides|tetracycline | Reslit | Candidate |
| F625A | - | - | Campylobacter jejuni | fluoroquinolones|macrolides|tetracycline | Reslit | Candidate |
| L607E | - | - | Campylobacter jejuni | fluoroquinolones|macrolides|tetracycline | Reslit | Candidate |
| L612E | - | - | Campylobacter jejuni | fluoroquinolones|macrolides|tetracycline | Reslit | Candidate |
| L662E | - | - | Campylobacter jejuni | fluoroquinolones|macrolides|tetracycline | Reslit | Candidate |
| K45E | - | Efflux | Campylobacter jejuni | ertapenem|meropenem | ResFinder Database | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| cmeB | Card DatabaseReference Gene CatalogReslit | 22 | macrolides, tetracycline +15 | Campylobacter jejuni subsp. doylei 269.97 +5 | Tanzania, Japan, South Africa, Italy, Cairo, Egypt|Egypt, Tunisia, China, Iran, North of Tunisia, Kenya, Greece, Brazil, Romania | 2007, 2016, 2017, 2018, 2020, 2021, 2022, 2023, 2024, 2025 | CP000768.1 | ABS43151.1 |
| cme B | Reslit | 1 | ciprofloxacin, erythromycin | Campylobacter coli | Ghana | 2020 | - | - |
Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni.
The CmeABC efflux pump contributes to macrolide and tetracycline resistance in Campylobacter jejuni. Inactivation of the cmeB gene significantly reduced resistance to these antibiotics.
Antimicrobial Resistance Mechanisms in Salmonella and Other Bacteria
The paper discusses multidrug efflux pumps from various bacterial food pathogens including Enterobacteriaceae, Vibrio cholerae, and Staphylococcus aureus, highlighting their role in multidrug resistance.
Prevalence and Antimicrobial Resistance of Campylobacter Isolated from Dressed Beef Carcasses and Raw Milk in Tanzania.
The study identified blaOXA-61, cmeB, tet(O), and aph-3-1 as the primary antimicrobial resistance genes in Campylobacter isolates from raw milk and beef carcasses in Tanzania.
Emergence of a Potent Multidrug Efflux Pump Variant That Enhances Campylobacter Resistance to Multiple Antibiotics.
Genomic insights of Pannonibacter phragmitetus strain 31801 isolated from a patient with a liver abscess.
The study identified a β-lactam resistance gene, NPS β-lactamase, and several multidrug resistance efflux pump genes, including acrB, cmeB, macA, and macB, in Pannonibacter phragmitetus strain 31801, which contributes to its resistance to various antibiotics.
Mutations in Genes Encoding Penicillin-Binding Proteins and Efflux Pumps Play a Role in β-Lactam Resistance in Helicobacter cinaedi.
Mutations in pbpA and ftsI genes were identified as key determinants of β-lactam resistance in Helicobacter cinaedi, with pbpA mutations being the primary factor. Additionally, efflux pump components cmeB and cmeD were found to contribute to resistance.
Characterisation of Campylobacter spp. Isolated from Poultry in KwaZulu-Natal, South Africa.
The study identified the gyrA mutation (Thr-86-Ile), tet(O) gene, and cmeB gene as contributors to antibiotic resistance in Campylobacter spp. isolates from poultry in KwaZulu-Natal, South Africa.
Characterization of Campylobacter associated gastric enteritis among patients with Human Immunodeficiency Virus (HIV) in a hospital in Accra, Ghana.
The study identified Campylobacter coli isolates resistant to multiple antibiotics, including tetracycline, ciprofloxacin, and erythromycin, with the presence of resistance genes bla OXA-61, cme B, tet (O), and aad E.
Genotyping and Antibiotic Resistance Traits in Campylobacter jejuni and coli From Pigs and Wild Boars in Italy.
The study identified various AMR genes and mutations in Campylobacter isolates from pigs and wild boars in Italy, highlighting high levels of resistance to tetracycline, ciprofloxacin, nalidixic acid, and erythromycin. Key findings include the detection of tet(O), cmeA, cmeB, cmeC, cmeR, OXA-61, and aph(3')-III genes, as well as the gyrA T86I mutation and 23S rRNA A2075G mutation.
Occurrence, Antimicrobial Resistance, and Molecular Characterization of Campylobacter spp. in Intensive Pig Production in South Africa.
The study identified tetracycline resistance gene tetO, ampicillin resistance gene blaOXA-61, and multidrug efflux pump gene cmeB in Campylobacter spp. Additionally, mutations in gyrA (Thr-86-Ile) and 23S rRNA (A2075G and A2074C) were found to confer resistance to quinolones and erythromycin, respectively.
High-throughput sequencing reveals genetic determinants associated with antibiotic resistance in Campylobacter spp. from farm-to-fork.
The study identified several AMR genes and mutations associated with resistance to quinolones, tetracyclines, and macrolides in Campylobacter isolates from various sources. Key findings include the prevalence of blaOXA-61, tet(O), and mutations in gyrA and 23S rRNA genes.
Virulence Profiling, Multidrug Resistance and Molecular Mechanisms of Campylobacter Strains from Chicken Carcasses in Tunisia.
The study identified multiple AMR genes and mutations in Campylobacter strains from chicken carcasses in Tunisia, highlighting the presence of multidrug-resistant strains with high resistance rates to various antibiotics.
Dysgonomonas mossii Strain Shenzhen WH 0221, a New Member of the Genus Dysgonomonas Isolated from the Blood of a Patient with Diabetic Nephropathy, Exhibits Multiple Antibiotic Resistance.
The study identifies Dysgonomonas mossii strain Shenzhen WH 0221, which exhibits resistance to multiple antibiotics, including cephalosporins, aminoglycosides, beta-lactams, fluoroquinolones, glycopeptides, and phenicols. The resistance is attributed to genes such as kdpE, ykkD, cmeB, TLA-3, and vanRM.
Prevalence, antimicrobial resistance, virulence gene profile and molecular typing of Campylobacter species isolated from poultry meat samples.
The study identified several AMR genes, including aadE1, blaOXA-61, tet(O), and cmeB, in Campylobacter jejuni and C. coli isolates from poultry meat samples. These genes conferred resistance to various antibiotics such as erythromycin, ampicillin, ciprofloxacin, chloramphenicol, and tetracycline.
Relationships between Virulence Genes and Antibiotic Resistance Phenotypes/Genotypes in Campylobacter spp. Isolated from Layer Hens and Eggs in the North of Tunisia: Statistical and Computational Insights.
The study identified several AMR genes and mutations in Campylobacter isolates from layer hens and eggs in Tunisia, including tet(O), cmeB, erm(B), blaOXA-61, and mutations in gyrA and 23S rRNA. These genes and mutations were associated with resistance to tetracycline, fluoroquinolones, macrolides, and beta-lactams.
Campylobacter spp. isolated from poultry in Iran: Antibiotic resistance profiles, virulence genes, and molecular mechanisms.
The study identified blaOXA-61, tet(O), aadE1, aphA-3-1, and cmeB as key AMR genes in Campylobacter isolates from poultry in Iran, highlighting their role in resistance to beta-lactams, tetracyclines, aminoglycosides, and fluoroquinolones.
Antimicrobial Usage, Susceptibility Profiles, and Resistance Genes in Campylobacter Isolated from Cattle, Chicken, and Water Samples in Kajiado County, Kenya.
The study identified several AMR genes in Campylobacter isolates, including tet(O), blaOXA-61, aph-3-1, gyrA, and cmeB, which confer resistance to tetracycline, ampicillin, gentamicin, ciprofloxacin, and multiple antibiotics. High levels of multidrug resistance were observed, highlighting the urgent need for improved antimicrobial stewardship.
Persistence of Campylobacter spp. in Poultry Flocks after Disinfection, Virulence, and Antimicrobial Resistance Traits of Recovered Isolates.
The study identified the presence of AMR genes such as bla OXA-61, cmeB, and tet(O) in Campylobacter isolates, along with mutations in gyrA and 23S rRNA genes that contribute to resistance against various antibiotics.
Overview of Ecology and Aspects of Antibiotic Resistance in Campylobacter spp. Isolated from Free-Grazing Chicken Tissues in Rural Households.
The study identified several AMR genes and mutations in Campylobacter spp. isolated from free-grazing chickens, including blaOxA-61, tet(O), tet(A), cmeA, cmeB, cmeC, and a Thr-86-Ile mutation in gyrA, contributing to multidrug resistance.
Insights on the genomic diversity, virulence and resistance profile of a Campylobacter jejuni strain isolated from a hospitalized patient in Brazil.
The study identified the presence of the blaOXA-605 gene, cmeB gene, and a T86I mutation in the QRDR region of gyrA in a Campylobacter jejuni strain, which conferred resistance to beta-lactam, tetracycline, and quinolone antibiotics.
Mutation-based mechanism and evolution of the potent multidrug efflux pump RE-CmeABC in Campylobacter.
Genotypic and Phenotypic Characterization of Antimicrobial Resistance and Virulence in Campylobacter spp. Isolated from Turkeys: Uncovering a Neglected Reservoir in the One Health Context.
The study identified several antimicrobial resistance genes, including tetO, gyrA (Thr-86-Ile mutation), ermB, Ery23S (A2075G mutation), and cmeB, in Campylobacter jejuni and C. coli isolates from turkeys, highlighting the presence of multidrug resistance and virulence factors.
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