cmeD

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efflux pump component

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to cmeD

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: knocking out cmeB and cmeD
Drug Classes: amoxicillin, ceftriaxone
Organisms: Helicobacter cinaedi
Geographic Location: Japan
Papers: 1
Databases: Reslit

Papers1

Mutations in Genes Encoding Penicillin-Binding Proteins and Efflux Pumps Play a Role in β-Lactam Resistance in Helicobacter cinaedi.

PMID 29203490 · 2018

Mutations in pbpA and ftsI genes were identified as key determinants of β-lactam resistance in Helicobacter cinaedi, with pbpA mutations being the primary factor. Additionally, efflux pump components cmeB and cmeD were found to contribute to resistance.

Gene Information

Gene Name: cmeD
Allele: cmeD
Encodes: efflux pump component
Source Database: Reslit
Confers Resistance To: amoxicillinceftriaxone
Organisms Tested In: • Helicobacter cinaedi
Geographic Location: Japan
Validation Method: knocking out cmeB and cmeD
Sequence Accession: AP017374|DRA005701

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cmeD

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cmeD

Gene Information