Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
major facilitator superfamily (MFS) antibiotic efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| A68V | - | AraC family transcriptional regulator CmrA | Pseudomonas aeruginosa | phenicols|imipenem|quinolones | Reference Gene Catalog | Candidate |
| L89Q | - | AraC family transcriptional regulator CmrA | Pseudomonas aeruginosa | phenicols|imipenem|quinolones | Reference Gene Catalog | Candidate |
| H204L | - | AraC family transcriptional regulator CmrA | Pseudomonas aeruginosa | phenicols|imipenem|quinolones | Reference Gene Catalog | Candidate |
| N214K | - | AraC family transcriptional regulator CmrA | Pseudomonas aeruginosa | phenicols|imipenem|quinolones | Reference Gene Catalog | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| cmrA | Card DatabaseResFinder Database | 2 | CHLORAMPHENICOL | Rhodococcus rhodochrous +1 | - | 1992 | AF015087.1 | AAC45805.1 |
| CmrA | Card DatabaseReference Gene CatalogReslit | 5 | CHLORAMPHENICOL, phenicols +2 | Rhodococcoides fascians +2 | - | 1992, 1997, 2017 | Z12001.1 | CAA78046.1 |
| cmr | ResFinder DatabaseReslit | 8 | phenicols, quaternary ammonium compounds +3 | Klebsiella pneumoniae +7 | Kenya, USA|Peru|Egypt|Cambodia|Kenya, Brazil | 1997, 2016, 2017, 2020, 2021, 2022, 2023 | NCBI Accession no. KX377894|KX377894 | - |
The plasmid-encoded chloramphenicol-resistance protein of Rhodococcus fascians is homologous to the transmembrane tetracycline efflux proteins.
The plasmid-encoded chloramphenicol-resistance protein of Rhodococcus fascians is homologous to the transmembrane tetracycline efflux proteins.
The plasmid-encoded chloramphenicol-resistance protein of Rhodococcus fascians is homologous to the transmembrane tetracycline efflux proteins.
Toxic Electrophiles Induce Expression of the Multidrug Efflux Pump MexEF-OprN in Pseudomonas aeruginosa through a Novel Transcriptional Regulator, CmrA.
The study identifies CmrA as a novel transcriptional regulator that induces the expression of the multidrug efflux pump MexEF-OprN in Pseudomonas aeruginosa in response to electrophilic stress. It also characterizes PA2048, a quinol monooxygenase, as a key component in the activation of the efflux pump.
Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.
The study identified 46 AMR genes or gene families in 90 Klebsiella pneumoniae isolates from Kenya, highlighting the prevalence of multidrug resistance and the diversity of resistance mechanisms.
Comparison of antimicrobial resistant genes in chicken gut microbiome grown on organic and conventional diet.
The study identified various antimicrobial resistance genes in the gut microbiome of chickens raised on organic and conventional diets, including beta-lactamases, multidrug efflux systems, aminoglycoside modifying enzymes, and tetracycline resistance genes. These genes were found to be more prevalent in conventional diet samples under higher antibiotic concentrations.
Tracking Antimicrobial Resistance Determinants in Diarrheal Pathogens: A Cross-Institutional Pilot Study.
The study identified 55 different antimicrobial resistance determinants in diarrheal pathogens, highlighting the presence of genes conferring resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, macrolides, tetracyclines, phenicols, sulfonamides, and others. Notably, carbapenemase genes like bla OXA-48 and bla NDM were detected in certain isolates, indicating emerging resistance concerns.
Endophytic Lifestyle of Global Clones of Extended-Spectrum β-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?
The study identifies multiple AMR genes in endophytic ESBL-producing Enterobacterales isolated from fresh vegetables, highlighting their potential role in the spread of antibiotic resistance.
Analysis of the Oxidative Stress Regulon Identifies soxS as a Genetic Target for Resistance Reversal in Multidrug-Resistant Klebsiella pneumoniae.
The study identifies that the soxS gene regulates antimicrobial resistance in multidrug-resistant Klebsiella pneumoniae MGH78578, particularly affecting tetracycline resistance through the regulation of efflux pumps like acrAB-tolC and others.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Propidium Monoazide-Treated, Cell-Direct, Quantitative PCR for Detecting Viable Chloramphenicol-Resistant Escherichia coli and Corynebacterium glutamicum Cells.
The study developed a PMA-qPCR method to detect viable chloramphenicol-resistant E. coli and C. glutamicum cells, targeting the CmR gene.
A Corynebacterium glutamicum gene conferring multidrug resistance in the heterologous host Escherichia coli.
Transposition of the IS21-related element IS1415 in Rhodococcus erythropolis.
Transposition of the IS21-related element IS1415 in Rhodococcus erythropolis.
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