cph

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capreomycin phosphotransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to cph

AMR Rules

Browse AMR rules for cph

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: disk diffusion assay, enzyme activity assay
Drug Classes: VIOMYCIN, CAPREOMYCIN, capreomycin
Organisms: Saccharothrix mutabilis subsp. capreolus, Streptosporangium roseum, Streptomyces sp. SID8364, Streptomyces filamentosus NRRL15998, Escherichia coli
Papers: 2
Databases: Card DatabaseReference Gene CatalogReslit

Papers2

Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin.

PMID 34994196 · 2022

Gene Information

Gene Name: cph
Allele: cph
Encodes: capreomycin phosphotransferase
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: VIOMYCINCAPREOMYCIN
Organisms Tested In: • Saccharothrix mutabilis subsp. capreolus
Sequence Accession: U13078.1
Protein Accession: AAA92037.1
Notes: ARO:3007075

Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin.

PMID 34994196 · 2022

Gene Information

Gene Name: cph
Allele: cph
Encodes: capreomycin phosphotransferase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: VIOMYCINCAPREOMYCIN
Organisms Tested In: • Saccharothrix mutabilis subsp. capreolus
Sequence Accession: U13078.1
Protein Accession: AAA92037.1
Notes: ARO:3007075

Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin.

PMID 38114770 · 2023

The study identified and characterized cph homologs, particularly cph001, which confer resistance to capreomycin (CMN) and viomycin (VIO) by phosphorylating these antibiotics.

Gene Information

Gene Name: cph
Allele: cph
Encodes: phosphotransferase
Source Database: Reslit
Mechanism: resistance to capreomycin by phosphorylation of the hydroxyl group of CMN IIA
Confers Resistance To: capreomycin
Organisms Tested In: • Streptosporangium roseum
• Streptomyces sp. SID8364
• Streptomyces filamentosus NRRL15998
• Escherichia coli
Validation Method: disk diffusion assay, enzyme activity assay
Sequence Accession: WP_012891209|MYT78782|EWS93654

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cph

View on PubMed

capreomycin phosphotransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to cph

AMR Rules

Browse AMR rules for cph

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: disk diffusion assay, enzyme activity assay
Drug Classes: VIOMYCIN, CAPREOMYCIN, capreomycin
Organisms: Saccharothrix mutabilis subsp. capreolus, Streptosporangium roseum, Streptomyces sp. SID8364, Streptomyces filamentosus NRRL15998, Escherichia coli
Papers: 2
Databases: Card DatabaseReference Gene CatalogReslit

Papers2

Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin.

PMID 34994196 · 2022

Gene Information

Gene Name: cph
Allele: cph
Encodes: capreomycin phosphotransferase
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: VIOMYCINCAPREOMYCIN
Organisms Tested In: • Saccharothrix mutabilis subsp. capreolus
Sequence Accession: U13078.1
Protein Accession: AAA92037.1
Notes: ARO:3007075

Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin.

PMID 34994196 · 2022

Gene Information

Gene Name: cph
Allele: cph
Encodes: capreomycin phosphotransferase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: VIOMYCINCAPREOMYCIN
Organisms Tested In: • Saccharothrix mutabilis subsp. capreolus
Sequence Accession: U13078.1
Protein Accession: AAA92037.1
Notes: ARO:3007075

Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin.

PMID 38114770 · 2023

The study identified and characterized cph homologs, particularly cph001, which confer resistance to capreomycin (CMN) and viomycin (VIO) by phosphorylating these antibiotics.

Gene Information

Gene Name: cph
Allele: cph
Encodes: phosphotransferase
Source Database: Reslit
Mechanism: resistance to capreomycin by phosphorylation of the hydroxyl group of CMN IIA
Confers Resistance To: capreomycin
Organisms Tested In: • Streptosporangium roseum
• Streptomyces sp. SID8364
• Streptomyces filamentosus NRRL15998
• Escherichia coli
Validation Method: disk diffusion assay, enzyme activity assay
Sequence Accession: WP_012891209|MYT78782|EWS93654

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cph

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cph

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