cphA2

CphA beta-lactamase

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: Gene presence confirmed via whole genome sequencing and association with AMR profiles
Drug Classes: ampicillin, cefoxitin, cefotaxime, cefpodoxime, ceftriaxone, penicillin
Organisms: Aeromonas hydrophila, Aeromonas dhakensis, Aeromonas veronii
Geographic Location: Karachi, Pakistan
Papers: 1
Databases: Card DatabaseReslit

Papers1

Gene Information

Gene Name: cphA2
Allele: cphA2
Encodes: CphA beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Aeromonas hydrophila
Sequence Accession: U60294.1
Protein Accession: AAB03413.1
Notes: ARO:3003099

Genomic analysis of clinical Aeromonas isolates reveals genetic diversity but little evidence of genetic determinants for diarrhoeal disease.

PMID 38451244 · 2024

The study identifies a high prevalence of antimicrobial resistance (AMR) genes in Aeromonas isolates from children with moderate-to-severe diarrhea (MSD) in Karachi, Pakistan. Key AMR genes include beta-lactamases (blaCMY-1, oxa-12, cphA2, mox), sulfonamide resistance (sul1), aminoglycoside resistance (aac(6')-lld), and tetracycline resistance (tetE).

Gene Information

Gene Name: cphA2
Allele: cphA2
Encodes: Beta-lactamase
Source Database: Reslit
Mechanism: Hydrolysis of beta-lactam antibiotics
Confers Resistance To: ampicillincefoxitincefotaximecefpodoximeceftriaxonepenicillin
Organisms Tested In: • Aeromonas dhakensis
• Aeromonas veronii
Geographic Location: Karachi, Pakistan
Validation Method: Gene presence confirmed via whole genome sequencing and association with AMR profiles
Sequence Accession: PRJEB15489|PRJEB1611

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cphA2

CphA beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to cphA2

AMR Rules

Browse AMR rules for cphA2

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: Gene presence confirmed via whole genome sequencing and association with AMR profiles
Drug Classes: ampicillin, cefoxitin, cefotaxime, cefpodoxime, ceftriaxone, penicillin
Organisms: Aeromonas hydrophila, Aeromonas dhakensis, Aeromonas veronii
Geographic Location: Karachi, Pakistan
Papers: 1
Databases: Card DatabaseReslit

Papers1

PMID N/A

Gene Information

Gene Name: cphA2
Allele: cphA2
Encodes: CphA beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Aeromonas hydrophila
Sequence Accession: U60294.1
Protein Accession: AAB03413.1
Notes: ARO:3003099

Genomic analysis of clinical Aeromonas isolates reveals genetic diversity but little evidence of genetic determinants for diarrhoeal disease.

PMID 38451244 · 2024

Gene Information

Gene Name: cphA2
Allele: cphA2
Encodes: Beta-lactamase
Source Database: Reslit
Mechanism: Hydrolysis of beta-lactam antibiotics
Confers Resistance To: ampicillincefoxitincefotaximecefpodoximeceftriaxonepenicillin
Organisms Tested In: • Aeromonas dhakensis
• Aeromonas veronii
Geographic Location: Karachi, Pakistan
Validation Method: Gene presence confirmed via whole genome sequencing and association with AMR profiles
Sequence Accession: PRJEB15489|PRJEB1611

Comments (0)

No comments yet. Be the first to comment!

cphA2

Gene Information

Gene Information

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cphA2

Gene Information

Gene Information