cphA5

CphA beta-lactamase

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: whole genome sequencing
Drug Classes: carbapenems, ampicillin, imipenem
Organisms: Aeromonas salmonicida, Aeromonas spp.
Geographic Location: India, Norway, Stellenbosch, South Africa
Papers: 3
Databases: Card DatabaseReslit

Papers3

Gene Information

Gene Name: cphA5
Allele: cphA5
Encodes: CphA beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Aeromonas salmonicida
Sequence Accession: AY227051.1
Protein Accession: AAP69913.1
Notes: ARO:3003101

Spatiotemporal Investigation of Antibiotic Resistance in the Urban Water Cycle Influenced by Environmental and Anthropogenic Activity.

PMID 36036576 · 2022

The study identified several AMR genes, including carbapenemases (cphA5, cphA7, imiH, ESP-1), colistin resistance gene mcr-7.1, aminoglycoside resistance genes (aadA, aph(6)-Id, aph(3')-Ib), sulfonamide/trimethoprim resistance genes (sul1, dfrA15, dfrA14), and multidrug efflux pumps (MexB, OpmH, MexK) in various bacterial isolates from urban water samples.

Gene Information

Gene Name: cphA5
Allele: cphA5
Encodes: carbapenemase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: carbapenems
Organisms Tested In: • Aeromonas spp.
Geographic Location: Stellenbosch, South Africa
Validation Method: whole genome sequencing

Aeromonas species isolated from aquatic organisms, insects, chicken, and humans in India show similar antimicrobial resistance profiles.

PMID 36532495 · 2022

The study identified multiple antimicrobial resistance (AMR) genes in Aeromonas species isolated from various hosts in India, including beta-lactamases (bla OXA-12, bla OXA-427, bla OXA-724, bla OXA-780, bla FOX-2, bla FOX-4, bla FOX-5, bla FOX-7, bla AQU-2, bla MOX-7), metallo-beta-lactamases (cphA3, cphA4, cphA5, cphA8, ImiH), and other resistance genes (dfrA12, aadA2, ANT(3")-IIa, sul1). Additionally, multidrug efflux pump genes (mdtH, zntA, emrD, blR, crp) were found to contribute to AMR in these isolates.

Gene Information

Gene Name: cphA5
Allele: cphA5
Encodes: Metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Aeromonas salmonicida
Geographic Location: India
Validation Method: whole genome sequencing
Sequence Accession: JAJVCV000000000|JAJVCT000000000|JAJVCU000000000|JAJVCW000000000|JACGXR000000000.1|CP046407.1|ANNT00000000.1|LZFM00000000.1|JZTH00000000.1|JZTG00000000.1|CP022550.1|WVRP00000000.1|CP032839.1|LXJN00000000.1|JZTF00000000.1|JAJVCW000000000.1

Whole genome sequence analysis of Aeromonas spp. isolated from ready-to-eat seafood: antimicrobial resistance and virulence factors.

PMID 37455746 · 2023

The study identified various AMR genes in Aeromonas strains isolated from ready-to-eat seafood, including beta-lactamases (bla OXA-12, bla OXA-780, bla OXA-427, bla OXA-956, cphA1, cphA2, cphA5), quinolone resistance gene qnrS2, sulfonamide resistance gene sul1, aminoglycoside resistance gene aadA1, tetracycline efflux pump tet(E), and efflux pump qacEΔ1.