cplR

ABC-F type ribosomal protection protein CplR

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target protection
Validation Method: expression in B. subtilis ΔvmlR and MIC testing
Drug Classes: RETAPAMULIN, CLINDAMYCIN, LINCOMYCIN, VIRGINIAMYCIN, pleuromutilins, lincosamides, streptogramin a
Organisms: Clostridium sporogenes, Clostridioides difficile 630, Clostridium perfringens str. 13, Clostridium difficile, Clostridium perfringens
Alleles: 4
Papers: 1
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants4

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
CplR	Card DatabaseReference Gene CatalogReslit	5	RETAPAMULIN, CLINDAMYCIN +5	Clostridium sporogenes +3	-	2023	CP009225.1	AKC61310.1
cplR	Card Database	1	-	Clostridioides difficile 630	-	-	CP010905.2	AJP12342.1
Cper_cplR	Card Database	1	-	Clostridium perfringens str. 13	-	-	BA000016.3	BAB80490.1
Cspo_cplR	Card Database	1	-	Clostridium sporogenes	-	-	CP009225.1	AKC61310.1

Papers1

PMID N/A

Gene Information

Gene Name: cplR
Allele: CplR
Encodes: ABC-F type ribosomal protection protein CplR
Source Database: Reference Gene Catalog
Mechanism: antibiotic target protection
Confers Resistance To: RETAPAMULINCLINDAMYCINLINCOMYCINVIRGINIAMYCIN
Organisms Tested In: • Clostridium sporogenes
Sequence Accession: CP009225.1
Protein Accession: AKC61310.1
Notes: ARO:3007645

PMID N/A

Gene Information

Gene Name: cplR
Allele: CplR
Encodes: ABC-F type ribosomal protection protein CplR
Source Database: Card Database
Mechanism: antibiotic target protection
Confers Resistance To: RETAPAMULINCLINDAMYCINLINCOMYCINVIRGINIAMYCIN
Organisms Tested In: • Clostridium sporogenes
Sequence Accession: CP009225.1
Protein Accession: AKC61310.1
Notes: ARO:3007645

PMID N/A

Gene Information

Gene Name: cplR
Allele: CplR
Encodes: ABC-F type ribosomal protection protein CplR
Source Database: Reference Gene Catalog
Mechanism: antibiotic target protection
Confers Resistance To: RETAPAMULINCLINDAMYCINLINCOMYCINVIRGINIAMYCIN
Organisms Tested In: • Clostridioides difficile 630
Sequence Accession: CP010905.2
Protein Accession: AJP12342.1
Notes: ARO:3007637

PMID N/A

Gene Information

Gene Name: cplR
Allele: CplR
Encodes: ABC-F type ribosomal protection protein CplR
Source Database: Card Database
Mechanism: antibiotic target protection
Confers Resistance To: RETAPAMULINCLINDAMYCINLINCOMYCINVIRGINIAMYCIN
Organisms Tested In: • Clostridioides difficile 630
Sequence Accession: CP010905.2
Protein Accession: AJP12342.1
Notes: ARO:3007637

PMID N/A

Gene Information

Gene Name: cplR
Allele: cplR
Encodes: Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins
Source Database: Card Database
Mechanism: antibiotic target protection
Organisms Tested In: • Clostridioides difficile 630
Sequence Accession: CP010905.2
Protein Accession: AJP12342.1
Notes: ARO:3007637

PMID N/A

Gene Information

Gene Name: cplR
Allele: Cper_cplR
Encodes: Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins
Source Database: Card Database
Mechanism: antibiotic target protection
Organisms Tested In: • Clostridium perfringens str. 13
Sequence Accession: BA000016.3
Protein Accession: BAB80490.1
Notes: ARO:3007644

PMID N/A

Gene Information

Gene Name: cplR
Allele: Cspo_cplR
Encodes: Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins
Source Database: Card Database
Mechanism: antibiotic target protection
Organisms Tested In: • Clostridium sporogenes
Sequence Accession: CP009225.1
Protein Accession: AKC61310.1
Notes: ARO:3007645

Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR.

PMID 36951104 · 2023

The study identifies and characterizes three genome-encoded ABCF factors, CplR, VmlR2, and Ard1, which confer intrinsic antibiotic resistance in Gram-positive bacteria. CplR provides resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics, VmlR2 confers resistance to nucleoside and PLS A antibiotics, and Ard1 provides self-resistance to nucleoside antibiotics.

Gene Information

Gene Name: cplR
Allele: CplR
Encodes: ABC transporter
Source Database: Reslit
Mechanism: mediates intrinsic resistance to pleuromutilin, lincosamide and streptogramin A antibiotics
Confers Resistance To: pleuromutilinslincosamidesstreptogramin a
Organisms Tested In: • Clostridium difficile
• Clostridium perfringens
• Clostridium sporogenes
Validation Method: expression in B. subtilis ΔvmlR and MIC testing
Sequence Accession: WP_011861613.1|WP_003234144.1|WP_024026878.1