Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
chloramphenicol phosphotransferase CPT
Overview
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.
Synthesis and evaluation of hetero- and homodimers of ribosome-targeting antibiotics: antimicrobial activity, in vitro inhibition of translation, and drug resistance.
The study describes the synthesis of homo- and hetero-dimers of ribosome-targeting antibiotics (tobramycin, clindamycin, and chloramphenicol) and evaluates their antimicrobial activity, in vitro translation inhibition, and effectiveness against drug-modifying enzymes. The dimers showed improved antimicrobial activity and reduced susceptibility to resistance mechanisms compared to the parent antibiotics.
Molecular Characterization and Antimicrobial Susceptibilities of Nocardia Species Isolated from the Soil; A Comparison with Species Isolated from Humans.
The study identified various antimicrobial resistance genes in Nocardia species isolated from soil, including beta-lactamase, aminoglycoside modifying enzymes, macrolide resistance genes, chloramphenicol resistance proteins, vancomycin resistance, and multidrug efflux pumps. Some soil N. cyriacigeorgica strains exhibited distinct genetic profiles suggesting possible new subspecies or species.
Inactivation of chloramphenicol by O-phosphorylation. A novel resistance mechanism in Streptomyces venezuelae ISP5230, a chloramphenicol producer.
The study identifies a novel chloramphenicol resistance mechanism in Streptomyces venezuelae ISP5230 involving the enzyme chloramphenicol 3'-O-phosphotransferase, which inactivates chloramphenicol through O-phosphorylation.
Inactivation of chloramphenicol by O-phosphorylation. A novel resistance mechanism in Streptomyces venezuelae ISP5230, a chloramphenicol producer.
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