Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
MFS efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| E38A | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| D46A | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| D46N | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| E338A | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| Y42A | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| Y42F | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| Y73A | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| Y73L | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| Y73F | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| N45A | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| L74A | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| I250A | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| F372A | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| R124A | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| R124H | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| E38D | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| D46E | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| E338D | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| E338N | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| E338Q | - | - | - | phenicols|ethidium bromide|norfloxacin|mitomycin c|florfenicol|thiamphenicol|benzalkonium chloride|chlorhexidine | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| craA | Reslit | 9 | phenicols, ethidium bromide +2 | Acinetobacter baumannii +2 | Global|India|Spain, Germany, Spain, France, India, South Korea, China|Korea|Japan | 2011, 2012, 2013, 2021, 2024, 2025 | KF147860|KF147861|KF147862 | - |
| CraA | Reslit | 1 | phenicols | Acinetobacter baumannii | - | 2020 | - | - |
Efflux-mediated antibiotic resistance in Acinetobacter spp.
The study characterizes several efflux pumps in Acinetobacter spp., including AdeABC, AdeIJK, AdeFGH, CraA, AmvA, AbeM, AbeS, AdeXYZ, AdeDE, TetA, TetB, CmlA, FloR, and QacE, which contribute to multidrug resistance by expelling antibiotics and other compounds.
The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.
The paper discusses various virulence factors and mechanisms contributing to the pathogenicity and antibiotic resistance of Acinetobacter baumannii, including biofilm formation, surface polysaccharides, and outer membrane proteins.
Single-step selection of drug resistant Acinetobacter baylyi ADP1 mutants reveals a functional redundancy in the recruitment of multidrug efflux systems.
The study identifies the RND efflux pump adeJ and the MFS efflux pump craA as key contributors to multidrug resistance in Acinetobacter baylyi ADP1. A T to G substitution upstream of the craA translation initiation codon was found to enhance mRNA stability and contribute to resistance.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
Contribution of efflux pumps, porins, and β-lactamases to multidrug resistance in clinical isolates of Acinetobacter baumannii.
The study identifies multiple efflux pumps, porins, and β-lactamases contributing to multidrug resistance in Acinetobacter baumannii, including adeB, adeJ, tetB, tetA(39), and aacC1, aphA1, aadB genes, along with mutations in gyrA and parC.
Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii.
The paper discusses the antibiotic resistance profiles and molecular mechanisms of Acinetobacter baumannii, highlighting the presence of various beta-lactamases such as blaOXA-23, blaOXA-51, blaOXA-24/40, blaOXA-58, blaOXA-143, blaOXA-235, blaIMP, blaVIM, and blaNDM, as well as aminoglycoside-modifying enzymes like aac(6')-Ib, aph(3')-Ia, and ant(2'')-Ia. It also identifies efflux pumps such as adeABC and tetracycline resistance genes like tet(A).
Efflux Pump Overexpression Profiling in Acinetobacter baumannii and Study of New 1-(1-Naphthylmethyl)-Piperazine Analogs as Potential Efflux Inhibitors.
The study identifies the overexpression of efflux pump genes such as adeJ, adeG, adeB, abeM, abaQ, and craA in Acinetobacter baumannii strains, contributing to fluoroquinolone resistance. It also evaluates new 1-(1-naphthylmethyl)-piperazine analogs as potential efflux pump inhibitors.
Genotypic and Phenotypic Characterization of Novel Sequence Types of Carbapenem-Resistant Acinetobacter baumannii, With Heterogeneous Resistance Determinants and Targeted Variations in Efflux Operons.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii strains, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, contributing to multidrug resistance.
Prevalence of antibiotic-resistant Acinetobacter spp. on soil and crops collected from agricultural fields in South Korea.
The study identified several antibiotic resistance genes in Acinetobacter spp. isolated from agricultural fields in South Korea, including emrAB, cat, craA, and aadA, which confer resistance to colistin, chloramphenicol, and streptomycin.
Gut microbiome profiling of a migratory Anser serrirostris population reveals two groups with distinct pathogen and ARG contents.
The study identified two distinct gut microbiome groups (E1 and E2) in a migratory Anser serrirostris population, with E1 showing higher abundances of opportunistic pathogens and antibiotic resistance genes (ARGs). Key ARGs included beta-lactamase-encoding genes such as blaCTX-M, blaZ, blaCARB-1, blaADC, blaPDC, and blaOXA-213, which were more prevalent in E1.
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