croR

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response regulator

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to croR

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: disrupts phosphorylation
Validation Method: RNAseq and disc diffusion assay
Drug Classes: cephalosporins, ceftazidime
Organisms: Enterococcus faecalis
Papers: 3
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
D52A	-	disrupts phosphorylation	Enterococcus faecalis	ceftazidime	Reslit	Candidate
E2G	A7G	altered association with HPr and cephalosporin resistance	Enterococcus faecalis	cephalosporins	Reslit	Candidate

Papers3

Arginine impacts aggregation, biofilm formation, and antibiotic susceptibility in Enterococcus faecalis.

PMID 39524554 · 2024

Arginine metabolism in Enterococcus faecalis leads to increased aggregation, decreased biofilm formation, and altered antibiotic susceptibility, particularly to ampicillin and ceftriaxone.

Gene Information

Gene Name: croR
Allele: croR
Encodes: response regulator
Source Database: Reslit
Confers Resistance To: cephalosporins
Organisms Tested In: • Enterococcus faecalis
Validation Method: RNAseq and disc diffusion assay
Sequence Accession: GSE268264

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croR

Mutations

Gene Information

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croR

Mutations

Gene Information