crxA

CrxA family subclass B1 metallo-beta-lactamase

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: gene transfer to a carbapenem-susceptible host, 5'-RACE, PCR, and MIC testing
Drug Classes: CARBAPENEM, carbapenems
Organisms: Bacteroides sp., Bacteroides xylanisolvens, Bacteroides fragilis
Geographic Location: Hungary
Papers: 1
Databases: Card DatabaseReference Gene CatalogReslit

Papers1

PMID N/A

Gene Information

Gene Name: crxA
Allele: crxA
Encodes: CrxA family subclass B1 metallo-beta-lactamase
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Bacteroides sp.
Sequence Accession: JAGZKL010000021.1
Protein Accession: MBS5055441.1
Notes: ARO:3007118

PMID N/A

Gene Information

Gene Name: crxA
Allele: crxA
Encodes: CrxA family subclass B1 metallo-beta-lactamase, subclass B1 Bacteroides xylanisolvens crx beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Bacteroides sp.
Sequence Accession: JAGZKL010000021.1
Protein Accession: MBS5055441.1
Notes: ARO:3007118

A novel Bacteroides metallo-β-lactamase (MBL) and its gene (crxA) in Bacteroides xylanisolvens revealed by genomic sequencing and functional analysis.

PMID 35296904 · 2022

The study identified a novel metallo-β-lactamase gene, crxA, in Bacteroides xylanisolvens, which confers carbapenem resistance. The gene is part of a genomic island and is activated by an IS 1380-like IS element. crxA was found to be specific to B. xylanisolvens with a prevalence of 16.7% among clinical isolates in Hungary.

Gene Information

Gene Name: crxA
Allele: crxA
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Bacteroides xylanisolvens
• Bacteroides fragilis
Geographic Location: Hungary
Validation Method: gene transfer to a carbapenem-susceptible host, 5'-RACE, PCR, and MIC testing
Sequence Accession: PRJNA481227

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crxA

CrxA family subclass B1 metallo-beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to crxA

AMR Rules

Browse AMR rules for crxA

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: gene transfer to a carbapenem-susceptible host, 5'-RACE, PCR, and MIC testing
Drug Classes: CARBAPENEM, carbapenems
Organisms: Bacteroides sp., Bacteroides xylanisolvens, Bacteroides fragilis
Geographic Location: Hungary
Papers: 1
Databases: Card DatabaseReference Gene CatalogReslit

Papers1

PMID N/A

Gene Information

Gene Name: crxA
Allele: crxA
Encodes: CrxA family subclass B1 metallo-beta-lactamase
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Bacteroides sp.
Sequence Accession: JAGZKL010000021.1
Protein Accession: MBS5055441.1
Notes: ARO:3007118

PMID N/A

Gene Information

Gene Name: crxA
Allele: crxA
Encodes: CrxA family subclass B1 metallo-beta-lactamase, subclass B1 Bacteroides xylanisolvens crx beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Bacteroides sp.
Sequence Accession: JAGZKL010000021.1
Protein Accession: MBS5055441.1
Notes: ARO:3007118

A novel Bacteroides metallo-β-lactamase (MBL) and its gene (crxA) in Bacteroides xylanisolvens revealed by genomic sequencing and functional analysis.

PMID 35296904 · 2022

Gene Information

Gene Name: crxA
Allele: crxA
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Bacteroides xylanisolvens
• Bacteroides fragilis
Geographic Location: Hungary
Validation Method: gene transfer to a carbapenem-susceptible host, 5'-RACE, PCR, and MIC testing
Sequence Accession: PRJNA481227

Comments (0)

No comments yet. Be the first to comment!

crxA

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crxA

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