csbC

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N-succinyltransferase

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to csbC

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: expression in E. coli and testing of antibiotic activity
Drug Classes: kanamycin, ampicillin
Organisms: Escherichia coli, Streptomyces lividans
Geographic Location: China
Papers: 1
Databases: Reslit

Papers1

N-Succinyltransferase Encoded by a Cryptic Siderophore Biosynthesis Gene Cluster in Streptomyces Modifies Structurally Distinct Antibiotics.

PMID 36040031 · 2022

The study identifies CsbC, an N-succinyltransferase from Streptomyces sp. strain YIM 121038, which modifies antibiotics like kanamycin and ampicillin, leading to reduced antibiotic activity. CsbC provides low-level resistance to these antibiotics in vivo.

Gene Information

Gene Name: csbC
Allele: csbC
Encodes: N-succinyltransferase
Source Database: Reslit
Confers Resistance To: kanamycinampicillin
Organisms Tested In: • Escherichia coli
• Streptomyces lividans
Geographic Location: China
Validation Method: expression in E. coli and testing of antibiotic activity
Sequence Accession: NCBI:txid2136401|CP030771.1|CP030772.1|MH429786

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csbC

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csbC

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