cwlM

View on PubMed

Lytic murein transglycosylase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to cwlM

AMR Rules

Browse AMR rules for cwlM

Validation StatusCandidate

Overview

Mechanism: confers resistance to beta-lactams
Validation Method: core-SNV analysis and MIC testing
Drug Classes: amoxicillin, meropenem, amoxicillin|meropenem
Organisms: Mycobacterium tuberculosis
Geographic Location: Portugal
Papers: 1
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
M237V	-	-	Mycobacterium tuberculosis	amoxicillin\|meropenem	Reslit	Candidate

Papers1

Uncovering Beta-Lactam Susceptibility Patterns in Clinical Isolates of Mycobacterium tuberculosis through Whole-Genome Sequencing.

PMID 35695524 · 2022

The study identifies several genes and mutations associated with beta-lactam susceptibility in Mycobacterium tuberculosis, highlighting the role of specific genetic variations in influencing resistance patterns.

Gene Information

Gene Name: cwlM
Allele: cwlM
Encodes: Lytic murein transglycosylase
Source Database: Reslit
Mechanism: confers resistance to beta-lactams
Confers Resistance To: amoxicillinmeropenem
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Portugal
Validation Method: core-SNV analysis and MIC testing
Sequence Accession: NCBI BioProject PRJNA735825

Comments (0)

No comments yet. Be the first to comment!

cwlM

Mutations

Gene Information

Browse AMR Genes

cwlM

Mutations

Gene Information