Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
D-serine, L- and D-alanine, and glycine transporter
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G122S | - | - | Mycobacterium bovis, Mycobacterium tuberculosis, Mycobacterium smegmatis | cycloserine | Reslit | Candidate |
| R93L | - | Mycobacterium tuberculosis | cycloserine | Reslit | Candidate | |
| R477G | - | - | Mycobacterium tuberculosis | cycloserine | Reslit | Candidate |
| - | - | Mycobacterium tuberculosis | cycloserine | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | cycloserine | Reslit | Candidate |
A point mutation in cycA partially contributes to the D-cycloserine resistance trait of Mycobacterium bovis BCG vaccine strains.
A point mutation in the cycA gene of Mycobacterium bovis BCG, resulting in a G122S amino acid substitution, partially contributes to D-cycloserine resistance. The mutation affects the transporter's function, reducing D-cycloserine uptake and contributing to resistance.
Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.
The study identified multiple AMR genes and mutations in Mycobacterium tuberculosis variant bovis strains from Mato Grosso, Brazil, including resistance to pyrazinamide, isoniazid, rifampicin, streptomycin, ethambutol, ethionamide, fluoroquinolones, kanamycin, capreomycin, paraminosalicylic acid, cycloserine, bedaquiline, linezolid, and delamanid.
Global pathogenomic analysis identifies known and candidate genetic antimicrobial resistance determinants in twelve species.
Two candidate AMR genes, cycA and frdD, were experimentally validated in E. coli BW25113, showing conditional resistance to ciprofloxacin and ampicillin, respectively.
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