cyoA

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cytochrome oxidase subunit I

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to cyoA

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Validation StatusCandidate

Overview

Mechanism: mutation-mediated resistance
Validation Method: evolution experiment and MIC assays
Drug Classes: tobramycin
Organisms: Pseudomonas aeruginosa, Acinetobacter baumannii
Papers: 1
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G460V	-	-	Acinetobacter baumannii, Pseudomonas aeruginosa	tobramycin	Reslit	Candidate

Papers1

Parallel Evolution of Tobramycin Resistance across Species and Environments.

PMID 32457248 · 2020

The study identifies mutations in fusA1 and ptsP as key contributors to tobramycin resistance in Acinetobacter baumannii and Pseudomonas aeruginosa, highlighting parallel evolution across species and environments.

Gene Information

Gene Name: cyoA
Allele: cyoA
Encodes: cytochrome oxidase subunit I
Source Database: Reslit
Mechanism: mutation-mediated resistance
Confers Resistance To: tobramycin
Organisms Tested In: • Pseudomonas aeruginosa
• Acinetobacter baumannii
Validation Method: evolution experiment and MIC assays
Sequence Accession: NCBI GenBank: CP042125|NCBI GenBank: CP042126|NZ_CP012004|NZ_CP012005|NC_008463

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cyoA

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cyoA

Mutations

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