cysB

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transcriptional regulator

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Validation StatusCandidate

Overview

Mechanism: inactivation leads to resistance
Validation Method: mutant strains showed resistance in MHB but susceptibility in urine
Drug Classes: mecillinam
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Reversion of High-level Mecillinam Resistance to Susceptibility in Escherichia coli During Growth in Urine.

PMID 28855073 · 2017

The study shows that mecillinam resistance in E. coli cysB mutants can be phenotypically reversed to susceptibility when grown in urine, highlighting the influence of environmental conditions on antibiotic resistance.

Gene Information

Gene Name: cysB
Allele: cysB
Encodes: transcriptional regulator
Source Database: Reslit
Mechanism: inactivation leads to resistance
Confers Resistance To: mecillinam
Organisms Tested In: • Escherichia coli
Validation Method: mutant strains showed resistance in MHB but susceptibility in urine

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cysB

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cysB

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