cysE

View on PubMed

serine acetyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to cysE

AMR Rules

Browse AMR rules for cysE

Validation StatusCandidate

Overview

Mechanism: modulates oxidative stress responses
Validation Method: mutant construction and complementation, susceptibility testing
Drug Classes: clofazimine
Organisms: Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

The acetyltransferase CysE modulates virulence and drug resistance of Mycobacterium tuberculosis by interfering with oxidative stress responses.

PMID 41053365 · 2025

The study identifies cysE as a critical gene for Mycobacterium tuberculosis survival in macrophages and mice, and shows that its disruption increases susceptibility to clofazimine by enhancing oxidative stress.

Gene Information

Gene Name: cysE
Allele: cysE
Encodes: serine acetyltransferase
Source Database: Reslit
Mechanism: modulates oxidative stress responses
Confers Resistance To: clofazimine
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: mutant construction and complementation, susceptibility testing

Comments (0)

No comments yet. Be the first to comment!

cysE

Gene Information

Browse AMR Genes

cysE

Gene Information