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czcS

two-component system sensor kinase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to czcS

Browse AMR rules for czcS

Overview

Mechanism: sensor histidine kinase CzcS
Drug Classes: carbapenems, imipenem, cefiderocol
Organisms: Pseudomonas aeruginosa
Papers: 2
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
V194L	-	sensor histidine kinase CzcS	Pseudomonas aeruginosa	carbapenemsimipenem	ReslitReference Gene Catalog	Candidate
R246S	-	-	Pseudomonas aeruginosa	cefiderocol	Reslit	Candidate

Papers2

1

CzcR-CzcS, a two-component system involved in heavy metal and carbapenem resistance in Pseudomonas aeruginosa.

PMID 14679195 · 2004

The V194L mutation in CzcS leads to constitutive activation of the two-component system, resulting in carbapenem resistance.

czcS

Mutation Information

Protein Change: V194L
Organisms: Pseudomonas aeruginosa
Confers Resistance To: carbapenemsimipenem
Effect on Function: sensor histidine kinase CzcS
Validation Method: sequencing and functional analysis; mutant analysis
Source Database: ReslitReference Gene Catalog

2

In vitro resistance development gives insights into molecular resistance mechanisms against cefiderocol.

PMID 39080477 · 2024

Mutation Information

Protein Change: R246S
Organisms: Pseudomonas aeruginosa
Confers Resistance To: cefiderocol
Validation Method: whole-genome sequencing
Source Database: Reslit