dacA

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diadenylate cyclase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to dacA

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: disrupts the catalytic capability of DacA
Validation Method: whole genome sequencing and markerless allelic replacement
Drug Classes: methicillin, cefuroxime
Organisms: Staphylococcus aureus, Listeria monocytogenes
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
D171A	-	disrupts the catalytic capability of DacA	Listeria monocytogenes	cefuroxime	Reslit	Candidate

Papers2

Mutation in the C-di-AMP cyclase dacA affects fitness and resistance of methicillin resistant Staphylococcus aureus.

PMID 24013956 · 2013

The study identifies a mutation in the diadenylate cyclase gene dacA that reduces c-di-AMP levels, leading to decreased methicillin resistance and increased fitness in Staphylococcus aureus.

Gene Information

Gene Name: dacA
Allele: dacA
Encodes: diadenylate cyclase
Source Database: Reslit
Confers Resistance To: methicillin
Organisms Tested In: • Staphylococcus aureus
Validation Method: whole genome sequencing and markerless allelic replacement
Sequence Accession: PRJEB400|ERS251419|ERS251420|ERS251421|CP000253

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dacA

Mutations

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dacA

Mutations

Gene Information