dagK

diacylglycerol kinase

Overview

Drug Classes: daptomycin, benzalkonium chloride
Organisms: Enterococcus faecium, Listeria monocytogenes
Papers: 2
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
P226A	-	-	Enterococcus faecium	daptomycin	Reslit	Candidate
-	G245A	-	Listeria monocytogenes	benzalkonium chloride	Reslit	Candidate

Papers2

Evolution of vancomycin-resistant Enterococcus faecium during colonization and infection in immunocompromised pediatric patients.

PMID 32393645 · 2020

Mutation Information

dagK: p.P226A

Protein Change: P226A
Organisms: Enterococcus faecium
Confers Resistance To: daptomycin
Validation Method: MIC and MBC determination
Source Database: Reslit

Chemical mutagenesis of Listeria monocytogenes for increased tolerance to benzalkonium chloride shows independent genetic underpinnings and off-target antibiotic resistance.

PMID 39028728 · 2024

Mutation Information

dagK: c.G245A

Nucleotide Change: G245A
Organisms: Listeria monocytogenes
Confers Resistance To: benzalkonium chloride
Validation Method: whole genome sequencing
Source Database: Reslit

dagK

Mutations

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dagK

Mutations

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