dapF

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diaminopimelate epimerase

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to dapF

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Validation StatusCandidate

Overview

Mechanism: inactivation of nonessential gene involved in cell wall biogenesis
Validation Method: comparison of MICs in wild type and mutant harboring plasmid
Drug Classes: cefoxitin
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Cephem Potentiation by Inactivation of Nonessential Genes Involved in Cell Wall Biogenesis of β-Lactamase-Producing Escherichia coli.

PMID 27956425 · 2017

Inactivation of dapF and mrcB genes in β-lactamase-producing E. coli restored susceptibility to cefoxitin and reduced MICs of other cephems, demonstrating their potential as helper drug targets for enhancing cephem activity.

Gene Information

Gene Name: dapF
Allele: dapF
Encodes: diaminopimelate epimerase
Source Database: Reslit
Mechanism: inactivation of nonessential gene involved in cell wall biogenesis
Confers Resistance To: cefoxitin
Organisms Tested In: • Escherichia coli
Validation Method: comparison of MICs in wild type and mutant harboring plasmid

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dapF

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dapF

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