Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
d-Ala:d-Ala ligase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G184S | - | impaired | Enterococcus faecium | vancomycin | Reslit | Candidate |
| T289P | - | - | Enterococcus avium | vancomycin | Reslit | Candidate |
| S183A | - | reduces d-Ala affinity | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| E13G | - | - | - | vancomycin | Reslit | Candidate |
| S319N | - | - | - | vancomycin | Reslit | Candidate |
| F258Y | increases vancomycin sensitivity, reduced vancomycin resistance | Lactobacillus reuteri, Lactobacillus plantarum | vancomycin | Reslit | Candidate | |
| F260Y | - | increases vancomycin sensitivity | Lactobacillus plantarum | vancomycin | Reslit | Candidate |
VanD-Type Vancomycin-Resistant Enterococcus faecium and Enterococcus faecalis.
The study identifies mutations in the ddl gene that impair d-Ala:d-Ala ligase activity, leading to vancomycin resistance in VanD-type Enterococcus faecium and Enterococcus faecalis strains.
High efficiency recombineering in lactic acid bacteria.
The study demonstrates the use of ssDNA recombineering to introduce targeted mutations in Lactobacillus reuteri, reducing its intrinsic vancomycin resistance through a single amino acid change in the d-Ala-d-Ala ligase (Ddl) enzyme.
Complete Genomic Analysis of VRE From a Cattle Feedlot: Focus on 2 Antibiotic Resistance.
The study identified multiple antibiotic resistance genes in vancomycin-resistant enterococci (VRE) isolates from a cattle feedlot, including vanC1, vanC2/C3, vanXY-C, VanR, macA, macB, rlmA (II), erm(A), aac(6')-la, blaEC, tet(A), tet(L), S10p, gyrA, gyrB, msbA, S12p, rpoB, mdfA/cmr, liaF, liaR, liaS, bcrC, mprF, pgsA, ef-G, ef-TU, ddl, alr, kasA, isotRNA, inhA, fabl, murA, folA, and Dfr, which confer resistance to various antibiotics such as vancomycin, macrolides, aminoglycosides, β-lactams, tetracyclines, quinolones, and others.
Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.
The study identified multiple AMR genes and mutations in Mycobacterium tuberculosis variant bovis strains from Mato Grosso, Brazil, including resistance to pyrazinamide, isoniazid, rifampicin, streptomycin, ethambutol, ethionamide, fluoroquinolones, kanamycin, capreomycin, paraminosalicylic acid, cycloserine, bedaquiline, linezolid, and delamanid.
Selection of Multi-Drug Targets against Drug-Resistant Mycobacterium tuberculosis XDR1219 Using the Hyperbolic Mapping of the Protein Interaction Network.
The study identifies several drug targets (DTs) in Mycobacterium tuberculosis XDR1219 using hyperbolic mapping of the protein interaction network. Key DTs include rpsA, rpsL, embB, embA, fbiC, fbiB, rpoB, dnaK, rpoA, rpoC, rpoZ, ddl, alr, pbpB, rplD, rplC, rmlC, Isr2, tlyA, pknB, dprE1, fas, accD1, accE5, Rv0200, galE3, pks5, msl3, phoP, dacB2, pknI, echA19, ltp3, and Rv3520c, which are involved in various metabolic pathways and are targeted by different antibiotics.
Draft genome sequence of novel Candidatus Ornithobacterium hominis carrying antimicrobial resistance genes in Egypt.
The study presents the draft genome sequence of Candidatus Ornithobacterium hominis, highlighting the presence of multiple antimicrobial resistance genes, including those conferring resistance to sulfonamides, aminoglycosides, fluoroquinolones, and others. Key genes identified include oxyR, gidB, murA, rpoB, gyrA, and others, which were experimentally validated for their resistance mechanisms.
AMR mechanisms in L. interrogans serovars: a comprehensive study.
The study identified 32 AMR genes in Leptospira interrogans serovars, with 20 key genes consistently present across most strains. Unique efflux pump systems were found in serovar Pomona, suggesting distinct resistance mechanisms.
Sequence of the vanB and ddl genes encoding D-alanine:D-lactate and D-alanine:D-alanine ligases in vancomycin-resistant Enterococcus faecalis V583.
The vanB and ddl genes were identified as encoding D-alanine:D-lactate and D-alanine:D-alanine ligases, respectively, in vancomycin-resistant Enterococcus faecalis V583. These genes contribute to glycopeptide resistance mechanisms.
Vancomycin-resistant enterococci.
The study characterizes the vanA gene cluster responsible for vancomycin resistance in enterococci, detailing its mechanism of action through the synthesis of D-alanine-D-lactate, which prevents vancomycin from binding to cell wall precursors.
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