ddl2

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d-Ala:d-Ala ligase

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UniProt

Protein entries specific to ddl2

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Validation StatusCandidate

Overview

Validation Method: biochemical characterization by thin-layer chromatography
Drug Classes: vancomycin
Organisms: Enterococcus gallinarum BM4174, Enterococcus faecalis BM4320, Escherichia coli
Papers: 1
Databases: Reslit

Papers1

D-Ala:D-Ala Ligase Gene Flanking the vanC Cluster: Evidence for Presence of Three Ligase Genes in Vancomycin-Resistant Enterococcus gallinarum BM4174.

PMID 11751117 · 2002

The study identifies a second d-Ala:d-Ala ligase gene (ddl2) in vancomycin-resistant Enterococcus gallinarum BM4174, suggesting the presence of three ligase genes, two encoding d-Ala:d-Ala ligases and one encoding a d-Ala:d-Ser ligase.

Gene Information

Gene Name: ddl2
Allele: ddl2
Encodes: d-Ala:d-Ala ligase
Source Database: Reslit
Confers Resistance To: vancomycin
Organisms Tested In: • Enterococcus gallinarum BM4174
• Enterococcus faecalis BM4320
• Escherichia coli
Validation Method: biochemical characterization by thin-layer chromatography
Sequence Accession: AF363615

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ddl2

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ddl2

Gene Information