ddlA

D-alanine:D-alanine ligase

Overview

Mechanism: single resistance variant
Drug Classes: cycloserine
Organisms: Mycobacterium tuberculosis
Papers: 2
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
T365A	A1095G	single resistance variant	Mycobacterium tuberculosis	cycloserine	ReslitCard Database	Candidate

Papers2

Genome Analysis of the First Extensively Drug-Resistant (XDR) Mycobacterium tuberculosis in Malaysia Provides Insights into the Genetic Basis of Its Biology and Drug Resistance.

PMID 26110649 · 2015

associated with D-cycloserine resistance

Mutation Information

ddlA: p.T365A

Protein Change: T365A
Confers Resistance To: cycloserine
Validation Method: genomic analysis; polymorphism analysis
Source Database: Reslit

Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.

PMID 30337678 · 2018

Mycobacterium tuberculosis ddlA mutations confer resistance to cycloserine; CARD accession: CARD:3004941

Mutation Information

ddlA: p.T365A

Protein Change: T365A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: cycloserine
Effect on Function: single resistance variant
Source Database: Card Database

ddlA

Mutations

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ddlA

Mutations

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