dedA

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Putative integral membrane protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

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UniProt

Protein entries specific to dedA

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Validation StatusCandidate

Overview

Mechanism: Confers resistance to colistin by maintaining membrane integrity
Validation Method: Knockout and complementation experiments showing reduced MIC of colistin
Drug Classes: colistin
Organisms: Klebsiella pneumoniae ST258
Geographic Location: Europe
Papers: 1
Databases: Reslit

Papers1

The secondary resistome of multidrug-resistant Klebsiella pneumoniae.

PMID 28198411 · 2017

The study identifies dedA as a non-essential gene that, when inactivated, restores colistin susceptibility in multidrug-resistant Klebsiella pneumoniae ST258.

Gene Information

Gene Name: dedA
Allele: dedA
Encodes: Putative integral membrane protein
Source Database: Reslit
Mechanism: Confers resistance to colistin by maintaining membrane integrity
Confers Resistance To: colistin
Organisms Tested In: • Klebsiella pneumoniae ST258
Geographic Location: Europe
Validation Method: Knockout and complementation experiments showing reduced MIC of colistin
Sequence Accession: LT216436|LT216437|LT216438|LT216439|LT216440|LT216436-LT216440

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dedA

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dedA

Gene Information