desab

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RND-8 efflux pump

NCBI Pathogen Isolates

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UniProt

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Validation StatusCandidate

Overview

Mechanism: mediates resistance to envelope-targeting antimicrobials
Validation Method: mutant analysis, reporter gene assays, and EMSAs
Drug Classes: chlorhexidine
Organisms: D. oryzae EC1, B. cenocepacia H111, B. cenocepacia ATCC 25416
Papers: 1
Databases: Reslit

Papers1

Gram-negative bacteria resist antimicrobial agents by a DzrR-mediated envelope stress response.

PMID 36978084 · 2023

The study identifies DzrR as a key regulator of zeamine resistance in Dickeya oryzae EC1, demonstrating its role in activating the RND efflux pump desAB. DzrR homologs in Ralstonia and Burkholderia species also show similar functionality, indicating a conserved envelope stress response mechanism.

Gene Information

Gene Name: desab
Allele: desAB
Encodes: RND-8 efflux pump
Source Database: Reslit
Mechanism: mediates resistance to envelope-targeting antimicrobials
Confers Resistance To: chlorhexidine
Organisms Tested In: • D. oryzae EC1
• B. cenocepacia H111
• B. cenocepacia ATCC 25416
Validation Method: mutant analysis, reporter gene assays, and EMSAs
Sequence Accession: W909_RS06570

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desab

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desab

Gene Information